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Preparation method and application of cholesterol-carboxymethyl chitosan derivative meterials

A technology of carboxymethyl chitosan and cholesterol, which is applied in the field of preparation of cholesterol-carboxymethyl chitosan derivative materials, can solve the problems of no induced release function, low compatibility, non-natural degradation, etc. Good slow release controllability, reduce environmental pollution, and expand the effect of compatibility

Inactive Publication Date: 2015-08-19
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problems in the prior art that the synthesis price is high, it cannot be naturally degraded, it does not have the function of inducing release, it does not have targeting and sustained release, and its compatibility is not large, the present invention proposes a cholesterol-carboxymethyl shell The preparation method and application of polysaccharide derivative materials, using the cholesterol-carboxymethyl chitosan derivative material of the present invention as a new type of biomass polymer, combined with the physical and chemical properties of high-efficiency pesticides, can develop high-efficiency, low-residue The green environmental protection nanocapsule slow-release antibacterial pesticide new dosage form, which is of great significance for prolonging the duration of pesticide action, reducing the amount of agricultural pesticide application, efficient utilization of pesticides and environmental protection

Method used

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  • Preparation method and application of cholesterol-carboxymethyl chitosan derivative meterials
  • Preparation method and application of cholesterol-carboxymethyl chitosan derivative meterials
  • Preparation method and application of cholesterol-carboxymethyl chitosan derivative meterials

Examples

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Embodiment 1

[0041] (1) Soak 1g of chitosan in isopropanol, add 50wt% NaOH solution in 3 times, and finish adding in 10 minutes, stir at 55°C for 50min to form a pH=12 alkaline environment, and then divide it into 3 times Add 6g of chloroacetic acid once, and add it within 10, and chitosan C 6 For the -OH reaction on the surface, keep the temperature change within the range of 5°C, react for 2.5h, and reflux the ethanol with a volume concentration of 95%, and carry out the hydrazinolysis reaction with a hydrazine hydrate solution with a mass percentage concentration of 85wt%, so that the phthal The imido group is deprotected to form O-carboxymethyl chitosan;

[0042](2) O-carboxymethyl chitosan 0.6g is dissolved in the acetic acid solution that volume ratio is 2%, 0.6g cholesterol is dissolved in the dimethyl formamide, activator carbodiimide 0.3g joins in In the dimethylformamide solution, stir for 25min and slowly drop the mixed solution into the O-carboxymethyl chitosan acetic acid sol...

Embodiment 2

[0045] (1) Soak 1g of chitosan in isopropanol, add 50wt% NaOH solution in 5 times, and finish adding in 15 minutes, stir at 60°C for 55min to form a pH=13 alkaline environment, and then divide into 3 Add 4.5g of chloroacetic acid once, and add it within 15, and chitosan C 6 For the -OH reaction on the surface, keep the temperature change within 5°C, react for 3h, reflux through ethanol with a volume concentration of 95%, and use 85wt% hydrazine hydrate solution for hydrazinolysis reaction to remove the phthalimide group Protection, forming O-carboxymethyl chitosan;

[0046] (2) Dissolving 0.6g of O-carboxymethyl chitosan in 3% acetic acid solution by volume, dissolving 0.6g of cholesterol in dimethylformamide, and dissolving activator N-hydroxysuccinimide 0.24 g was added to the dimethylformamide solution, stirred for 30 minutes and slowly added dropwise the mixed solution to the O-carboxymethyl chitosan solution under magnetic stirring, reacted at room temperature for 2.5 da...

Embodiment 3

[0048] (1) Soak 1g of chitosan in isopropanol, add 50wt% NaOH solution in 4 times, and finish adding in 20 minutes, stir at 65°C for 50min to form a pH=14 alkaline environment, and then divide into 3 Add 12g of chloroacetic acid once, and add it within 20, and chitosan C 6 For the -OH reaction on the surface, keep the temperature change within 5°C, react for 3h, reflux through ethanol with a volume concentration of 95%, and use 85wt% hydrazine hydrate solution for hydrazinolysis reaction to remove the phthalimide group Protection, forming O-carboxymethyl chitosan;

[0049] (2) O-carboxymethyl chitosan 0.6g is dissolved in the acetic acid solution that volume ratio is 4%, and 0.6g cholesterol is dissolved in the dimethylformamide, and activator carbodiimide 0.1g, N Under the action of 0.1g of hydroxysuccinimide, add it to the dimethylformamide solution, stir for 35min and slowly add the mixed solution dropwise to the O-carboxymethyl chitosan acetate solution under magnetic sti...

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Abstract

The present inventio, relating to the field of biomatrix materials, discloses a preparation method and an application of cholesterol-carboxymethyl chitosan derivative materials, to solve the problems in the prior art of high synthesis price, natural degradation incapability, shortage of induction release function, shortage of targeting and slow release properties and poor compatibility. The preparation method comprises: (1) conducting carboxymethylation reaction on collagen on the condition that phthalic anhydride protects -NH2 of collagen C2 to synthesize O-carboxymethyl chitosan; (2) synthesizing cholesterol-carboxymethyl chitosan derivative materials through the esterification reaction of cholesterol and -COOH on carboxymethyl chitosan C6. The cholesterol-carboxymethyl chitosan derivative materials can be used to develop high efficiency and low residue green and environment-friendly nanocapsule slow release antimicrobial pesticide new dosage forms, and can prolong the validity period of the pesticide action, reduce the application amount of pestisides, and achieve high-efficiency pestiside utilization and environment protection.

Description

technical field [0001] The invention relates to the field of biological matrix materials, in particular to a preparation method and application of a cholesterol-carboxymethyl chitosan derivative material. Background technique [0002] Pesticide sustained-release preparations can control the slow release of the original drug for a long time, so as to achieve the purpose of improving the utilization rate of pesticides and reducing environmental pollution. It is the most economical and safest preparation, and belongs to the rapidly developing emerging field in the pesticide preparation market. . Pesticide slow-release agents have potential application value in agricultural and forestry pest control and environmental protection. It has many advantages: (1) improve the physical properties of the drug and improve the stability of the pesticide; (2) effectively reduce environmental factors such as light (3) Reduce the toxicity of pesticides; (4) Extend the duration of pesticide ef...

Claims

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Application Information

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IPC IPC(8): C08B37/08A01N25/18A01N25/28
Inventor 郭明娄钧翼姚珊珊马燕飞
Owner ZHEJIANG FORESTRY UNIVERSITY
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