Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device

Abstract

The invention relates to the technical field of microneedle injection of cutaneous penetration, in particular to a microneedle injection bullet, a manufacturing method thereof and a microneedle injection device. The microneedle injection bullet comprises a microneedle array thin film and a substrate. The microneedle array thin film comprises a thin film substrate and a microneedle array on the front face of the thin film substrate. The substrate is provided with a through hole array aligned to the microneedle array. The thin film substrate of the microneedle array thin film is fixed to the substrate. Each microneedle of the microneedle array is embedded into a through hole of the through hole array. The microneedle injection device matched with the microneedle injection bullet comprises the microneedle injection bullet and a microneedle propelling device. The microneedle propelling device separates the microneedles of the microneedle array from the microneedle array thin film and presses the microneedles into skin. The microneedle injection device has the advantages that when the microneedle injection bullet is used for injection, and the microneedles are separated from the microneedle array thin film, so that the microneedles completely enter the skin, medicine contained in the microneedles is completely dissolved and released, and the purpose of precisely controlling the microneedle administration dosage is achieved.

Description

technical field [0001] The invention relates to the technical field of microneedle injection for transdermal administration, in particular to a microneedle injection bullet for transdermal administration, a preparation method thereof and a microneedle injection device. Background technique [0002] Transdermal administration refers to the administration of drugs through the surface of the skin. Drugs pass through the barriers of all layers of the skin and are absorbed into the systemic circulation through capillaries to produce systemic or local therapeutic effects. In principle, this transdermal drug delivery method is the same drug delivery method as subcutaneous injection or intravenous infusion, but it has the advantages of being more painless, safer, more stable and better adaptable to patients than the traditional injection drug delivery method. In the transdermal drug delivery technology, the drug relies on the concentration gradient of the drug as the driving force,...

AI Technical Summary

Problems solved by technology

The biggest disadvantage of tapping the microneedles into the skin with your hands is that each person uses different strengths, resulting in significant differences in the penetration depth. different

Spring-based automatic needle injectors can improve needle insertion repeatability, but do not account for skin-to-skin variability

Because the patch microneedle is attached to the patch base, part of the microneedle medicine stays on the surface of the skin along with the base of the patch, and is not dissolved and absorbed by the human body. Due to the differences in individual skin thickness and skin elasticity, it remains on the surface of the skin during use. The ratio of the upper half of the microneedle body that cannot be dissolved is different, resulting in a different amount of microneedle drug that can be absorbed during each injection, so it is difficult to accurately control the amount of microneedle administration

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