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Method for preparing ethoxy quinoline

A technology of ethoxyquinoline and methyl group, applied in the field of preparing ethoxyquinoline, can solve the problems of polluting the environment, corroding equipment, difficult to reuse, etc., and achieves the effects of high yield and avoiding oxidation

Active Publication Date: 2015-10-28
TAIXING RUITAI CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing method for preparing ethoxyquinoline adopts p-aminophenethyl ether and acetone as raw materials, and adds catalyst and solvent to synthesize, but the final yield of these methods is low, and the acetone used and p-aminophenethyl ether cannot be used in the reaction process. complete conversion, as the temperature rises, the volatilization of acetone will cause certain safety hazards to the operator; in the prior art, acetone is also first converted into the intermediate 4-methyl-3-penten-2-one, but The catalysts used are all alkaline catalysts, which will corrode equipment, pollute the environment, and are difficult to separate and reuse

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  • Method for preparing ethoxy quinoline

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preparation example Construction

[0023] The concrete steps of the described method for preparing ethoxyquinoline are:

[0024] (1) Preparation of intermediate 4-methyl-3-penten-2-one

[0025] a. Add acetone and zeolite to the dry reaction tank, install a thermometer on one side, and connect to the distillation equipment on the other side. Cotton or glass wool is placed at the bottom of the distillation equipment, and a catalyst that is ground into rice grains is built in. The catalyst is 4%-6 % Mg 2+ Mesoporous molecular sieve, the top is covered with cotton, and the top of the distillation equipment is connected to the high-efficiency water condenser. The amount of liquid dripped into the distillation equipment by reflux is the same as the amount of liquid dripped into the reaction tank by the distillation equipment, and the reaction temperature is properly adjusted with the increase of the liquid temperature in the reaction tank;

[0026] b. Put the iodine added into the reaction tank into a frac...

Embodiment 1

[0032] The concrete steps of the described method for preparing ethoxyquinoline are:

[0033] (1) Preparation of intermediate 4-methyl-3-penten-2-one

[0034] a. Add acetone and zeolite to the dry reaction tank, install a thermometer at one side port, and connect the side port with distillation equipment. Cotton or glass wool is placed at the bottom of the distillation equipment, and a catalyst that is ground into rice grains is built in. The catalyst is 4% Mg. 2+ Mesoporous molecular sieve, the top is covered with cotton, and the top of the distillation equipment is connected to the high-efficiency water condenser. After installation, the reaction tank is heated, the reaction temperature is controlled at 160°C, the reaction time is 2h, and the switch of the distillation equipment is adjusted to allow the reflux to drip into the distillation equipment. The amount of liquid dropped into the reaction tank by the distillation equipment is consistent, and the reaction te...

Embodiment 2

[0041] The concrete steps of the described method for preparing ethoxyquinoline are:

[0042] (1) Preparation of intermediate 4-methyl-3-penten-2-one

[0043] a. Add acetone and zeolite to the dry reaction tank, install a thermometer on one side, and connect to the distillation equipment on the other side. Cotton or glass wool is placed at the bottom of the distillation equipment, and a catalyst that is ground to the size of rice grains is built in. The catalyst is 5% Mg 2+ Mesoporous molecular sieve, the top is covered with cotton, and the top of the distillation equipment is connected to the high-efficiency water condenser. After installation, the reaction tank is heated, the reaction temperature is controlled at 170°C, and the reaction time is 3h. Adjust the switch of the distillation equipment to allow the reflux to drip into the distillation equipment. The amount of liquid dropped into the reaction tank by the distillation equipment is consistent, and the reacti...

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Abstract

The invention relates to a method for preparing ethoxy quinoline and belongs to the field of fodder and food. The preparation of the ethoxy quinoline is divided into two steps, namely the preparation of midbody 4-methyl-3-penten-2-ketone and the preparation of a finished product ethoxy quinoline. The method comprises the steps that firstly acetone is transformed into the midbody 4-methyl-3-penten-2-ketone, the potential safety hazards to an operator due to the fact that in the reaction process, the acetone is not reacted completely and volatilized under heating are prevented, and in the transformation process of the 4-methyl-3-penten-2-ketone, by using a catalyst, namely 4%-6% of Mg2+mesoporous molecular sieve, the high-purity 4-methyl-3-penten-2-ketone midbody can be obtained; methylbenzene serves as solvent as well as a water-carrying agent, 'azeotropy' is conducted through the methylbenzene and water generated in reaction, water can be separated, so that the reaction is conducted toward the positive reaction direction, meanwhile, by adding the methylbenzene solvent, an 'inert' solvent gas environment is formed inside a reaction tank, and oxidation of materials is avoided; by means of the combined action of the methylbenzene and toluenesulfonic acid, the produced ethoxy quinoline can reach the standards of feed grade ethoxy quinoline.

Description

technical field [0001] The invention relates to a method for preparing ethoxyquinoline, which belongs to the field of feed and food. Background technique [0002] Ethoxyquinoline is recognized as the most effective, economical and practical feed antioxidant in the world. It has the characteristics of high antioxidant efficiency, safety and non-toxicity, convenient use, and no accumulation in animals. It is suitable for full-price feed , Add fat products and fish meal, it can prevent feed oxidation and corruption, maintain animal protein feed energy, prevent vitamin A, vitamin E, lutein from being destroyed during feed mixing and storage, and prevent fat-soluble vitamins and pigments from being oxidized loss, inhibit self-heating, improve the quality of fishmeal, and at the same time increase the weight of the animals raised, improve the conversion rate of the feed, promote the full action of the animal on the pigment, prevent vitamin A, E deficiency, prolong the shelf life o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D215/20
CPCC07D215/20
Inventor 丁龙军任云华黄珍宏孙汝友王春民
Owner TAIXING RUITAI CHEM
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