Multi-responsive pNIPAAm (poly(N-isopropylacrylamide))/(mPEG-g-CMCS) (methoxy polyethylene glycol-g-carboxymethyl chitosan) aquagel

A mpeg-g-cmcs, responsive technology, applied in the field of multiple responsive pNIPAAm/hydrogel and its preparation, can solve the problems of low swelling degree of hydrogel, and achieve cheap raw materials, short operation period and simple preparation method. Effect

Inactive Publication Date: 2015-12-23
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But its disadvantages are: the resulting hydrogel has a low degree of swelling, and it shrinks completely in the temperature range after 32°C, and there is basically no temperature sensitivity

Method used

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  • Multi-responsive pNIPAAm (poly(N-isopropylacrylamide))/(mPEG-g-CMCS) (methoxy polyethylene glycol-g-carboxymethyl chitosan) aquagel
  • Multi-responsive pNIPAAm (poly(N-isopropylacrylamide))/(mPEG-g-CMCS) (methoxy polyethylene glycol-g-carboxymethyl chitosan) aquagel
  • Multi-responsive pNIPAAm (poly(N-isopropylacrylamide))/(mPEG-g-CMCS) (methoxy polyethylene glycol-g-carboxymethyl chitosan) aquagel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Dissolve 10.00gmPEG in 30mLDMSO and 2mL chloroform, and pass argon for 30min;

[0027] 2) Add 5 mL of acetic anhydride to the solution in 1), and react for 10 hours; pour the reaction solution into anhydrous ether for precipitation for 3 times, and obtain a white solid formylated mPEG;

[0028] 3) Dissolve 1.00g of CMCS and 2.77g of formylated mPEG, adjust the pH to 6.5, and pass argon for 30 minutes;

[0029] 4) 0.57gNaBH 4 Add the solution in 3) and react for 18h. Dialyzed for 3 days, freeze-dried to obtain mPEG-g-CMCS;

[0030] 5) Dissolve 4.00g NIPAAm in 50mL water;

[0031] 6) Add 0.08g BIS to the solution in 5), shake to dissolve;

[0032] 7) 0.40gmPEG-g-CMCS. Add the solution in 5) and shake to dissolve;

[0033] 8) Pass argon for 30 minutes to the solution in 7), and seal after removing oxygen;

[0034] 9) Put the solution in 8) in a refrigerator at 4°C for 1 hour, add 0.08g APS and 0.02g TEMED, and react at room temperature for 24 hours;

[0035] 10)...

Embodiment 2

[0037] 1) Dissolve 10.00gmPEG in 30mLDMSO and 2mL chloroform, and pass argon for 30min;

[0038] 2) Add 5mL of acetic anhydride to the solution in 1), and react for 10h. The reaction solution was poured into anhydrous ether for precipitation 3 times to obtain a white solid formylated mPEG;

[0039] 3) Dissolve 1.00g of CMCS and 2.77g of formylated mPEG, adjust the pH to 6.5, and pass argon for 30 minutes;

[0040] 4) 0.57gNaBH 4 Add the solution in 3) and react for 18h. Dialyzed for 3 days, freeze-dried to obtain mPEG-g-CMCS;

[0041] 5) Dissolve 4.00g NIPAAm in 50mL water;

[0042] 6) Add 0.08g BIS to the solution in 5), shake to dissolve;

[0043] 7) 0.6gmPEG-g-CMCS. Add the solution in 5) and shake to dissolve;

[0044] 8) Pass argon for 30 minutes to the solution in 7), and seal after removing oxygen;

[0045] 9) Put the solution in 8) in a refrigerator at 4°C for 1 hour, add 0.08g APS and 0.02g TEMED, and react at room temperature for 24 hours;

[0046] 10) Soak th...

Embodiment 3

[0048] 1) Dissolve 10.00gmPEG in 30mLDMSO and 2mL chloroform, and pass argon for 30min;

[0049] 2) Add 5mL of acetic anhydride to the solution in 1), and react for 10h. The reaction solution was poured into anhydrous ether for precipitation 3 times to obtain a white solid formylated mPEG;

[0050] 3) Dissolve 1.00g of CMCS and 2.77g of formylated mPEG, adjust the pH to 6.5, and pass argon for 30 minutes;

[0051] 4) 0.57gNaBH 4 Add the solution in 3) and react for 18h. Dialyzed for 3 days, freeze-dried to obtain mPEG-g-CMCS;

[0052] 5) Dissolve 4.00g NIPAAm in 50mL water;

[0053] 6) Add 0.08g BIS to the solution in 5), shake to dissolve;

[0054] 7) Add 0.8gmPEG-g-CMCS to the solution in 5), shake to dissolve;

[0055] 8) Pass argon for 30 minutes to the solution in 7), and seal after removing oxygen;

[0056] 9) Put the solution in 8) in a refrigerator at 4°C for 1 hour, add 0.08g APS and 0.02g TEMED, and react at room temperature for 24 hours;

[0057] 10) Soak th...

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Abstract

The invention discloses a multi-responsive pNIPAAm (poly(N-isopropylacrylamide)) / (mPEG-g-CMCS) (methoxy polyethylene glycol-g-carboxymethyl chitosan) aquagel and a preparation method thereof. The aquagel is prepared by the following steps: modifying mPEG with formyl group, grafting with natural polysaccharide CMCS to form mPEG-g-CMCS, and carrying out crosslinking reaction with NIPAAm (N-isopropylacrylamide). The preparation method comprises the following steps: modifying the mPEG with formyl group by using acetic anhydride, and carrying out reduction grafting on the CMCS by using NaBH4 to obtain the mPEG-g-CMCS; and dissolving the mPEG-g-CMCS, N,N'-methylene-bis-acrylamide and NIPAAm in deionized water, introducing argon to remove oxygen, carrying out sealed refrigeration at 4 DEG C for 1 hour, and adding N,N,N',N-tetramethyl ethylene diamine and ammonium persulfate at room temperature to react for 24 hours, thereby obtaining the pNIPAAm / (mPEG-g-CMCS) aquagel. The method is simple to operate, and has the advantages of cheap raw materials and wide resources. The prepared aquagel has the advantages of dual sensitivity to temperature and pH and high degree of swelling. Compared with the pure pNIPAAm, the aquagel has very high biocompatibility and wider application range.

Description

technical field [0001] The invention belongs to the field of polymer modification, in particular to a multi-responsive pNIPAAm / (mPEG-g-CMCS) hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a polymer material that uses water as the dispersion medium, has a three-dimensional network structure, can absorb a large amount of water to swell in water, and can maintain its original three-dimensional network structure after swelling. The water absorption of hydrogel is derived from -OH, -CONH-, -CONH in the structure 2 , -COOH, -SO 3 Hydrophilic groups such as H, most hydrogels can usually accommodate several times to hundreds of times their own weight in water. This water-rich colloidal structure makes its physical properties very similar to living tissue materials. Because of its excellent biomimeticity and biocompatibility, the ability to protect drugs from acid hydrolysis or enzymatic hydrolysis, and control drug release, hydrogels are wide...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L87/00C08G81/00C08B37/08C08G65/331
Inventor 程翠张秀丽夏丹丹陈景帝张其清
Owner FUZHOU UNIVERSITY
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