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Aliphatic polyester-cyclodextrin poly (pseudo) rotaxane and preparation method thereof

An aliphatic polyester, quasi-polyrotaxane technology, applied in the field of new polymer material preparation, can solve the problems of poor gene compatibility and difficult to meet the requirements of biological tissue regeneration, shorten the absorption period, improve hydrophilicity and biological Compatible, high-yield effects

Active Publication Date: 2015-08-26
TIANJIN DEAOSAIEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these materials have high crystallinity, and the polymer molecular chain has a certain degree of hydrophobicity, which is poorly compatible with cells, protein drugs, and genes.
Due to the constraints of the structural properties of aliphatic polyester monomer units, it is still difficult to meet the requirements of biological tissue regeneration by adopting traditional countermeasures such as blending or copolymerization modification, surface modification, and material compounding.

Method used

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  • Aliphatic polyester-cyclodextrin poly (pseudo) rotaxane and preparation method thereof

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Embodiment 1

[0026] An aliphatic polyester-cyclodextane precision polyrotaxane, a supramolecular modified polymer formed by polymerizing the main molecule cyclodextrin and biodegradable aliphatic polyester, the main molecule cyclodextrin is α-cyclodextrin Essence, described biodegradable aliphatic polyester is polydioxanone (PPDO), and its preparation method step is as follows:

[0027] 1) Dissolve 0.60g of polydioxanone (PPDO) in 20mL of N,N-dimethylformamide (DMF), stir magnetically at 60°C until completely dissolved, and obtain solution a;

[0028] 2) Dissolve 1.80g of α-cyclodextrin (α-CD) in 30mL of N,N-dimethylformamide (DMF), stir magnetically at 60°C until completely dissolved, and obtain solution b;

[0029] 3) Add solution b dropwise to solution a, react the resulting mixture at 60°C with magnetic stirring for 20 hours, then cool to room temperature, and continue to react for 5 hours. Repeat this high and low temperature reaction process 3 times to obtain fat Polyester-cyclodext...

Embodiment 2

[0034] An aliphatic polyester-cyclodextane precision polyrotaxane, a supramolecular modified polymer formed by polymerizing the main molecule cyclodextrin and biodegradable aliphatic polyester, the main molecule cyclodextrin is α-cyclodextrin Essence, described biodegradable aliphatic polyester is polycaprolactone (PCL), and its preparation method step is as follows:

[0035] 1) Dissolve 0.20g of polycaprolactone (PCL) in 20mL of acetone, and magnetically stir at 50°C until completely dissolved to obtain solution a;

[0036] 2) Dissolve 1.5 g of α-CD in 15 mL of deionized water at 60°C, and magnetically stir at 60°C until completely dissolved to obtain solution b;

[0037] 3) Add solution b dropwise to solution a, react the obtained mixed solution at 60°C under magnetic stirring for 6 hours, then cool to room temperature, continue to react for 10 hours, repeat this high and low temperature reaction process twice to obtain fat Polyester-cyclodextane precision polyrotaxane solu...

Embodiment 3

[0041] An aliphatic polyester-cyclodextane precision polyrotaxane, a supramolecular modified polymer formed by polymerizing the main molecule cyclodextrin and biodegradable aliphatic polyester, the main molecule cyclodextrin is α-cyclodextrin Essence, described biodegradable aliphatic polyester is L-lactide (PLLA, and its preparation method step is as follows:

[0042] 1) Dissolve 0.25g of poly-L-lactide (PLLA) in 50mL of chloroform, and magnetically stir at 40°C until completely dissolved to obtain solution a;

[0043] 2) Dissolve 1.75 g of α-CD in 10 mL of dimethyl sulfoxide (DMSO), stir magnetically at 60°C until completely dissolved, and obtain solution b;

[0044] 3) Add solution b dropwise to solution a, react the obtained mixed solution at 60°C under magnetic stirring for 6 hours, then cool to room temperature, continue to react for 10 hours, repeat this high and low temperature reaction process twice to obtain fat Polyester-cyclodextane precision polyrotaxane solution...

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Abstract

The invention relates to a method for preparing an aliphatic polyester-cyclodextrin poly (pseudo) rotaxane. The method comprises the following steps: dropwise adding a cyclodextrin solution into a biodegradable aliphatic polyester solution, magnetically stirring for 6-20 h at the temperature of 30-80 DEG C, then cooling to the room temperature and continuous reacting for 5-10 h; repeating the process for 2-4 times, so as to obtain an aliphatic polyester-cyclodextrin poly (pseudo) rotaxane solution; adding a solvent for precipitating the solution, drying separated precipitates for 12-24 h in a drying oven, then respectively washing with the solvent and deionized water, and drying for 12-24 h in the drying oven, so as to obtain the cyclodextrin-aliphatic polyester poly (pseudo) rotaxane. The method has the advantages that the preparation process is simple; the prepared cyclodextrin-aliphatic polyester poly (pseudo) rotaxane is good in biocompatibility and good in hydrophilia and has no toxicity; the poly (pseudo) rotaxane prepared by macromolecular assembly of cyclodextrin and aliphatic polyester has a wide application prospect in the fields of drug release, protein isolation and purification and the like.

Description

technical field [0001] The invention relates to a novel polymer material preparation technology, in particular to an aliphatic polyester-cyclodextrose precision polyrotaxane and a preparation method thereof. Background technique [0002] Cyclodextrins (Cyclodextrins, CD) are D-glucose oligomeric rings linked by α-(1,4)-glycosidic bonds. Common α, β and γ cyclodextrins contain 6, 7, and 8 glucose, respectively. unit. Cyclodextrin has a hydrophilic periphery (strong polarity) and a hydrophobic cavity (weak polarity), and can be assembled with various guest molecules through van der Waals forces and hydrogen bonds to form a host-guest inclusion complex supramolecular system. The host-guest inclusion compound formed by cyclodextrin and polymer can make the polymer have some special characteristics, such as suitable crystallinity, better thermal stability, better water solubility and biodegradability. Because the inclusion effect of cyclodextrin can significantly improve the ph...

Claims

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Application Information

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IPC IPC(8): C08B37/16C08G63/91
Inventor 郭敏杰刘兴之郭维礼
Owner TIANJIN DEAOSAIEN BIOTECH CO LTD
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