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Magnesium or magnesium alloy surface treatment method capable of controlling degradation speed

A surface treatment and degradation control technology, which is applied in the field of surface treatment of magnesium or magnesium alloys, can solve the problems of fast hydrogen evolution, affecting clinical treatment effects and human health, and rapid degradation, and achieves low price and excellent biocompatibility , resource-rich effect

Active Publication Date: 2015-11-25
BEIJING NATON TECH GRP CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to overcome the shortcomings of the existing magnesium or magnesium alloy materials in the human physiological environment, the degradation is too fast, the hydrogen evolution rate is too fast, and the clinical treatment effect and human health are affected. The purpose of the present invention is to provide a magnesium or magnesium alloy that can control the degradation rate. Surface treatment method

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0032] Coating treatment of embodiment 1 medical magnesium-calcium alloy

[0033] 1. Pretreatment: Use sandpaper to grind the medical magnesium-calcium alloy, and then use 1μm and 0.3μm Al 2 o 3 The polishing powder is used for polishing, and then the polished magnesium-calcium alloy is ultrasonically cleaned in absolute ethanol for 5-10 minutes, and then cleaned with N 2 Blow dry; soak the dry magnesium-calcium alloy in a 20% NaOH solution for passivation for 24h, then clean it with deionized water, N 2 blow dry.

[0034] 2. Preparation of mussel protein solution: before use, dilute mussel protein to 1 mg / mL with 1% citric acid buffer solution, adjust its pH to 4.6 with NaOH solution, and set aside.

[0035] 3. Soak the magnesium-calcium alloy pretreated in step 1 in the mussel protein solution in step 2 for 1 hour, so that the mussel protein can be fully adsorbed on the surface of the magnesium-calcium alloy to form a protein film layer with a thickness of about 3-5 μm ....

Embodiment 2

[0037] Coating treatment of embodiment 2 medical magnesium-calcium alloy

[0038]1. Pretreatment: Use sandpaper to grind the medical magnesium-calcium alloy, and then use 1μm and 0.3μm Al 2 o 3 The polishing powder is used for polishing, and then the polished magnesium-calcium alloy is ultrasonically cleaned in absolute ethanol for 5-10 minutes, and then cleaned with N 2 Blow dry; soak the dry magnesium-calcium alloy in a 20% NaOH solution for passivation for 24h, then clean it with deionized water, N 2 blow dry.

[0039] 2. Preparation of mussel protein solution and nano-cerium oxide solution: before use, dilute mussel protein to 1 mg / mL with 1% citric acid buffer solution, adjust its pH to 4.6 with NaOH solution, and set aside; A nano-cerium oxide solution with a concentration of 500ppm was prepared in deionized water.

[0040] 3. Place the magnesium-calcium alloy pretreated in step 1 in the mussel protein solution of step 2 and soak for 1 hour, and then soak it in the n...

Embodiment 3

[0043] In step 3, the magnesium-calcium alloy is placed in the mussel protein solution and soaked for 1 hour to apply a layer of protein film, then dry it naturally for 2 hours, and then apply the second layer of protein film according to the same operation, and the other steps are the same as in Example 1. Form a double protein film layer on the surface of the magnesium-calcium alloy.

[0044] After the above coating treatment, the electrochemical impedance spectroscopy test shows that the corrosion degradation rate of the magnesium-calcium alloy is reduced by about 1 / 4 of that before the coating.

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Abstract

The invention provides a magnesium or magnesium alloy surface treatment method capable of controlling the degradation speed. A protein film layer is formed on the surface of magnesium or a magnesium alloy through mussel adhesive protein, or a composite film layer is formed on the surface of the magnesium or the magnesium alloy through the mussel adhesive proteins and nano cerium oxide particles. The degradation speed of the magnesium or the magnesium alloy material treated through the surface treatment method can be obviously changed in the physiological environment. According to the treatment method, the adopted mussel protein and nano cerium oxide material have excellent biocompatibility, no harm is caused to the human body, and the method can be applied clinically. The treatment method is simple, easy to implement, high in operability, rich in raw material resource, low in price and capable of achieving sustainable industrial application.

Description

technical field [0001] The invention relates to the field of metal materials, in particular to a surface treatment method for magnesium or magnesium alloys that can control the degradation rate. Background technique [0002] Self-ablative absorbable human implant materials are an important category of biomaterials. This kind of material can be gradually ablated and absorbed in the human body, and does not need to be operated again to remove the fixing parts, which can reduce the pain caused by the operation or the discomfort caused by the implanted material left in the body. [0003] Magnesium and magnesium alloys are potential absorbable implant materials for the human body. Compared with other biomaterials, they have abundant resources, magnesium density, elastic modulus and other comprehensive mechanical properties similar to human bones, excellent biocompatibility and Biodegradability and other advantages can be used as human implants such as bone nails or brackets. Ma...

Claims

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Application Information

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IPC IPC(8): C23C22/02C23C22/07C23C22/73
Inventor 林昌健侯瑞青杨云张艳梅林理文
Owner BEIJING NATON TECH GRP CO LTD
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