Starch-based hemostasis sponge and preparation method of hemostasis sponge

A hemostatic sponge, starch-based technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of high price, low water absorption rate, poor molding performance, etc., to achieve crisp and brittle, good hemostatic effect, molding performance Good results

Active Publication Date: 2015-05-20
北京爱特康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of gelatin hemostatic sponge are: gelatin is derived from pig bone or bovine bone, causing allergic reactions, and there is a risk of mad cow disease, and the water absorption rate is low;
[0004] The disadvantages of collagen hemostatic sponge are: collagen is derived from animal bones, causing allergic reactions, and there is a risk of mad cow disease, and the price is expensive;
[0005] The disadvantages of chitosan hemostatic sponge are: slow absorption and high price;
[0006] The disadvantages of PVF hemostatic sponge are: formaldehyde is toxic and expensive
The common disadvantages of these patents are that the water absorption rate is not high, the molding performance is poor, the strength is low and brittle, and even the starch granules may fall off from the sponge, which seriously affects the application.
[0009] In addition, there are 2 patents on the preparation of starch foam with starch as raw material. Patent CN101003646A discloses a production method of foamable biomaterials and biofoam products. The preparation method is screw extrusion and calendering into pipes or plates. , very low water absorption, not spongy, can not be used as a hemostatic sponge
CN1439033A discloses a kind of starch foam body, and its preparation method is screw extruding, is prepared into film or sheet material, and water absorption rate is very low, is not spongy, can not be used as hemostatic sponge

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0049] The starch-based hemostatic sponge of proportioning as described above, its preparation method comprises the following steps:

[0050] Step 1, starch and hypromellose calcium are cross-linked by a cross-linking agent;

[0051] Step 2, purification treatment;

[0052] In step 3, the finished starch-based hemostatic sponge is prepared after freeze-drying and sterilization.

[0053] The finished product of the starch-based hemostatic sponge can be used in the fields of hemostasis, filling, repair and adhesion prevention of wounds, surgical tissue wounds and defective tissues.

[0054] On the basis of the above technical solution, the specific steps of step 1 are:

[0055] According to the mass volume ratio of starch and pure water is 1:5~20, add starch into pure water, stir well at room temperature to obtain starch suspension,

[0056] Add hypromellose calcium to the starch suspension according to the proportioning ratio, and fully stir at room temperature to obtain a m...

Embodiment 1

[0070] (1) Preparation of hypromellose calcium: In 100g concentration of ethanol solution of 50% (mass percentage), add 15g carboxymethylcellulose and stir well, then add 2g of calcium chloride and stir well, heat to maintain Temperature 50°C, react for 1h, centrifuge to obtain precipitate after reaction, wash with 75% (mass percentage) ethanol, centrifuge twice, then dry at 80°C, and ultrafinely pulverize by ultrafine pulverizer to obtain 2000 mesh hypromellose Su calcium.

[0071] (2) Add 80 g of carboxymethyl starch into 400 ml of pure water, stir fully at room temperature to obtain a starch suspension, then add 10 g of hypromellose calcium, and fully stir at room temperature to obtain a mixture of starch and hypromellose calcium Suspension.

[0072] Add 5 g of sodium trimetaphosphate as a cross-linking agent to the prepared suspension, adjust the pH to 10 with 5% sodium hydroxide solution, and stir fully at 40°C for 2 hours to cross-link the starch and hypromellose calciu...

Embodiment 2

[0076] (1) Preparation of hypromellose calcium: in 100g concentration of ethanol solution of 80% (mass percentage), add 45g carboxymethylcellulose and stir well, then add 4g calcium chloride and stir well, heating maintains Temperature was 80°C, reacted for 5h, centrifuged to obtain precipitate after reaction, washed with 75% (mass percentage) ethanol, centrifuged twice, then dried at 80°C, and ultrafinely pulverized by ultrafine pulverizer to obtain 2000 mesh hypromellose Su calcium.

[0077] (2) Add 95 g of carboxymethyl starch into 1900 ml of pure water, stir well at room temperature to obtain a starch suspension, then add 2 g of hypromellose calcium and stir well at room temperature to obtain a mixed suspension of starch and hypromellose calcium liquid.

[0078] Add 2 g of adipic acid as a cross-linking agent into the prepared suspension, adjust the pH to 10 with 5% sodium hydroxide solution, and fully stir for 3 hours at 60° C. to cross-link the starch and hypromellose c...

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PUM

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Abstract

The invention relates to a medical hemostasis instrument and in particular relates to a starch-based hemostasis sponge and a preparation method of the hemostasis sponge. The starch-based hemostasis sponge is prepared from the following raw materials in parts by weight: 80-95 parts of starch, 2-10 parts of hydroxypropyl methylcellulose calcium, 2-5 parts of a cross-linking agent and 1-5 parts of a plasticizer. The preparation method of the hemostasis sponge comprises the following steps: step one, crosslinking starch with hydroxypropyl methylcellulose calcium by virtue of the cross-linking agent; step two, purifying; and step three, freeze-drying and sterilizing to prepare the finished starch-based hemostasis sponge. According to the starch-based hemostasis sponge and the preparation method of the hemostasis sponge, the hemostasis sponge is prepared by crosslinking starch with hydroxypropyl methylcellulose calcium; the hydroxypropyl methylcellulose calcium is high in water absorption rate, excellent in formability, high in strength and not liable to break, and has a plurality of functions of stopping bleeding, packing and repairing.

Description

technical field [0001] The invention relates to a medical hemostatic appliance, in particular to a starch-based hemostatic sponge and a preparation method thereof. Background technique [0002] Hemostatic sponge plays an important role in the hemostasis, filling and repair of wounds, surgical tissue wounds and defective tissues. There are mainly four kinds of hemostatic sponges that are commercialized now: gelatin hemostatic sponge, collagen hemostatic sponge, chitosan hemostatic sponge, and PVF hemostatic sponge. [0003] The disadvantages of gelatin hemostatic sponge are: gelatin is derived from pig bone or bovine bone, which can cause allergic reactions, there is also the risk of mad cow disease, and the water absorption rate is low; [0004] The disadvantages of collagen hemostatic sponge are: collagen is derived from animal bones, causing allergic reactions, and there is a risk of mad cow disease, and the price is expensive; [0005] The disadvantages of chitosan hemo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44C08J9/28C08J3/24
Inventor 王美岭郝卫国程乐松邬涛
Owner 北京爱特康医疗科技有限公司
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