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Submucous injection material composed of physical cross-linked hydrogel and application thereof

A physical cross-linking and hydrogel technology, which is applied in the field of polymer materials and medical devices, can solve problems such as insufficient bulge height and maintenance time, high price, and application limitations, so as to reduce the difficulty of surgical operations, reduce perforation, and improve safety. sexual effect

Inactive Publication Date: 2015-06-10
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is expensive, requires special storage conditions, and clinical practice shows that sodium hyaluronate may promote the growth of tumor cells, so its application is limited.
[0008] The above-mentioned submucosal injections have common shortcomings in the implementation of ESD surgery: they are always fluid liquids, diffuse rapidly after injection into the submucosal layer, and their bulge height and maintenance time are relatively insufficient

Method used

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  • Submucous injection material composed of physical cross-linked hydrogel and application thereof
  • Submucous injection material composed of physical cross-linked hydrogel and application thereof
  • Submucous injection material composed of physical cross-linked hydrogel and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0061] Add 30g of PEG (1500°C) into a 250mL three-neck flask, heat the oil bath to 130°C, and vacuumize for 3h while stirring to remove the residual moisture in the PEG. Then, 56g DL-lactide (LA), 8.9g glycolide (GA) and 0.1wt% stannous octoate (containing a small amount of toluene) were added, and the toluene was removed by vacuuming below 100°C for 30min. Raise the temperature to 150°C, and react for 12 hours under an argon atmosphere after the monomers are completely melted. After the reaction, vacuum filter for 3 hours to remove unreacted monomers and low-boiling products, pour out the reaction product while it is hot, wash with water several times and then freeze-dry to obtain a tri-block copolymer with a yield of about 80%. The number-average and weight-average molecular weight (M n ,M w ) were 6690 and 8300, respectively, and the molecular weight distribution coefficient (M w / M n ) is 1.24. Its water system has the characteristic of heat-induced gelation.

Embodiment 2

[0063] Add 22.5 g of monomethoxy-terminated polyethylene glycol (MPEG750) into a 250 mL three-neck flask, heat the oil bath to 130 ° C, and vacuumize for 3 h while stirring to remove residual moisture in MPEG. Add 45g DL-LA, 6g GA and 0.1wt% stannous octoate (containing a small amount of toluene), and vacuum below 100°C for 30min to remove the toluene. Raise the temperature to 150°C, and react for 12 hours under an argon atmosphere after the monomers are completely melted. After the reaction, vacuum filter for 3 hours to remove unreacted monomers and low-boiling products, pour out the reaction product while it is hot, wash with water several times and then freeze-dry to obtain a diblock copolymer material with a yield of about 75%. The number average and weight average molecular weight (MPEG-PLGA, Copolymer-4) of the BA diblock copolymer (MPEG-PLGA, Copolymer-4) were measured by GPC n ,M w ) were 3570 and 4640, respectively, and the molecular weight distribution coefficient ...

Embodiment 3

[0065] Take 15.0g of PEG (1500) in a 250mL three-neck flask, and vacuumize it for 3h while stirring at 130°C to remove the water contained therein. Add 29.0 g of caprolactone (CL) and 0.3 wt % stannous octoate, and react at 120 ° C for 24 h under an argon atmosphere. After the reaction, vacuum filter for 3 hours to remove unreacted monomers and low-boiling products, and then dissolve the initial product in dichloromethane solution, and diethyl ether precipitates. The yield is about 85%. Measure the number average and weight average molecular weight (M) of the BAB block copolymer (PCL-PEG-PCL, Copolymer-8) by GPC n ,M w ) were 7100 and 9230, respectively, and the molecular weight distribution coefficient (M w / M n ) is 1.30. The copolymer itself has the property of thermally reversible gelation in water.

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Abstract

The invention belongs to the fields of high polymer materials and medical equipment and relates to a submucous injection material composed of physical cross-linked hydrogel and an application thereof to preparing injection materials for endoscopic submucosal dissection. The submucous injection material consists of an amphiphilic block copolymer, a solvent which takes water as a main body, and a coloring indicator, wherein the amphiphilic block copolymer is formed by taking polyethylene glycol (PEG) as a hydrophilic block and taking degradable polyester as a hydrophobic block. The material has thermal induced gel-forming properties; when the temperature is lower than a sol-gel transition temperature, a water system presents low-viscosity solution, has good injectable property, and can be subjected to endoscopic injection to the submucosal position so as to spontaneously form in-situ physical hydrogel under the body temperature, good gel morphology is maintained during an ESD operation, the uplift height and duration of the submucous injection material are superior to those of an existing pure liquid material, and the ESD operation is smoothly performed.

Description

technical field [0001] The invention belongs to the field of polymer materials and medical devices, and relates to a submucosal injection material composed of physically cross-linked hydrogel and its application. The submucosal injection material composed of physically cross-linked hydrogel can be used to prepare Submucosal injection materials of the digestive tract, especially in the preparation of injection materials for endoscopic submucosal dissection. Background technique [0002] Endoscopic submucosal dissection (ESD) is a rapidly developed endoscopic treatment technique in recent years. It is mainly used in the resection of early digestive tract cancer, precancerous lesions and submucosal tumors. Its indications include esophageal lesions, gastric lesions, and large intestine lesions. It has the advantages of minimally invasive treatment, avoiding residual lesions, and obtaining complete pathological specimens. The implementation process of ESD includes five stages: ...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/16A61L31/14C08J3/075
Inventor 丁建东俞麟刘岩沈文佳陈昌
Owner FUDAN UNIV
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