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A kind of gastric bismuth magnesium granule and preparation method thereof

The technology of magnesium bismuth and granules in stomach is applied to the field of bismuth and magnesium granules and their preparation, which can solve the problems of decreased utilization rate of volatile oil, easy volatilization of volatile oil, etc., and achieves the effects of high utilization rate and excellent curative effect.

Active Publication Date: 2016-05-11
HONGMEI PHARMA CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the volatile oil is easy to volatilize, and the surface oil of the inclusion complex is also high; thus, the utilization rate of the volatile oil is reduced

Method used

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  • A kind of gastric bismuth magnesium granule and preparation method thereof
  • A kind of gastric bismuth magnesium granule and preparation method thereof
  • A kind of gastric bismuth magnesium granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] prescription:

[0049]

[0050] Preparation of the volatile oil of Shichangpu: Put the prescribed amount of pure medicinal materials of Shichangpu into the extraction tank, add about 4 times the amount of water of the medicinal materials, soak for 36 hours, extract the volatile oil with steam distillation, keep the liquid surface boiling, and control the steam pressure below 0.3Mpa , collect the volatile oil of Shichangpu, airtight, please inspect, refrigerate at 2-10°C, and use it for later use after passing the inspection;

[0051] Preparation of inclusion compound of calamus calamus: Take sodium starch octenyl succinate, add boiling water, stir to dissolve, cool to room temperature, and obtain a slurry; add spare volatile oil of calamus calamus to the obtained slurry under stirring, in which octenyl The volume ratio of the amount of sodium starch succinate and the volatile oil extracted from Shichangpu is 10g: 1ml to make colostrum; the colostrum is homogenized to...

Embodiment 2

[0056] prescription:

[0057]

[0058] Preparation of Shichangpu volatile oil: with embodiment 1.

[0059] Preparation of inclusion compound of calamus calamus: Take sodium starch octenyl succinate, add boiling water, stir to dissolve, cool to room temperature, and obtain a slurry; add spare volatile oil of calamus calamus to the obtained slurry under stirring, in which octenyl The volume ratio of the amount of sodium starch succinate and the volatile oil extracted from Acorus calamus is 15g: 1ml to make colostrum; homogenize the colostrum twice to obtain the volatile oil emulsion, wherein the primary pressure is 35MPa, and the secondary pressure is 35MPa. is 12MPa; and then the obtained volatile oil emulsion is spray-dried to obtain the inclusion compound of calamus calamus.

[0060] Pulverize the sucrose in the prescription, pass through a 100-mesh sieve, and set aside;

[0061] Mix the weighed bismuth aluminate, heavy magnesium carbonate, sodium bicarbonate, licorice e...

Embodiment 3

[0064] prescription:

[0065]

[0066]

[0067] Preparation of Shichangpu volatile oil: with embodiment 1.

[0068] Preparation of inclusion compound of calamus calamus: Take sodium starch octenyl succinate, add boiling water, stir to dissolve, cool to room temperature, and obtain a slurry; add spare volatile oil of calamus calamus to the obtained slurry under stirring, in which octenyl The volume ratio of the amount of sodium starch succinate and the volatile oil extracted from Shichangpu is 12g: 1ml to make colostrum; the colostrum is homogenized to obtain a volatile oil emulsion, wherein the primary pressure is 30MPa, and the secondary pressure is 10MPa ; Then the obtained volatile oil emulsion is spray-dried to obtain the inclusion compound of Acorus calamus.

[0069] Pulverize the sucrose in the prescription, pass through a 100-mesh sieve, and set aside;

[0070] Mix the weighed bismuth aluminate, heavy magnesium carbonate, sodium bicarbonate, licorice extract pow...

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Abstract

The invention belongs to the technical field of pharmacy, and specifically relates to stomach bismuth-magnesium granules and a preparation method thereof. The stomach bismuth-magnesium granules are granules prepared by combining main medicines namely bismuth aluminate, heavy magnesium carbonate, sodium bicarbonate, extractum glycyrrhizae powder, Frangulae cortex, fennel, aloe and rhizoma acori graminei, and then adding pharmaceutic adjuvants, wherein the volatile oil extracted from rhizoma acori graminei is included by starch sodium octenylsuccinate to obtain an inclusion compound, and then the inclusion compound is combined with other components. In the preparation method disclosed by the invention, the volatile oil extracted from rhizoma acori graminei is included by starch sodium octenylsuccinate, so that the volatile components of rhizoma acori graminei in the stomach bismuth-magnesium granules are not liable to volatilize, and the utilization rate of the volatile oil is high and superior to that of a beta-cyclodextrin method in the prior art; moreover, the curative effect of the stomach bismuth-magnesium granules prepared by the method is superior to that of the stomach bismuth-magnesium granules prepared by a rhizoma acori graminei cyclodextrin inclusion compound in the prior art.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a gastric bismuth magnesium granule and a preparation method thereof. Background technique [0002] Stomach disease is a common and frequently-occurring disease that seriously endangers human health. It generally refers to gastritis and gastric and duodenal ulcer disease. The initial or mild symptoms are epigastric discomfort, fullness, heartburn, retching, and nausea. A variety of reasons can cause gastric disease, such as diet, environment, genetics, drugs, bacterial and chemical damage, smoking, etc. can all be the cause of gastric disease, resulting in excessive gastric acid secretion and aggravated gastric mucosal damage. Therefore, the drugs for the treatment of gastric diseases can be divided into two categories, one is drugs that neutralize or weaken gastric acid and acid-suppressing drugs H 2 Receptor antagonists; a class of drugs that increase the defenses...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K33/06A61K33/10A61K36/896A61K36/886A61K47/48A61P1/00A61K33/00A61K33/24
Inventor 郭智华车东王丽玲
Owner HONGMEI PHARMA CHINA
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