Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device

A technology of injection equipment and microneedles, applied in the directions of microneedles, hypodermic injection devices, needles, etc., can solve problems such as difficulty in accurately controlling the dosage of microneedles, inability to solve differences, differences in penetration depth, etc., and achieve precise control The effect of microneedle dosing

Active Publication Date: 2015-12-09
厦门薇针医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest disadvantage of tapping the microneedles into the skin with your hands is that each person uses different strengths, resulting in significant differences in the penetration depth. different
Spring-based automatic needle injectors can improve needle insertion repeatability, but do not account for skin-to-skin variability
Because the patch microneedle is attached to the patch base, part of the microneedle medicine stays on the surface of the skin along wit

Method used

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  • Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device
  • Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device
  • Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Such as figure 1 As shown, a microneedle injection bullet includes a microneedle array film 1 and a substrate 2, the microneedle array film 1 includes a film base and a microneedle array on the front side of the film base, and the substrate 2 has an array of through holes aligned with the microneedle array , the film base of the microneedle array film 1 is fixed on the substrate 2, and each microneedle of the microneedle array is inserted into the through holes of the through hole array.

[0039] The microneedles of the microneedle array film 1 are dissolvable microneedles, and the dissolvable microneedles include at least one soluble polymer, which can be selected from silk fibroin, collagen, gelatin, hydrogel, carboxymethyl Cellulose, hydroxypropyl methylcellulose, chondroitin sulfate, glycogen, dextrin, amylose, hyaluronic acid, chondroitin sulfate, polylactic acid-glycolic acid copolymer, polylactic acid-glycolic acid copolymer, poly Ethanol esters, polyvinyl alcoh...

Embodiment 2

[0056] Such as figure 2 As shown, a microneedle injection bomb, compared with embodiment 1, the microneedle injection bomb also includes a cover plate 6, the cover plate 6 is located on the back of the microneedle array film 1, and the cover plate 6 is connected to the substrate 2 to form a microneedle injection bomb. The shell of the needle array film 1, the connection mode between the cover plate 6 and the substrate 2 is threaded connection or dovetail groove clamping, the microneedle array film 1 is sandwiched between the cover plate 6 and the substrate 2, and the cover plate 6 has a The through-hole arrays on the cover plate 6 and the through-hole arrays on the substrate 2 have the same size, and the through-hole arrays on the cover plate 6 and the substrate 2 are aligned up and down and combined to form a cylindrical array. Each cylinder of ® contains a microneedle like a sandwich.

[0057] There is a connection structure 61 on the cover plate 6 , and the microneedle in...

Embodiment 3

[0065] A kind of microneedle injection equipment, comprises the microneedle injection bomb of embodiment 1 and embodiment 2 and microneedle propulsion device, microneedle injection bomb is installed in the injection port of microneedle propulsion device, and microneedle propulsion device is microneedle propulsion device based on high-pressure gas. Needle propulsion device, the microneedle propulsion device based on high-pressure gas applies high-pressure gas to the back of the microneedle injection bomb, and the high-pressure gas pushes the microneedle away from the microneedle array film 1, presses into the skin, and completely passes through biological barriers, such as skin, tissue Or the cell membrane, the microneedle begins to dissolve the wrapped drug after entering, and the drug completely enters the skin to degrade and absorb, so as to achieve the purpose of precisely controlling the dosage of the microneedle.

[0066] Such as Figure 5 As shown, the microneedle propul...

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Abstract

The invention relates to the technical field of microneedle injection of cutaneous penetration, in particular to a microneedle injection bullet, a manufacturing method thereof and a microneedle injection device. The microneedle injection bullet comprises a microneedle array thin film and a substrate. The microneedle array thin film comprises a thin film substrate and a microneedle array on the front face of the thin film substrate. The substrate is provided with a through hole array aligned to the microneedle array. The thin film substrate of the microneedle array thin film is fixed to the substrate. Each microneedle of the microneedle array is embedded into a through hole of the through hole array. The microneedle injection device matched with the microneedle injection bullet comprises the microneedle injection bullet and a microneedle propelling device. The microneedle propelling device separates the microneedles of the microneedle array from the microneedle array thin film and presses the microneedles into skin. The microneedle injection device has the advantages that when the microneedle injection bullet is used for injection, and the microneedles are separated from the microneedle array thin film, so that the microneedles completely enter the skin, medicine contained in the microneedles is completely dissolved and released, and the purpose of precisely controlling the microneedle administration dosage is achieved.

Description

technical field [0001] The invention relates to the technical field of microneedle injection for transdermal administration, in particular to a microneedle injection bullet for transdermal administration, a preparation method thereof and a microneedle injection device. Background technique [0002] Transdermal administration refers to the administration of drugs through the surface of the skin. Drugs pass through the barriers of all layers of the skin and are absorbed into the systemic circulation through capillaries to produce systemic or local therapeutic effects. In principle, this transdermal drug delivery method is the same drug delivery method as subcutaneous injection or intravenous infusion, but it has the advantages of being more painless, safer, more stable and better adaptable to patients than the traditional injection drug delivery method. In the transdermal drug delivery technology, the drug relies on the concentration gradient of the drug as the driving force,...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61K9/00
CPCA61K9/0021A61K47/36A61M37/0015A61M2037/0023A61M2037/0046A61M2037/0053
Inventor 游学秋曹小平薛树斌
Owner 厦门薇针医药科技有限公司
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