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Anti-bacterial and anti-inflammatory natural biological material and application thereof

A biomaterial and cell technology, applied in medical science, prosthesis, etc., can solve the problems of poor long-term antibacterial effect, limited clinical application, inconvenient operation, etc., to improve the degradation rate and mechanical properties, improve mechanical properties, and slow down degradation. rate effect

Inactive Publication Date: 2015-11-11
CHONGQING ACAD OF ANIMAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned hydrogels still have deficiencies: first, its composition is only composed of collagen, and its structural composition is different from that of the natural extracellular matrix; second, the physical properties of the hydrogel are brittle and fragile, and it is inconvenient to operate, which limits its application on body surface wounds. Clinical Application in Restoration
The use of nano-silver for antibacterial is a commonly used antibacterial method at present, but most of them use physical adsorption method, and its disadvantage is that it is released quickly after meeting water, and the long-term antibacterial effect is poor.
In addition, natural biomaterials with both antibacterial and anti-inflammatory functions have not been reported so far. Therefore, the purpose of the present invention is to solve the above problems and provide an antibacterial and anti-inflammatory natural biomaterial that can promote tissue regeneration and repair for body surface wound repair.

Method used

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  • Anti-bacterial and anti-inflammatory natural biological material and application thereof
  • Anti-bacterial and anti-inflammatory natural biological material and application thereof
  • Anti-bacterial and anti-inflammatory natural biological material and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A kind of biological material, its preparation method comprises the following steps:

[0041] 1. Preparation of PSIS

[0042] From obtaining fresh porcine small intestine, the serosa layer and muscular layer of the small intestine were firstly removed by mechanical means, rinsed with normal saline repeatedly; soaked in methanol and chloroform (1:1, V / V) degreasing solution for 12 hours, and rinsed with deionized water to remove the organic solvent; subsequently, soak the SIS in 0.05% trypsin / 0.05% ethylenediaminetetraacetic acid solution, digest at room temperature for 12 hours, and wash repeatedly with normal saline solution to remove trypsin; place the SIS in 0.5% dodecane Shake in sodium disulfite (SDS) saline for 4 hours, and rinse thoroughly with saline solution to remove detergent. Soak the treated SIS in 0.5% acetic acid solution overnight, crush it with a beater, add pepsin at 4°C for 2 days, and then filter; the filtrate is salted out twice and centrifuged to ...

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Abstract

The invention provides a biological material which is prepared from small intestinal submucosa (SIS) and is characterized by containing nano silver, the material is of a porous structure, pores are mutually through, and the original form can be restored if the volume compression is more than 85%. The biological material provided by the invention has anti-inflammatory and anti-bacterial functions and is free of cytotoxicity and good in biocompatibility.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to an antibacterial and anti-inflammatory natural biological material and its application. Background technique [0002] Tissue regeneration and repair is an important research topic in modern medicine. The basic structure of human tissue is composed of cells and extracellular matrix, and the interaction between cells and extracellular matrix is ​​the key to the regeneration and repair of wounded tissues. Provide extracellular matrix for the defective tissue, which can promote the surrounding healthy cells to enter the defective tissue to play a repairing role. However, human extracellular matrix is ​​restricted by sources, ethics, etc., and its use is limited. [0003] Small intestinal submucosa extracellular matrix (smallintestinalsubmucosa, SIS), as a natural extracellular matrix material, is similar to human extracellular matrix in composition and structure, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/56A61L27/50A61L27/44
Inventor 葛良鹏黄勇丁玉春刘雪芹游小燕林保忠
Owner CHONGQING ACAD OF ANIMAL SCI
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