Graphene oxide doped molecular imprinted polymer stirring rod as well as preparation method and application thereof

A technology of molecular imprinting and graphene, which is applied in chemical instruments and methods, and other chemical processes, can solve the problems of small adsorption capacity and poor water phase recognition ability of molecular imprinted polymer coatings, and achieve high adsorption capacity and improved water quality. Phase recognition ability, effect of improving adsorption capacity

Inactive Publication Date: 2015-09-02
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention successfully introduces the molecularly imprinted polymer into the stirring rod adsorption extraction technology, and solves the problems of poor water phase recognition ability and small adsorption capacity of the molecularly imprinted polymer coating

Method used

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  • Graphene oxide doped molecular imprinted polymer stirring rod as well as preparation method and application thereof
  • Graphene oxide doped molecular imprinted polymer stirring rod as well as preparation method and application thereof
  • Graphene oxide doped molecular imprinted polymer stirring rod as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Design of PTFE mold

[0043] The polytetrafluoroethylene mold for preparing graphene oxide-doped molecularly imprinted polymer-coated stirring rods consists of three parts: the bottom cover, the main body and the upper cover. The bottom cover is not perforated, and the center of the upper cover is perforated for fixing the glass. The capillary rod is in the center of the mold. The inner diameter of the main part of the mold can be adjusted to obtain GO / MIP coating stirring rods with different coating thicknesses. The length of the mold selected in this example is 2cm, the inner diameter of the main part is 2.5mm, and the outer diameter of the glass capillary rod is 1.1mm, and the thickness of the coating of the stirring rod is calculated to be 700μm.

[0044] (2) Activation of glass capillary rod

[0045] Cut the glass capillary to about 6 cm, seal one end with the flame of an alcohol lamp, and melt the other end into a spherical shape to obtain a glass capillary ...

Embodiment 2

[0057] The stirring rod extraction and desorption process of the graphene oxide-doped molecularly imprinted polymer stirring rod is as follows: the graphene oxide-doped molecularly imprinted polymer stirring rod is placed in 10 mL of the sample solution (adjust the pH of the sample solution to 9.0 with sodium hydroxide solution) , stirring and extracting at 800rpm for 40min, after the extraction, take out the stirring rod, wipe off the solution residue on the surface of the stirring rod with filter paper, transfer it to a solution containing 100μL methanol / 10mmol / L hydrochloric acid (60 / 40, v / v) Ultrasonic desorption in the desorption tube for 20min. The desorbed liquid is filtered through a 0.22 μm filter membrane and used for subsequent high-performance liquid chromatography-ultraviolet (HPLC-UV) detection and analysis; the desorbed stirring bar is placed in 8% acetic acid methanol solution and methanol for 5 minutes, and can be repeated after regeneration. use.

[0058] ...

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Abstract

The invention discloses a graphene oxide doped molecular imprinted polymer stirring rod as well as a preparation method and application thereof. The graphene oxide doped molecular imprinted polymer stirring rod comprises a glass capillary tube, an iron core and an extraction coating; the iron core is arranged in the glass capillary tube with two hotly-sealed ends; and the extraction coating is a graphene oxide doped propranolol molecular imprinted polymer coating which is chemically bonded on the surface of the glass capillary tube. According to the graphene oxide doped molecular imprinted polymer stirring rod, a glass stirring rod which is activated by a sodium hydroxide solution is immersed into a mold containing a graphene oxide doped molecular imprinted prepolymerization solution; and after reaction is finished, the graphene oxide doped molecular imprinted polymer coating stirring rod is taken out. The graphene oxide doped molecular imprinted polymer stirring rod disclosed by the invention can be used for selectively extracting and analyzing medicines, and has the advantages of strong water-phase identification capability, good extraction selectivity, high adsorption capacity, rapid mass transfer rate, good mechanical stability, good heat stability, good chemical stability and the like.

Description

technical field [0001] The invention belongs to the technical field of analytical chemical sample pretreatment, and relates to an adsorption-type extraction stirring rod, in particular to a molecularly imprinted polymer stirring rod doped with graphene oxide and its preparation method and application. Background technique [0002] Stir bar sorptive extraction (SBSE) (Baltussen E., Sandra P., David F., Cramers C. Stir bar sorptive extraction (SBSE), a novel extraction technique for aqueous samples: theory and principles [J]. Journal of Microcolumn Separations, 1999,11(10):737-747) as a new type of sample pretreatment technology, has the characteristics of miniaturization, easy operation, low cost, high extraction efficiency, etc. Compared with solid phase microextraction technology, it avoids the use of Competitive adsorption caused by stirring magnets, larger coating volume enhances the ability to extract and enrich target analytes, and has higher extraction efficiency, so i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/286B01J20/30C08F222/14C08F220/06C08F2/44C08K9/00C08K3/04C08J9/28
Inventor 胡斌范文莹吴晓冉何蔓陈贝贝
Owner WUHAN UNIV
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