A new type of artificial blood vessel
An artificial blood vessel, small-diameter technology, applied in anti-coagulation treatment, packaging item types, special packaging items, etc., can solve the problems of insufficient autologous blood vessel source, intimal hyperplasia, secondary injury of patients, etc., to promote endothelial cell proliferation. , the effect of rapid endothelialization and short production time
Active Publication Date: 2017-03-29
HUNAN UNIV
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Problems solved by technology
Some severely blocked or occluded blood vessels require more and more substitutes. Currently, the commonly used vascular substitutes are autologous blood vessels. However, due to insufficient sources of autologous blood vessels and secondary damage to patients, it is difficult to meet clinical needs. Therefore, Artificially synthesized tissue-engineered blood vessels have received more and more attention, although large-diameter blood vessels with an inner diameter of 6 mm or more can already be used in clinical practice.
However, small-caliber (<6mm) blood vessels are still difficult to apply clinically due to the problems of thrombus, intimal hyperplasia, and difficulty in unblocking them for a long time.
Method used
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[0019] Below in conjunction with embodiment the present invention will be further described.
[0020] Such as figure 1 As shown, the progressively degradable tissue engineered blood vessel of the present invention includes a body 1, an outer layer formed by mixing the inner layer 1 of the body, the middle layer 2, 3 and 4.
[0021] Preparation method of the inner layer: Dissolve polycaprolactone and gelatin in trifluoroethanol at 10% (w / v) respectively, mix 1:1 (v / v) after the dissolution is complete, and then add 2% glacial acetic acid to restore the solution clarify. By electrospinning technology, using a specially made receiving device, such as figure 2 As shown, 5 is a thin iron wire, and 6 is a self-made small disc. Connect the whole receiving device to negative high voltage, so that the spun fibers falling in the middle of the iron wires will be electrostatically drawn due to the same negative high voltage of the iron wires, thereby producing ordered fibers.
[0022...
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Abstract
The present invention discloses an artificial blood vessel belonging to the medical device field. Aiming at the shortcomings in the prior art, the present invention provides a three-layer electrostatic spinning artificial blood vessel capable of being gradually degraded, inner layer ordered electrostatic spinning fiber can be prepared by electrostatic spinning, middle-layer spinning fiber is combined with heparin and vascular endothelial growth factor, thrombosis can be inhibited through the two ways, the sharp proliferation of vascular smooth muscle cells can be inhibited, the growth of blood endothelial cells can be promoted, and rapid endothelialization can be realized, gradual outer layer degradation can be realized, the porosity can be gradually improved, after realizing of the endothelialization, the demand of the growth of the vascular smooth muscle cells can be met, the growth of fibroblast and other cells and formation of collagen and other substances are facilitated.
Description
technical field [0001] In particular, it relates to a gradually degradable multi-layer small-diameter artificial blood vessel. [0002] technical background [0003] With the improvement of the quality of life, cardiovascular diseases such as arterial blockage and sclerosis have seriously threatened human health. Some severely blocked or occluded blood vessels require more and more substitutes. Currently, the commonly used vascular substitutes are autologous blood vessels. However, due to insufficient sources of autologous blood vessels and secondary damage to patients, it is difficult to meet clinical needs. Therefore, Artificially synthesized tissue-engineered blood vessels have received more and more attention, although large-caliber blood vessels with an inner diameter of 6 mm or more can already be used clinically. However, small-caliber (<6mm) blood vessels are still difficult to be used clinically because of the problems of thrombus, intimal hyperplasia, and diffic...
Claims
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IPC IPC(8): A61L27/40A61L27/50A61L27/54A61L33/10
Inventor 谭志凯王洪杰高祥凯谭拥军
Owner HUNAN UNIV