Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine elution balloon

A technology of balloons and medicines, applied in the direction of medicine equipment, stents, and other medical equipment, etc., can solve the problems of small applicable population, toxicity, and large limitations, and achieve the effect of firm coating, easy absorption, and prevention of thrombosis

Active Publication Date: 2015-12-02
王显
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the compound drug-eluting balloon of paclitaxel and Uvitamin has been clinically marketed, but there are the following defects: first, as a contrast agent, Uvitamin has certain toxicity and may cause relatively large side effects when used. Yes, when using Uvism, the applicable population is relatively small, especially patients with hyperthyroidism, patients allergic to iodine contrast medium, patients with severe liver and kidney damage, and patients with cardiac insufficiency. The clinical application of capsule is relatively limited

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine elution balloon
  • Medicine elution balloon
  • Medicine elution balloon

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present invention provides a drug eluting balloon, the surface of the balloon body is provided with a drug coating, and the drug coating components include paclitaxel and hirudin in a mass ratio of 1:1. The weight of the drug coating of the balloon is 3ug / mm 2 .

[0028] The preparation method of the drug eluting balloon of the present invention includes the following steps:

[0029] Step 1: Take paclitaxel and hirudin with a mass ratio of 1:1, add the dry hirudin powder to methanol at a ratio of 6-8 mg / ml to dissolve, and then add a formula amount of paclitaxel to prepare a paclitaxel and hirudin solution;

[0030] Step two, using vacuum spraying combined with ultrasonic atomization technology to spray paclitaxel and hirudin solution on the surface of the eluting balloon. The specific operation is as follows: first spray paclitaxel and hirudin solution to the specified weight range, and then air dry for 10-30 minutes. The weight of the drug coating of the balloon is 3ug...

Embodiment 2

[0032] The present invention provides a drug eluting balloon, the surface of the balloon body is provided with a drug coating, and the components of the drug coating include paclitaxel and hirudin in a mass ratio of 2:1. The weight of the drug coating of the balloon is 3ug / mm 2 .

[0033] The preparation method of the drug eluting balloon of the present invention includes the following steps:

[0034] Step 1. Take paclitaxel and hirudin with a mass ratio of 2:1, add paclitaxel to methanol at a ratio of 18-20mg / ml to prepare a paclitaxel solution; add dry hirudin powder to methanol at a ratio of 6-8mg / ml to make it Hirudin solution; the hirudin solution is made by dissolving dry hirudin powder with methanol;

[0035] Step two, using vacuum spraying combined with ultrasonic atomization technology to spray paclitaxel solution and hirudin solution on the surface of the eluting balloon. The specific operation is as follows: first spray the paclitaxel solution to reach the specified weig...

Embodiment 3

[0037] The present invention provides a drug eluting balloon, the surface of the balloon body is provided with a drug coating, and the components of the drug coating include paclitaxel and hirudin in a mass ratio of 3:1. The weight of the drug coating of the balloon is 8ug / mm 2 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a medicine elution balloon. The surface of the balloon is coated with medicine; the medicine coating comprises a medicine capable of inhibiting endotheliosis and a first medicine in a mass ratio of (0.5 to 20): 1, and the first medicine is one or more of hirudin and hirudin derivatives. Two or more components are smeared on the medicine elution balloon, by utilizing the traditional Chinese medicine compatibility toxicity reducing and efficacy enhancing theory, the blood vessel smooth muscle cell proliferation can be maximally inhibited, the blood vessel endothelialization process is minimally inhibited, and a purpose of effectively treating stenotic pathologic change as well as acute thrombosis, sub-acute thrombosis or late stent thrombosis can be finally achieved.

Description

Technical field [0001] The invention relates to a composite drug eluting balloon. More specifically, the present invention relates to a compound drug-eluting balloon of paclitaxel and hirudin. Background technique [0002] Percutaneous coronary intervention (PCI) has become the standard treatment for stenotic coronary artery disease. However, the incidence of short and mid-term restenosis after balloon dilatation and traditional stent placement is 5%-60% , Which severely limits the development of PCI. With the in-depth study of the mechanism of restenosis after coronary interventional therapy and the successful development of drug-coated stents (DES), it is possible to prevent restenosis with DES. Even so, there is still a 10%-20% restenosis rate after DES implantation. Some DES did not even reduce the incidence of major cardiovascular adverse events. Delayed stent thrombosis has become the focus of attention. The drug eluting balloon (DEB) was born because of its ability to d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61F2/82A61M31/00
Inventor 王显
Owner 王显
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com