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Chloramphenicol molecularly imprinted polymer and preparation method thereof

A technology of molecular imprinting and polymers, applied in alkali metal compounds, chemical instruments and methods, and other chemical processes, to achieve the effects of easy control of reaction conditions, simple operation, and long service life

Active Publication Date: 2015-12-02
XUZHOU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the case of large-scale precision instruments that are difficult to compare with developed countries, improving the level of sample pretreatment and reducing impurity interference is an effective way to improve the sensitivity of the detection method, but there are very few domestic reports on this aspect.

Method used

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  • Chloramphenicol molecularly imprinted polymer and preparation method thereof
  • Chloramphenicol molecularly imprinted polymer and preparation method thereof
  • Chloramphenicol molecularly imprinted polymer and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] Example 1 Research on the Removal Method of Chloramphenicol in Chloramphenicol Molecularly Imprinted Polymer

[0031] 1) Soxhlet extraction method

[0032] With methacrylic acid (MAA) as a functional monomer, EDMA as a crosslinking agent, AIBN as an initiator, the MIPs prepared by thermal polymerization with a CAP content of 1.296g are put into the extraction chamber of a Soxhlet extractor, Add 150mL of methanol and adjust the temperature of the constant temperature water bath so that the methanol in the extraction chamber is evacuated every 45min, and 50uL of the extract is taken every 4 hours to measure the content of CAP and calculate the total extraction of CAP.

[0033] In addition, the same weight of MIPs prepared by the same method was put into another Soxhlet extractor, and acetonitrile was used as the extracting liquid, and the content of CAP was determined and the total extraction amount of CAP was calculated in the same way.

[0034] Table 1 The relation...

Embodiment 2

[0048] Embodiment 2 methacrylic acid is the optimization of the preparation condition of functional monomer

[0049] 1) Influence of porogen

[0050] The porogen determines the degree of bonding between the template molecule and the functional monomer, and also affects the hole structure of the molecularly imprinted polymer, thereby affecting its matching with the target molecule in terms of spatial structure. In order to investigate the influence of the porogen, Dissolve 161.55mg CAP in 2.5mL of methanol, acetonitrile, acetone and tetrahydrofuran, add 0.17mL of MAA as a functional monomer, add 1.888mL of DMA and 23.16mg of AIBN after fully reacting, mix well and transfer to an ampoule, ultrasonication, nitrogen deoxygenation , sealed, and placed in a constant temperature water bath at 60°C for 24 hours to react to obtain a polymer. After fully extracting CAP, the binding ability of the polymers to CAP was determined respectively (B). The results are shown in Table 4.

[...

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Abstract

The invention discloses chloramphenicol molecularly imprinted polymer and a preparation method thereof. The preparation method includes: taking chloramphenicol as template molecule and methylacrylic acid as functional monomer to form host-guest complex; adding a crosslinking agnet EDMA for free radical copolymerization; using solvent methanol and acetic acid mixed liquid to precipitate polymer out of solvent to obtain the chloramphenicol molecularly imprinted polymer, wherein mole ratio of CAP, methylacrylic acid and EDMA is 1:0.5:20. The chloramphenicol molecularly imprinted polymer produced by the method has quite high selectivity and specificity, high stability, long service life and high resistance to severe environment. The chloramphenicol molecularly imprinted polymer is low in cost, simple to operate and easy in reaction condition control.

Description

technical field [0001] The invention belongs to the technical field of molecularly imprinted polymer preparation and specifically designs a chloramphenicol molecularly imprinted polymer and a preparation method thereof. Background technique [0002] In recent years, countries around the world have paid more and more attention to food safety and hygiene, and the issue of veterinary drug residues in animal-derived foods occupies an important position in food safety and hygiene. Pollution incidents of veterinary drugs generally involve a wide range of areas, have great social impact, and cause serious economic losses. In international trade, it has become an important means for developed countries to implement technical barriers to third world countries. In order to protect people's life safety and health and break the technical barriers of developed countries such as Europe and the United States, in addition to strengthening the management of veterinary drug use and animal br...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F220/06C08J9/26B01J20/26B01J20/28B01J20/30
Inventor 唐仕荣宋慧刘全德陈尚龙高兆建李勇刘恩岐朱伶俐王宇金晶
Owner XUZHOU UNIV OF TECH
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