Preparation method of monodisperse polymer hollow microspheres with glucose response

A technology of hollow microspheres and polymers, applied in the field of preparation of polymer hollow microspheres, which can solve the problems of low insulin loading efficiency, complicated preparation process, poor sugar responsiveness, etc.

Active Publication Date: 2015-12-16
TAIZHOU UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Phenylboronic acid and its derivatives (PBA) are a class of sugar-responsive molecules. The literature has reported a lot of drug-loading systems utilizing PBA and its derivatives to construct insulin sugar-responsive controlled release, such as microgels (MatsumotoA, IshiiT , NishidaJ, MatsumotoH, KataokaK, MiyaharaY., Angew.Chem.Int.Ed.2012, 51, 2124), nanogels (GuZ, AimettiA, WangQ, DangT, ZhangY, VeisehO, ChengH, LangerR, AndersonD., ACSNano2013, 7, 4194), micelles (Y

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Utilize the sol-gel method to prepare the silica nanoparticle with double bond of average particle diameter of 200nm, 0.5g silica is dispersed in 800mL acetonitrile, 0.5g azobisisobutyronitrile (AIBN), 4mL methyl Add ethylene glycol acrylate (EGDMA), 4mL methacrylic acid (MAA), and 12mL cinnamaldehyde into a clean 1000mL single-necked bottle, install a rectification column, a condenser tube and a receiving bottle, freeze with liquid nitrogen and vacuumize it with nitrogen , the reaction bottle was placed in an electric heating mantle and heated slowly, the reaction solution boiled within 45 minutes, and the solvent began to be evaporated, and 400mL of acetonitrile was controlled to be evaporated within 3 hours to stop the reaction. After the reaction solution is centrifuged, pour out the supernatant, centrifuge and wash, repeat several times, add 40% hydrofluoric acid to the microsphere aqueous solution, stir and react for 4 hours, remove silicon dioxide, and the product...

Embodiment 2

[0023] Preparation of silica nanoparticles with double bonds with an average particle size of 200nm by sol-gel method, 0.5gSiO 2 Disperse in 800mL acetonitrile, add 0.5gAIBN, 4mLEGDMA, 4mLMAA, and 12mL cinnamaldehyde into a clean 1000mL single-necked bottle, install a rectification column, a condenser tube and a receiving bottle, freeze with liquid nitrogen, vacuumize and ventilate the reaction bottle Slowly heat in an electric heating mantle, the reaction solution boils within 45 minutes, and the solvent begins to evaporate, and 400 mL of acetonitrile is controlled to evaporate within 3 hours to stop the reaction. After the reaction solution is centrifuged, pour out the supernatant, centrifuge and wash, repeat several times, add 40% hydrofluoric acid to the microsphere aqueous solution, stir and react for 4 hours, remove silicon dioxide, and the product is subjected to multiple ultrasonic dispersion, washing, centrifugation, Repeated several times, the obtained polymer hollow...

Embodiment 3

[0026] Utilize the sol-gel method to prepare the silica nanoparticles with double bond with average particle diameter of 200nm, 0.5g silica is dispersed in 800mL acetonitrile, 0.5gAIBN, 4mLEGDMA, 4mLMAA, 12mL cinnamaldehyde, add to clean In a 1000mL single-necked bottle, install a rectification column, a condenser tube and a receiving bottle. After the liquid nitrogen is frozen and evacuated, the reaction bottle is placed in an electric heating mantle and heated slowly. The reaction solution boils within 45 minutes and begins to evaporate the solvent. 400 mL of acetonitrile was distilled off within 3 hours to stop the reaction. After the reaction solution is centrifuged, pour out the supernatant, centrifuge and wash, repeat several times, add 40% hydrofluoric acid to the microsphere aqueous solution, stir and react for 4 hours, remove silicon dioxide, and the product is subjected to multiple ultrasonic dispersion, washing, centrifugation, Repeated several times, the obtained p...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a preparation method of monodisperse polymer hollow microspheres containing functional aldehyde groups and phenylboronic acid and having the glucose response characteristic. The polymer hollow microspheres are copolymerized by functional monoene monomers containing aldehyde groups and carboxyl groups as well as polyene hydrocarbon monomers and are modified by phenylboronic acid. In the presence of a silica template, the functional monoene monomers and the polyene hydrocarbon monomers as a crosslinking agent are copolymerized, a series of polymer microspheres with different inner diameters, different wall thicknesses and different ratio of the aldehyde groups to the carboxyl groups are prepared, the carboxyl groups and aminobenzeneboronic acid have an acylation reaction, and the polymer hollow microspheres with different phenylboronic acid modifying degrees are prepared. The preparation method has the advantages that the conditions are simple, the operation is convenient, polymer cavities are controlled easily, the glucose response range and performance of the polymer hollow microspheres are easy to adjust and the like. The prepared polymer hollow microspheres with glucose response can be applied to controllable release of insulin and has broad application prospects when serving as an insulin support and applied to diabetes treatment.

Description

technical field [0001] The invention relates to a method for preparing a sugar-responsive, monodisperse polymer hollow microsphere containing functional groups aldehyde group and phenylboronic acid. Background technique [0002] Phenylboronic acid and its derivatives (PBA) are a class of sugar-responsive molecules. The literature has reported a lot of drug-loading systems utilizing PBA and its derivatives to construct insulin sugar-responsive controlled release, such as microgels (MatsumotoA, IshiiT , NishidaJ, MatsumotoH, KataokaK, MiyaharaY., Angew.Chem.Int.Ed.2012, 51, 2124), nanogels (GuZ, AimettiA, WangQ, DangT, ZhangY, VeisehO, ChengH, LangerR, AndersonD., ACSNano2013, 7, 4194), micelles (YangH, SunX, LiuG, MaR, LiZ, AnY, ShiL., SoftMatter2013, 9, 8589), vesicles (KimH, KangYJ, KangS, KimKT., J.Am.Chem.Soc. 2012, 134, 4030), etc. However, some of these systems have complex preparation processes and are not stable enough in size, such as micelles and vesicles; or have ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C08F216/34C08F220/28C08F220/06C08F8/42
Inventor 武承林应安国侯娜陈秋萍
Owner TAIZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap