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A kind of preparation method and application of Sandang total flavonoids

A technology of total flavonoids and volume concentration, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, bone diseases, etc., can solve limited, limited promotion and application of medicinal materials, and no hyperuricemia in the preparation method of total flavonoids of Santang Drugs and other problems, to achieve the effect of convenient use, low cost, simple preparation method

Inactive Publication Date: 2019-07-19
THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current basic research on Santang is still very limited, which limits the subsequent promotion and application of this medicinal material.
Modern research has few reports on the chemical components and pharmacological effects of Sandang, and there is no report on the preparation method of the total flavonoids of Sandang and its use in the preparation of drugs for the treatment of hyperuricemia

Method used

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  • A kind of preparation method and application of Sandang total flavonoids
  • A kind of preparation method and application of Sandang total flavonoids
  • A kind of preparation method and application of Sandang total flavonoids

Examples

Experimental program
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Effect test

Embodiment 1

[0017] A preparation method of total flavonoids of Sandang, comprising the following steps:

[0018] Crush Sangdang into a 60-mesh sieve powder, soak in ethanol with 8 times the weight of the powder and a volume concentration of 60% for 1.0 h, reflux extraction at 80°C for 2 times, the first time for 1.5 h, the second time for 1 h, and discard the filter residue , combine the extracts; concentrate the extracts under reduced pressure to a relative density of 1.07, add ethanol with a volume concentration of 99% to an alcohol content of 95%, let stand for 12 hours, discard the precipitate, recover the ethanol from the supernatant under reduced pressure, and concentrate to a medicinal solution The mass concentration of Sangdang crude drug is 0.4g / ml to obtain the sample solution; put the sample solution on the AB-8 type macroporous adsorption resin column, the ratio of resin to sample volume is 10:1, and the diameter-to-height ratio of the resin column is 1 : 10; first elute with ...

Embodiment 2

[0020] A preparation method of total flavonoids of Sandang, comprising the following steps:

[0021] Crush Sangdang into medicinal powder passing through a 10-mesh sieve, soak in ethanol with 6 times the weight of the medicinal powder and a volume concentration of 90% for 2.0 hours, and reflux extraction at 60°C for 4 times, the first time for 2 hours, the second time for 1 hour, and the third time for 1.5 h, the fourth time 2h, discard the filter residue, and combine the extract; concentrate the extract under reduced pressure to a relative density of 1.05, add ethanol with a volume concentration of 99% to an alcohol content of 70%, let stand for 8h, discard the precipitate, and supernatant Liquid decompression reclaims ethanol, concentrates to the mass concentration of San Dang crude drug in the medicinal liquid and is 0.2g / ml, obtains the sample liquid; AB-8 type macroporous adsorption resin column is put on the sample liquid, and the ratio of resin and sample amount volume i...

Embodiment 3

[0023] A preparation method of total flavonoids of Sandang, comprising the following steps:

[0024] Crush Sangdang into medicinal powder passing through an 80-mesh sieve, soak in ethanol with 10 times the weight of the medicinal powder and a volume concentration of 50% for 0.5h, and reflux extraction at 85°C for 3 times, the first time for 3h, the second time for 2h, and the third time for 1h , discard the filter residue, and combine the extracts; concentrate the extracts under reduced pressure to a relative density of 1.15, add ethanol with a volume concentration of 99% to an alcohol content of 80%, let stand for 24 hours, discard the precipitate, and recover the ethanol from the supernatant under reduced pressure. Concentrate until the mass concentration of mulberry crude drug in the medicinal liquid is 0.5g / ml to obtain the sample liquid; put the sample liquid on the AB-8 type macroporous adsorption resin column, the ratio of the resin to the sample volume is 10:1, and the ...

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Abstract

The invention discloses a preparation method and application of Sangdang total flavone. The preparation method includes: smashing Sangdang, using alcohol for soaking, and performing backflow extraction; concentrating extract, adding alcohol for standing, obtaining supernate, depressurizing to recycle alcohol, and concentrating; loading concentrate, and using water, alcohol of 5-30% in volume concentration and alcohol of 40-80% of volume concentration for elution respectively; taking eluate of the last time, depressurizing to recycle alcohol, and concentrating and drying to obtain Sangdang total flavone. Sangdang is used as a raw material for the first time to prepare Sangdang total flavone, and the raw material is rich in source, low in cost, convenient to use, quick in action, little in suffering of a patient, nonresistant to drug, small in toxic and side effect and high in safety coefficient. The preparation method is simple and convenient to operate, Sangdang total flavone prepared by the method can be effectively used for treatment of hyperuricemia, and studying and popularization of Sangdang are promoted powerfully.

Description

technical field [0001] The invention relates to a preparation method of the total flavonoids of mulberry and also designs the application of the total flavonoids of mulberry, which belongs to the technical field of traditional Chinese medicine. Background technique [0002] Hyperuricemia is a disease in which blood uric acid is increased due to purine metabolism disorder and / or uric acid excretion disorder, and extracellular fluid urate is supersaturated. Hyperuricemia can be clearly diagnosed when blood uric acid exceeds 416 μmol / L. Ultra-high protein diet is an important cause of purine metabolism disorder, excessive intake of sugar, fat, protein and heavy drinking have important relationship with the increase of the prevalence. When the blood uric acid concentration is too high, uric acid is deposited in the joints and subcutaneous tissue in the form of sodium salt, leading to gout. Therefore, about 5% to 12% of patients with hyperuricemia will develop gout. Gout can no...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/77A61P19/06
Inventor 张峰梁瑞峰宋献美吴晓东
Owner THE CHINESE TRADITIONAL HERB MEDICINE RES INST HENAN PROV