A kind of synthetic method of multi-substituted quinoline compound
A synthetic method and compound technology, applied in the direction of organic chemistry, can solve the problems that cannot meet the application requirements in the chemical and pharmaceutical fields, and achieve good application prospects, industrial production potential, and high yield effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0034]
[0035] Under a nitrogen atmosphere, add 100 mmol of the above formula (I) compound, 4 mmol of catalyst L-proline to an appropriate amount of composite solvent (a mixture of DMF and N-ethylpyridine tetrafluoroborate at a volume ratio of 5:1) at room temperature Acetate tert-butyl ester hydrochloride, 50mmol base diisopropanolamine and 10mmol pyridine auxiliary agent 4,4'-dimethyl-2,2'-dipyridyl, then stirred and heated to 60°C, and at this temperature The reaction was stirred for 8 hours.
[0036] After the reaction was completed, filter while it was hot, add saturated aqueous sodium bicarbonate solution to the filtrate, shake fully, then extract three times with ethyl acetate, combine the organic phases, dry the organic phases with anhydrous magnesium sulfate, concentrate under reduced pressure, and filter the residue over Purified by 200-300 mesh silica gel column chromatography using a mixture of acetone and petroleum ether at a volume ratio of 1:2 as the eluent ...
Embodiment 2
[0040]
[0041] Under a nitrogen atmosphere, add 100mmol of the above formula (I) compound, 8mmol of catalyst L-proline to an appropriate amount of composite solvent (a mixture of DMF and N-ethylpyridine tetrafluoroborate at a volume ratio of 5:1) at room temperature Acetate tert-butyl ester hydrochloride, 65mmol base diisopropanolamine and 20mmol pyridine auxiliary agent 4,4'-dimethyl-2,2'-bipyridine, then stirred and heated to 70 ° C, and at this temperature The reaction was stirred for 6 hours.
[0042]After the reaction was completed, filter while it was hot, add saturated aqueous sodium bicarbonate solution to the filtrate, shake fully, then extract three times with ethyl acetate, combine the organic phases, dry the organic phases with anhydrous magnesium sulfate, concentrate under reduced pressure, and filter the residue over Purified by 200-300 mesh silica gel column chromatography, using a mixture of acetone and petroleum ether at a volume ratio of 1:2 as the eluent...
Embodiment 3
[0046]
[0047] Under a nitrogen atmosphere, add 100 mmol of the above formula (I) compound, 6 mmol of catalyst L-proline to an appropriate amount of composite solvent (a mixture of DMF and N-ethylpyridine tetrafluoroborate at a volume ratio of 5:1) at room temperature Acetate tert-butyl ester hydrochloride, 80mmol base diisopropanolamine and 15mmol pyridine auxiliary agent 4,4'-dimethyl-2,2'-bipyridine, then stirred and heated to 80°C, and at this temperature The reaction was stirred for 4 hours.
[0048] After the reaction was completed, filter while it was hot, add saturated aqueous sodium bicarbonate solution to the filtrate, shake fully, then extract three times with ethyl acetate, combine the organic phases, dry the organic phases with anhydrous magnesium sulfate, concentrate under reduced pressure, and filter the residue over Purified by 200-300 mesh silica gel column chromatography using a mixture of acetone and petroleum ether at a volume ratio of 1:2 as the eluent...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More