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Method for recovering acetylisovaleryltylosin tartrate from acetylisovaleryltylosin tartrate crystallization mother liquor

A technology of acetylisovaleryl tylosine tartrate and acetylisovaleryl tartrate, which is applied in the field of medicine and chemical industry, and can solve the problem that acetylisovaleryl tylosin tartrate is not heat and acid resistant, and the content of tylosin is low. , difficulties in mother liquor recovery, etc., to achieve the effect of reducing the content of pollutants, increasing the available resources, and improving the recovery rate of finished products

Active Publication Date: 2015-06-10
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the traditional process, because the content of acetylisovaleryl tylosin tartrate in the crystallization mother liquor is too low, and acetylisovaleryl tylosin tartrate itself is not heat-resistant and acid-resistant, it cannot be recovered by evaporation and concentration, resulting in relatively difficult recovery of mother liquor. Difficult, therefore, for a long time, the acetylisovaleryl tylosin tartrate crystallization mother liquor has been discharged directly, this method not only causes environmental pollution, but also has a large production loss

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 30 tons of acetylisovaleryl tylosin tartrate production, a single batch of crystallization mother liquor 55m 3 , as detected by HPLC method, the crystallization mother liquor contains 126㎎ / L acetylisovaleryl tylosin, and a large amount of impurities such as pigment, sodium ion, citrate ion, etc.

[0018] Into the mother liquor according to 8g / m 3 Add the alkylbenzene sulfonate at a certain ratio, stir at 20°C for 20 minutes, enter the air bubbler for foaming, and pump the bubble liquid film into the separation tank through the negative pressure siphon. Cool down to 5°C in the separation tank and the liquid film will break naturally, according to 200g / m 3 The proportion of polyferric sulfate (PFS) is added, and at the same time according to 13g / m 3 The proportion of polyacrylamide was added, stirred for 20 minutes, and centrifugally filtered with a centrifuge to obtain a concentrated solution of 600L. According to HPLC detection, the concentrated solution contains 110...

Embodiment 2

[0020] Production of 30 tons of acetylisovaleryl tylosin tartrate, 46m of secondary crystallization mother liquor produced in a single batch 3 , as detected by HPLC method, the crystallization mother liquor contains 52 ㎎ / L acetylisovaleryl tylosin, as well as impurities such as sodium ions and tartrate ions.

[0021] Into the mother liquor according to 10g / m 3 Add α-olefin sulfonate in the ratio of 20°C and stir for 20 minutes, enter the air bubbler for foaming, and pump the bubble liquid film into the separation tank through the negative pressure siphon. Cool down to 10°C in the separation tank and the liquid film will break naturally, according to 200g / m 3 Add a 1:3 mixture of polyalumina and polyferric sulfate (PAC:PFS=1:3) at a ratio of 12g / m 3 The proportion of polyacrylamide was added, stirred for 20 minutes, and centrifugally filtered with a centrifuge to obtain a concentrated solution of 260L. According to HPLC detection, the concentrated solution contains 9096 mg / L...

Embodiment 3

[0023] Production of 600kg grade acetylisovaleryl tylosin tartrate, 9.2m of secondary crystallization mother liquor produced in a single batch 3 According to HPLC detection, the crystallization mother liquor contains 66㎎ / L acetylisovaleryl tylosin, and impurities such as sodium ions, tartrate ions, citrate ions, etc.

[0024] Into the mother liquor according to 9g / m 3 Add α-olefin sulfonate surfactant in the ratio of 22°C and stir for 20 minutes. The mixed solution enters the air foamer for foaming, and the bubble liquid film is pumped into the separation tank through the negative pressure siphon. Cool down to 10-15°C in the separation tank and the liquid film will break naturally, at a rate of 200g / m 3 Add the 3:1 mixture of ferric chloride and aluminum sulfate (ferric chloride: aluminum sulfate = 3:1), and at the same time, according to 15g / m 3 The proportion of polyacrylamide was added, stirred for 20 minutes, and centrifugally filtered with a centrifuge to obtain 60L of ...

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Abstract

The invention relates to a method for recovering acetylisovaleryltylosin tartrate from an acetylisovaleryltylosin tartrate crystallization mother liquor. The method comprises the following steps: firstly, adding a surfactant into the acetylisovaleryltylosin tartrate crystallization mother liquor, then concentrating a thin film by generating air bubbles, collecting air bubble films, cooling the collected air bubble films, adding a separating agent, separating, filtering, crystallizing the obtained filtrate, and washing with water to obtain pure acetylisovaleryltylosin tartrate. The acetylisovaleryltylosin tartrate is recovered by adopting a simple method, so that the problems that the acetylisovaleryltylosin tartrate crystallization mother liquor is too low in unit content of acetylisovaleryltylosin tartrate and acetylisovaleryltylosin tartrate is poor in thermal stability and can not be recovered can be solved, the recycling of acetylisovaleryltylosin tartrate can be realized, the available resources can be increased, the cost can be lowered, the recovery rate of the finished product can be enhanced, the content of pollutants in discharged wastewater can be reduced, the pollution to environment can be alleviated, and certain social and economical benefits can be achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and specifically relates to a method for recovering acetylisovaleryl tylosin tartrate from acetylisovaleryl tylosin tartrate crystallization mother liquor. Background technique [0002] Aivlosin Tartrate (Aivlosin Tartrate, AIV for short) is a new generation of macrolide antibiotics. Common English name: Acetylisovalery tylosin. AIV is a kind of macrolide antibiotics specially used for livestock and poultry which is semi-synthesized on the basis of tylosin through biological fermentation. AIV has resistance activity to many gram-positive bacteria and some negative bacteria, including mycoplasma, vibrio, spirochete and large virus, and has unique curative effect on mycoplasma gallisepticum, porcine epidemic pneumonia and swine dysentery. In the traditional process, because the content of acetylisovaleryl tylosin tartrate in the crystallization mother liquor is too low, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 王义李晓楠高乾赵伯龙
Owner 宁夏泰瑞制药股份有限公司
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