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Transdermal delivered pharmaceutical composition with pain reliving and inflammation preventing effects, applications and preparation method thereof

An analgesic and anti-inflammatory composition technology, which is applied in the field of pharmaceutical compositions with analgesic and anti-inflammatory effects for transdermal administration, can solve problems such as infeasibility, and achieve safe and effective compliance, convenient administration, and improved The effect of transdermal absorption effect

Active Publication Date: 2015-11-11
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is also a report that Chuanxiong oil promotes the penetration of paeonol, but this report uses 0.5mL to treat the skin for 12 hours before administering it, which is obviously not feasible in practical applications (China Pharmaceutical Industry, 2013, 22 (5): 6-7 )

Method used

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  • Transdermal delivered pharmaceutical composition with pain reliving and inflammation preventing effects, applications and preparation method thereof
  • Transdermal delivered pharmaceutical composition with pain reliving and inflammation preventing effects, applications and preparation method thereof
  • Transdermal delivered pharmaceutical composition with pain reliving and inflammation preventing effects, applications and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Ligusticum chuanxiong oil is to the transdermal penetration promoting effect of ibuprofen

[0029] Using 40% ethanol-physiological saline as a solvent, prepare 0.4%, 0.8% and 1.2% Chuanxiong oil solutions respectively, add ibuprofen to make the concentration 2mg / mL, and obtain a mixed solution. Prepare 2 mg / mL ibuprofen solution (without penetration enhancer) in the same way as a control. Take 1.5 mL of each of the above solutions and place them on the Franz diffusion cell. Using the isolated rat abdominal skin as the skin model and 40% ethanol-physiological saline as the receiving solution, measure the concentration of ibuprofen in the receiving solution at different time points, and calculate the cumulative The permeation rate was used to investigate the transdermal effect of Chuanxiong oil on ibuprofen, such as figure 1 shown. It can be seen that after the addition of Chuanxiong oil, the transdermal absorption rate and cumulative permeation volume o...

Embodiment 2

[0030] The preparation of embodiment 2 ibuprofen Chuanxiong oleogel

[0031] Sprinkle 3g of Carbomer 940 on 40g of distilled water, let it sit overnight at room temperature, fully swell, then add 4g of triethanolamine, stir well, and set aside. Take another 2g of ibuprofen and 8g of Chuanxiong oil, add 25mL of absolute ethanol, mix well, and set aside. Slowly add the latter to the former, stir while adding, add distilled water to 100g, stir evenly, pack separately, and obtain.

Embodiment 3

[0032] The preparation of embodiment 3 ibuprofen Chuanxiong oleogel

[0033] The preparation of ibuprofen Chuanxiong oil gel is different from Example 2 in that the consumption of Chuanxiong oil is 12g, and the carbomer is carbomer 934.

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PUM

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Abstract

In the prior art, volatile clove oil does not have a transdermal osmosis promoting effect for ibuprofen; evodia oil and saposhnicovia divaricata oil have the transdermal osmosis promoting effect, but the pain relieving and inflammation preventing effects of the evodia oil and saposhnicovia divaricata oil are not prominent; so azone compounds are still used as the transdermal osmosis promoter for ibuprofen at present. The provided pharmaceutical composition is composed of 1 to 80 parts by weight of ligusticum wallichii oil and 1 to 10 parts by weight of ibuprofen. The invention further provides an external preparation containing the pharmaceutical composition, preferably the preparation can be made into gel and cream, and gel is the most preferable. The invention also provides a preparation method of the gel. For the first time, people find that ligusticum wallichii oil has a prominent transdermal osmosis promoting effect for ibuprofen; furthermore, ligusticum wallichii oil has pain relieving and inflammation preventing activities and transdermal absorption effect and is capable of generating a synergetic effect on preventing inflammation and relieving pains with ibuprofen, while common osmosis promoters cannot generate a synergetic effect with ibuprofen, and the ligusticum wallichii oil is much safer than the common osmosis promoter (azone) as a transdermal osmosis promoter.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition with analgesic and anti-inflammatory effects for transdermal administration, an external preparation prepared by using the composition and a preparation method thereof. Background technique [0002] Ibuprofen is an analgesic and anti-inflammatory drug commonly used in clinical practice. It is recognized as the first-choice anti-inflammatory drug for children. The route of administration is mainly oral, including tablets, capsules, suspensions, etc., and its side effects are mainly gastrointestinal reactions. Such as stomach burning or indigestion, stomach pain or discomfort (gastrointestinal irritation or ulcer formation), nausea, vomiting, etc., the incidence rate can reach 3~9%. Making ibuprofen into external preparations can overcome the adverse reactions of oral administration, and directly act on the affected area, such as commercially available...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/236A61K47/44A61P29/00A61K31/192
Inventor 陈军段金廒顾薇刘培吴叶鸣
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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