Preparation method of paper chip modified based on fluorescent molecular imprinting silicon dioxide nanometer microspheres

Abstract

The invention belongs to the technical field of nanometer material science and micro-fluidic chips, and relates to a preparation method of a paper chip modified based on fluorescent molecular imprinting silicon dioxide nanometer microspheres. The problem that the paper chip cannot achieve complex functional modification easily is solved. The preparation method comprises the steps that monodispersity silicon dioxide nanoparticles are prepared through a sol-gel method, and surface amidated modification is carried out on the silicon dioxide nanoparticles; fluorescent conjugated polymers having high selectivity and sensitivity for nitrobenzene are synthesized through an Suzuki reaction; the conjugated polymers are bonded through a covalent bond and crosslinked to the surfaces of the silicon dioxide nanoparticles to form the fluorescent molecular imprinting silicon dioxide nanometer microspheres; the fluorescent molecular imprinting silicon dioxide nanometer microspheres are evenly fixed to the surface of the detection area of the paper chip, and therefore the paper chip modified based on the fluorescent molecular imprinting silicon dioxide nanometer microspheres is obtained. Functional modification can be rapidly and easily carried out on the paper chip, and therefore high-sensitivity detection on micro nitrobenzene in water is achieved.

Description

technical field [0001] The invention belongs to the field of material science and engineering and microfluidic chip technology, and is a paper chip that detects nitrobenzene compounds in water by modifying the surface fluorescent molecular imprinting of silica nanoparticles and fixing them in the detection area of ​​the paper chip. Preparation. Background technique [0002] Nitrobenzene compounds, such as m-nitrotoluene, p-nitrophenol, nitrobenzene, 1-dinitrochlorobenzene and 1-trinitrotoluene, have been widely used in medicine as a class of important chemical raw materials. , pesticides, explosives, dyes, paper, textiles and other fields. The nitrobenzene in the environment mainly comes from the waste water and exhaust gas of chemical plants and dye factories, especially the sewage discharged from aniline dye factories contains a large amount of nitrobenzene. After nitrobenzene compounds invade the human body, they can cause convulsions, abdominal pain, headache, mild diz...

AI Technical Summary

Problems solved by technology

[0006] The invention belongs to the field of nanomaterial science and microfluidic chip technology, relates to a method for preparing a paper chip modified by fluorescent molecularly imprinted silica nanospheres, and solves the problem that the paper chip is difficult to carry out complex functional modification

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