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Preparation method for nano-hydroxyapatite

A nano-hydroxyapatite and calcium-phosphorus technology, applied in nanotechnology, nanotechnology, chemical instruments and methods, etc., can solve the problems of long reaction time, low production efficiency, slow mass transfer, etc.

Inactive Publication Date: 2015-10-28
NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the chemical precipitation method has advantages over other traditional methods, it still has the problems of slow mass transfer, long reaction time, high energy consumption and low production efficiency.

Method used

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  • Preparation method for nano-hydroxyapatite
  • Preparation method for nano-hydroxyapatite
  • Preparation method for nano-hydroxyapatite

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Prepare 0.25mol / LCa(NO 3 ) 2 4H 2 O, Na 3 PO 4 12H 2 O each 5L raw material, add 80g acetamide to Na 3 PO 4 In the solution, the reaction was carried out in a rotating packed bed at a flow rate of 40L / h and a temperature of 40°C. The rotating speed of the rotating packed bed was 900r / min, and the reaction was carried out by using the supergravity method; the precipitate after the reaction was aged at room temperature After drying for 36 hours, centrifuging, washing and drying, the drying temperature was 100° C., and after drying for 5 hours, nano-hydroxyapatite was obtained, and the yield per pass was 89.3%.

Embodiment 2

[0020] Prepare 0.25mol / LCa(NO 3 ) 2 4H 2 O, Na 3 PO 4 12H 2 O each 5L raw material, add 80g acetamide to Na 3 PO 4 In the solution, the reaction was carried out in a rotating packed bed with a flow rate of 40L / h and a temperature of 60°C. The rotating speed of the rotating packed bed was 1000r / min, and the reaction was carried out by using the supergravity method; the precipitate after the reaction was aged at room temperature After drying for 36 hours, centrifuging, washing and drying, the drying temperature is 100° C., and after drying for 5 hours, nano-hydroxyapatite is obtained, and the single-pass yield is 90.6%.

Embodiment 3

[0022] Prepare 0.25mol / LCa(NO 3 ) 2 4H 2 O, Na 3 PO 4 12H 2 O each 5L raw material, add 80g acetamide to Na 3 PO 4 In the solution, the reaction was carried out in a rotating packed bed at a flow rate of 40L / h and a temperature of 80°C. The rotating speed of the rotating packed bed was 1500r / min, and the reaction was carried out by using the supergravity method; the precipitate after the reaction was aged at room temperature After drying for 36 hours, centrifuging, washing and drying, the drying temperature is 100° C., and after drying for 5 hours, nano-hydroxyapatite is obtained, and the single-pass yield is 66.2%.

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Abstract

The invention provides a preparation method for nano-hydroxyapatite. The preparation method for nano-hydroxyapatite is characterized in that the gravitational method and the chemical precipitation method are combined, and nano-hydroxyapatite is prepared efficiently. Through the control over reaction conditions such as the solution concentration, the solution flow quantity, the reaction temperature and the rotating speed of a rotating packed bed, and then the nano-hydroxyapatite is prepared. The preparation method for nano-hydroxyapatite has the advantages that the production efficiency is high, the cost is low, the equipment is simple, and the technology is stable.

Description

technical field [0001] The invention belongs to the technical field, and relates to a method for preparing nano-hydroxyapatite, in particular to a method for preparing nano-hydroxyapatite by rapid precipitation reaction under supergravity conditions. Background technique [0002] As a bioceramic material, nano-hydroxyapatite has very good biocompatibility. The material can chemically bond with hard tissue in the human body, greatly speeding up the repair and healing of bone defect tissue, and providing a scaffold for the formation of new bone, inducing new bone formation and growth, so nano-hydroxyapatite is often used as Applied to the treatment of human hard tissues, it is an ideal substitute material for human bone repair. The researchers' previous research on it mainly controlled the ratio of product stoichiometry. Later, according to the actual situation, it was found that the microscopic shape and size of the material will also have a great impact on its compatibilit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00
Inventor 张艳辉王志锋尚龙安王东霖阮艳波
Owner NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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