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Biodegradable medical temperature-sensitive hydrogel and preparing method thereof

A temperature-sensitive hydrogel, biodegradable technology, applied in the fields of fine chemicals and materials science, can solve the problems of application limitation and low gel rupture strength, and achieve the effect of improving solubility and strong rupture resistance.

Inactive Publication Date: 2015-12-09
SHANDONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the use of hydrophilic two-armed polyethylene glycol, the temperature-sensitive gel formed by the aqueous solution of the product has fewer cross-linking points of hydrogen bonds, and the rupture strength of the gel is lower, so the application is greatly restricted.

Method used

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  • Biodegradable medical temperature-sensitive hydrogel and preparing method thereof
  • Biodegradable medical temperature-sensitive hydrogel and preparing method thereof
  • Biodegradable medical temperature-sensitive hydrogel and preparing method thereof

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preparation example Construction

[0033] The invention also discloses a method for preparing a temperature-sensitive hydrogel, comprising the following steps:

[0034] (1) Mix hydrophilic 3-arm-PEG with lactide and glycolide, and then add a catalyst accounting for 0.05-0.5% of the mass fraction of the mixture. Vacuum first, then nitrogen, then vacuum, repeat 3 times, and finally under the conditions of vacuum degree of 10-30Pa and polymerization temperature of 110-150℃, melt ring-opening polymerization for 12-48h to obtain 3-arm - PEG-PLGA block crude product;

[0035] Wherein the molecular weight of the three-arm polyethylene glycol 3-arm-PEG is 400-50000, PLGA is glycolide and lactide copolymer, and the mass ratio of lactide and glycolide is 2:1-20 : 1, the mass ratio of the mass of the sum of lactide and glycolide to the three-arm polyethylene glycol is 1.2:1~4:1;

[0036] (2) Dissolve the crude product with ice water at 0-5°C, heat up to precipitate solids, the upper limit of temperature rise is 60-80°C,...

Embodiment 1

[0039] Add 40017.5g of three-armed polyethylene glycol into the round bottom flask, then add 20g of D,L-lactide and 1g of glycolide, and then add 0.02g of stannous octoate as a catalyst. Vacuum first, then feed nitrogen, and then vacuum again, repeat 3 times, and finally react for 48 hours under the conditions of vacuum degree of 10 Pa and polymerization temperature of 110°C.

[0040] The product was dissolved in distilled water at 5°C, heated to 60°C to precipitate the copolymer and the water layer was discarded, and the operation was repeated three times to remove unreacted monomers and low-molecular water-soluble substances. The resulting copolymer was freeze-dried for 48 hours at a freeze-drying vacuum of 1.5 Pa and a temperature of -30°C to obtain a purified 3-arm-PEG-PLGA copolymer with a yield of 87%.

Embodiment 2

[0042] Add 300012g of three-armed polyethylene glycol into the round bottom flask, then add 21g of L-lactide and 7g of glycolide, and then add 0.04g of zinc sulfate as a catalyst. Vacuum first, then feed nitrogen, and then vacuum again, repeat 3 times, and finally react for 24 hours under the conditions of vacuum degree of 30Pa and polymerization temperature of 140°C.

[0043] The product was dissolved in distilled water at 4°C, heated to 80°C to precipitate the copolymer and the water layer was discarded, and the operation was repeated three times to remove unreacted monomers and low-molecular water-soluble substances. The resulting copolymer was freeze-dried for 96 hours at a freeze-drying vacuum of 3 Pa and a temperature of -40°C to obtain a purified 3-arm-PEG-PLGA copolymer with a yield of 89%.

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Abstract

The invention discloses biodegradable medical temperature-sensitive hydrogel which is composed of segmented copolymers of 3-arm-PEG-PLGA, wherein the PEG is tribrachia polyethylene glycol, and the molecular weight is 400-50000; the PLGA is a copolymer of lactide and glycolide, the mass ratio of the lactide and the glycolide is 2 to 1-20 to 1, and the mass ratio of the mass sum of the lactide and the glycolide and the tribrachia polyethylene glycol is 1.2 to 1-4 to 1; the temperature-sensitive hydrogel is a solution at a low temperature and converted into gel as the temperature rises, the liquid-gel temperature at which the liquid state is converted into a gel state ranges from 15 DEG C to 35 DEG C, reversibility is achieved, and the rupture strength of the temperature-sensitive hydrogel is larger than 40 mm Hg. The invention further discloses a preparing method of the temperature-sensitive hydrogel. The technology is simple, raw materials are easy to obtain, by controlling the reaction conditions, the gel temperature range of a product can meet the human physiological temperature, the product can have high rupture resistance as well, the reversibility is achieved, the biodegradable function is achieved, no organic solvent is used, and the yield is high.

Description

technical field [0001] The invention belongs to the fields of fine chemical industry and material science, in particular to a biodegradable medical temperature-sensitive hydrogel and a preparation method thereof. Background technique [0002] Temperature-sensitive hydrogel is a new type of polymer material. In addition to excellent temperature-sensitive properties and sustained-release properties of drugs, it also has excellent properties such as safety, non-toxicity, environmental protection, and pollution-free. Wide range of applications. [0003] Polyethylene glycol-modified polylactide has unique properties such as hydrophilicity, flexibility, non-toxicity, and biodegradability. Its hydrogel is electrically neutral in that it swells in water and maintains a large amount of water without dissolving. Or ionic polymer materials, which have good biocompatibility, minimal inflammatory response, and blood coagulation, have been widely used in the fields of drug controlled rel...

Claims

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Application Information

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IPC IPC(8): C08G63/664C08G63/90C08J3/075C08L67/04A61K9/06A61K47/34A61K45/00A61P29/00A61P31/02A61P17/02
Inventor 侯昭升贾骐张浩甄文瑶战甜甜许振韩正
Owner SHANDONG NORMAL UNIV
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