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Medicines used to treat irritable bowel syndrome

A technology for irritable bowel syndrome and enteric-coated preparations, which is applied in drug combinations, antipyretics, and pharmaceutical formulations, and can solve problems such as unsuitability for large-scale industrial production and unstable crude extract components

Active Publication Date: 2018-05-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inulin extract obtained by this technology does not involve whether it has the activity of treating IBS. In addition, what this technology provides is an extraction method for preparing an inulin extract containing inulin and isoinulin, which belongs to crude Extract; and the composition of the crude extract obtained by the preparation method is unstable, and is not suitable for large-scale industrial production

Method used

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  • Medicines used to treat irritable bowel syndrome
  • Medicines used to treat irritable bowel syndrome
  • Medicines used to treat irritable bowel syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment prepares a kind of medicine for the treatment of irritable bowel syndrome, and the active ingredient of the medicine is total lactones of inulin (content>70%), wherein inulin and iso-inulin account for more than 90% of total lactones .

[0036] The above active ingredients of the medicine are prepared into oral preparations; the oral preparations are enteric-coated tablets, enteric-coated capsules or enteric-coated pellets.

[0037] Above-mentioned medicine preparation method comprises the following steps:

[0038] 1) firstly dry the dried roots of Inula chinense, crush them into coarse powder and soak them in ethanol solution;

[0039] 2) Heating the soaked medicinal material to reflux and recovering the solvent to obtain the inulin extract;

[0040] 3) Carry out silica gel column chromatography and collect the eluate from the inulin extract;

[0041] 4) collecting the solvent in the silica gel column chromatography, and drying the solute under reduced...

Embodiment 2

[0065] In this example, the same method as in Example 1 was used to prepare different contents of the medicine for treating irritable bowel syndrome, and its therapeutic effect on rats with constipation-type irritable bowel syndrome was detected, as follows:

[0066] Test animals: male Wistar rats, weighing 120-150 g.

[0067] Test drug:

[0068] Test group 1: 1.8mg / mL pinaverium bromide suspension (positive drug)

[0069] Test group 2: 1mg / mL inulin total lactone emulsion (low dose inulin)

[0070] Test group 3: 3 mg / mL inulin total lactone emulsion (medium dose inulin)

[0071] Test group 4: 9 mg / mL inulin total lactone emulsion (high dose inulin)

[0072] Test equipment: electronic analytical balance; electronic weighing scale; in-cut high-speed homogenizer; ultraviolet-visible spectrophotometer; sinks; ultrasonic cleaners.

[0073] Test method: Rats were randomly divided into groups, and the rats in each group were raised separately in separate cages. In order to elim...

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Abstract

The invention discloses a medicine for treating irritable bowel syndrome in the field of traditional Chinese medicines. The content of elecampane total lactone is more than 70 percent, and the content of alantolactone and isoalantolactone accounts for over 90 percent of the total lactone. The used elecampane total lactone has the characteristics of well improving gastrointestinal motility and relieving pain and is exact in curative effect on gastrointestinal functional disorder. According to pharmacological testing and screening, the elecampane total lactone is determined to have good curative effects on diarrhea-type and constipation-type irritable bowel syndrome (IBS), and the IBS symptoms can be obviously relieved.

Description

technical field [0001] The invention relates to a technique in the field of traditional Chinese medicine, in particular to a medicine for treating irritable bowel syndrome (IBS). Background technique [0002] Irritable bowel syndrome is a common digestive system disease. It is a bowel dysfunction syndrome characterized by abdominal pain or discomfort, accompanied by changes in defecation characteristics and habits. There is no basis for abnormal morphological and biochemical markers. IBS is a common disease. Epidemiological surveys show that 10% to 20% of healthy people have suffered from this disease, and IBS patients account for more than 50% of the number of gastroenterology outpatients. It is estimated that the vast majority of people will suffer from IBS in their lifetime. This disease is the second common disease that seriously affects people's work and quality of life after the common cold. Once called "allergic colitis", "irritable colitis" or "mucous colitis", the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/285A61P1/00A61P29/00A61P1/12A61P1/10A61K31/365
Inventor 李晓波王梦月彭颖王思齐
Owner SHANGHAI JIAO TONG UNIV
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