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Method for preparing amlodipine atorvastatin calcium tablets

A technology of atorvastatin calcium and amlodipine, which is applied in the direction of pill delivery, cardiovascular system diseases, bulk delivery, etc., can solve the problems of inaccessibility, and achieve the effects of saving time, improving drug efficacy, and improving dissolution rate

Inactive Publication Date: 2015-11-04
BEIJING JIALIN PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] Amlodipine atorvastatin calcium tablet is owing to involve the dissolution rate of two kinds of compositions, in order to reach synergistic effect, the ratio of both dissolution rates should be between 85~95:90~100 after testing, and with above-mentioned existing None of the amlodipine atorvastatin calcium tablets prepared by this technology can meet the above requirements

Method used

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  • Method for preparing amlodipine atorvastatin calcium tablets
  • Method for preparing amlodipine atorvastatin calcium tablets
  • Method for preparing amlodipine atorvastatin calcium tablets

Examples

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Embodiment 1

[0065] Formula of the present invention and preparation method are as follows:

[0066] Preparation of Atorvastatin Calcium Granules:

[0067] prescription:

[0068]

[0069] Preparation:

[0070] Ultrafine pulverization: Weigh the prescribed amount of atorvastatin calcium, mix it with the prescribed amount of lactose, and ultrafinely pulverize it so that 90% of the particle size is below 50 microns.

[0071] Preparation of adhesive: dissolve polysorbate 80 in 95% ethanol, then add hydroxypropyl cellulose, stir until the solution becomes clear, and set aside.

[0072] Granulation: Mix atorvastatin calcium, lactose, calcium carbonate, microcrystalline cellulose, pregelatinized starch, and sodium carboxymethyl starch in a high-shear granulator, and add binder ① to granulate.

[0073]Drying: The granules are dried in boiling drying equipment.

[0074] The preparation of amlodipine besylate granule:

[0075]

[0076] The preparation method of amlodipine besylate granule...

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Abstract

The invention relates to a method for preparing amlodipine atorvastatin calcium tablets. According to the method, the superfine grinding process is adopted, atorvastatin calcium and amlodipine besylate are subjected to the superfine grinding respectively, then the atorvastatin calcium and amlodipine besylate are mixed with a defined amount of auxiliary materials for tabletting, and according to a sample prepared through the process, compared with the prior art, the dissolution rate is happened to be within 85-95:90-100.

Description

Technical field: [0001] The invention relates to a formulation and a preparation method of a pharmaceutical composition, in particular to a preparation method of amlodipine atorvastatin calcium tablets. Background technique: [0002] Amlodipine Atorvastatin Calcium Tablets is a compound drug preparation suitable for patients who need amlodipine and atorvastatin combined therapy. [0003] Among them, amlodipine has the following therapeutic effects: [0004] 1. Hypertension Amlodipine is suitable for the treatment of hypertension. It can be used alone or in combination with other antihypertensive drugs. [0005] 2. Coronary heart disease (CAD) chronic stable angina pectoris Amlodipine is suitable for symptomatic treatment of chronic stable angina pectoris. It can be used alone or in combination with other antianginal drugs. Vasospastic angina (Prinzmetal's or variant angina) Amlodipine is indicated for the treatment of confirmed or suspected vasospastic angina. It can be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K31/40A61K47/38A61K9/16A61P9/12
Inventor 崔林玉张建强
Owner BEIJING JIALIN PHARM INC
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