Moxifloxacin hydrochloride liniment and preparation method thereof

Abstract

The invention discloses moxifloxacin hydrochloride liniment and a preparation method thereof. The moxifloxacin hydrochloride liniment is used for treating respiratory tract, skin and soft tissue infection caused by sensitive bacteria. Chitosan is added to the moxifloxacin hydrochloride liniment, is deacetylation products of shellfishes, and is good in biocompatibility, film-forming property and stickiness, certain antibiosis, antiphlogosis and hemostasis functions are achieved, the chitosan is novel excellent medical pharmaceutic adjuvant, the liniment prepared from the chitosan and moxifloxacin hydrochloride can achieve partial topical application, the first pass effect of the liver and the gastrointestinal tract effect are avoided, bioavailability is improved, and the curative effect is enhanced. Oleum morrhuae is rich in vitamin A and vitamin E, and growth of granulation tissue can be promoted. Glycerinum can assist in dissolving of moxifloxacin hydrochloride, and can also increase medicine transdermal absorption. The liniment is good in adhesive force, good in spreading performance, fast in film forming and not prone to falling off, certain tearing strength is achieved, and cleaning is easy. The preparation process is simple, the content measuring result is accurate, quality is stable, use is safe and convenient, and the liniment is suitable for hospital preparations.

Description

technical field [0001] The invention relates to the field of film-coating agents of medicines, in particular to a film-coating agent of moxifloxacin hydrochloride and a preparation method thereof. Background technique [0002] Moxifloxacin hydrochloride, as the fourth-generation quinolone broad-spectrum antibacterial drug, is mainly used to treat respiratory tract, skin and soft tissue infections caused by sensitive bacteria, but adverse reactions in the digestive system may occur when it is taken orally. Currently, there are injections, tablets, capsules, gels, eye drops, ear drops and suppositories available in the domestic market, but there is no preparation of moxifloxacin hydrochloride film coating. Contents of the invention [0003] The object of the present invention is to provide a moxifloxacin hydrochloride coating agent for treating respiratory tract, skin and soft tissue infection caused by sensitive bacteria. [0004] Another object of the present invention is...

AI Technical Summary

Problems solved by technology

[0002] Moxifloxacin hydrochloride, as the fourth-generation quinolone broad-spectrum antibacterial drug, is mainly used to treat respiratory tract, skin and soft tissue infections caused by sensitive bacteria, but adverse reactions in the digestive system may occur when taken orally

At present, the dosage forms on the domestic market include injections, tablets, capsules, existing gels, eye drops, ear drops and suppositories, etc., but there is no preparation of moxifloxacin hydrochloride film coating