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Nystatin aqueous solution and preparation method thereof

A technology of nystatin and aqueous solution, applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive system, etc., can solve the problems of inability to remove molds and toxins, low absorption rate and utilization rate, and inability to achieve therapeutic dosage, etc. To achieve the effect of improving poultry production performance, high absorption rate and utilization rate, and relieving immunosuppression

Inactive Publication Date: 2015-12-23
淄博维希尔生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, glandular gastritis and myogastritis caused by mycotoxins are common, and the prevention and control measures can be roughly divided into two types: one is to add a mold remover to the feed, and the mold remover can only remove part of the mold. There is no removal and removal effect, and it is impossible to remove the mold and toxins in the chicken body. This method focuses on prevention, and the treatment effect is poor; the other is to mix nystatin in the feed, take the mixture orally, and at the same time cooperate with copper sulfate drinking water Intestinal cleansing treatment, glucose, vitamin C nutrient solution to increase energy and alleviate the effects of poisoning, anti-inflammatory drugs for anti-inflammatory treatment, this way of taking more types of medicines, and there are drug reactions between the medicines, so generally can not be used together, and should be taken regularly at intervals , time-consuming and labor-intensive, very inconvenient, and the number of chickens in large-scale farms is generally 100,000-200,000, and the feed is tons at a time. The mixing operation is unrealistic, and the mixing is uneven. On the contrary, they are thirsty and drink more water, so the amount of nystatin that enters the chicken body through oral administration of mixed ingredients is very little, which cannot reach the therapeutic dosage, the absorption rate and utilization rate are low, and the therapeutic effect is poor, resulting in a great waste of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] An aqueous solution of nystatin, in parts by weight, comprising the following raw materials: 40 parts of nystatin, 40 parts of propolis, 30 parts of glucose oxidase, 100 parts of cumene, 200 parts of methyl isobutyl ketone, volume fraction 100 parts of 95% ethanol.

[0024] A preparation method for an aqueous solution of nystatin, comprising the following steps:

[0025] 1) Pulverize 40 parts by weight of nystatin and 30 parts by weight of glucose oxidase, the particle size of which is 325 mesh, and store it for later use;

[0026] 2) Mix 100 parts by weight of cumene and 200 parts by weight of methyl isobutyl ketone, put them into a liquid mixing tank, and incubate at a temperature of 60°C for 30 minutes;

[0027] 3) Add the pulverized nystatin and glucose oxidase in step 1) to the mixture of cumene and methyl isobutyl ketone obtained in step 2), stir thoroughly for 30 minutes at a stirring speed of 1100 rpm, then cool to room temperature, and Place for 2h, filter to...

Embodiment 2

[0032] An aqueous solution of nystatin, in parts by weight, comprising the following raw materials: 60 parts of nystatin, 60 parts of propolis, 40 parts of glucose oxidase, 200 parts of cumene, 400 parts of methyl isobutyl ketone, volume fraction 200 parts of 95% ethanol.

[0033] A preparation method for an aqueous solution of nystatin, comprising the following steps:

[0034] 1) Pulverize 60 parts by weight of nystatin and 40 parts by weight of glucose oxidase, the particle size of which is 400 mesh, and put it aside for later use;

[0035] 2) Mix 200 parts by weight of cumene and 400 parts by weight of methyl isobutyl ketone, put them into a liquid mixing tank, and incubate at 80°C for 20 minutes;

[0036] 3) Add the pulverized nystatin and glucose oxidase in step 1) to the mixture of cumene and methyl isobutyl ketone obtained in step 2), stir thoroughly for 40 minutes at a stirring speed of 1200 rpm, then cool to room temperature, Stand still for 4h, filter to obtain the...

Embodiment 3

[0041] An aqueous solution of nystatin, in parts by weight, comprising the following raw materials: 50 parts of nystatin, 50 parts of propolis, 35 parts of glucose oxidase, 150 parts of cumene, 300 parts of methyl isobutyl ketone, volume fraction 150 parts of 95% ethanol.

[0042] A preparation method for an aqueous solution of nystatin, comprising the following steps:

[0043] 1) Grinding 50 parts by weight of nystatin and 35 parts by weight of glucose oxidase, the particle size of which is 500 mesh, and put it aside for later use;

[0044] 2) Mix 150 parts by weight of cumene and 300 parts by weight of methyl isobutyl ketone, put them into a liquid mixing tank, and incubate at a temperature of 70°C for 25 minutes;

[0045] 3) Add the pulverized nystatin and glucose oxidase in step 1) to the mixture of cumene and methyl isobutyl ketone obtained in step 2), stir thoroughly for 35 minutes at a stirring speed of 1300 rpm, then cool to room temperature, Stand still for 3h, filt...

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Abstract

The invention relates to a nystatin aqueous solution and a preparation method thereof. The nystatin aqueous solution is prepared from the raw materials in parts by weight: 40 to 60 parts of nystatin, 40 to 60 parts of propolis, 30 to 40 parts of glucose oxidase, 100 to 200 parts of isopropyl benzene, 200 to 400 parts of methylisobutylketone and 100 to 200 parts of ethyl alcohol. Compared with the prior art, the nystatin aqueous solution has the characteristics that one medicine has multiple effects, fast action can be taken, and the treating effect is obvious.

Description

technical field [0001] The invention relates to the technical field of poultry medicine, in particular to an aqueous solution of nystatin and a preparation method thereof. Background technique [0002] Mycotoxins are toxic metabolites produced by mold growth in grain or feed. Hundreds of mycotoxins have been discovered, and these toxins have different toxicity, metabolic pathways and target organs in animals. The main toxicity of mycotoxins to humans and livestock is neurological and endocrine disorders, immunosuppression, carcinogenic teratogenicity, liver and kidney damage, and reproductive disorders. Chickens are inherently sensitive to mycotoxins, and low levels of mycotoxins in the feed can cause mass mortality in the flock. [0003] At present, glandular gastritis and myogastritis caused by mycotoxins are common, and the prevention and control measures can be roughly divided into two types: one is to add a mold remover to the feed, and the mold remover can only remove...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K9/08A61P31/00A61P1/14A61P37/04A61K31/7048A61K35/644
Inventor 王东明宫翠翠孙瑞利张勇张淄博
Owner 淄博维希尔生物技术有限公司
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