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Porous biological support slurry, three-dimensional porous biological support and preparation method of support

A bio-scaffold, three-dimensional porous technology, applied in the field of medical materials, can solve the problems that porous bio-scaffold materials cannot be effectively extruded, cannot maintain line shape and span, and is time-consuming and labor-intensive in molding, and achieves flexible shape and size. , complete structure, good connection effect

Active Publication Date: 2016-01-13
SHENZHEN UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, to provide a porous bio-scaffold slurry for direct writing molding, to solve the problem that the existing porous bio-scaffold material is only suitable for compression molding or cannot be effectively extruded by printing or Technical issue with being extruded and not maintaining line shape and span
[0007] Another object of the present invention is to overcome the above-mentioned deficiencies of the prior art, and provide a three-dimensional porous bio-scaffold and its preparation method to solve the technical problems of time-consuming and labor-intensive molding of the existing porous bio-scaffold material and low production efficiency

Method used

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  • Porous biological support slurry, three-dimensional porous biological support and preparation method of support

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[0034] In yet another aspect of the embodiments of the present invention, the embodiments of the present invention also provide a method for preparing the above-mentioned three-dimensional porous bioscaffold. In one embodiment, the preparation method of the three-dimensional porous bioscaffold comprises the following steps:

[0035] Step S01: Convert the three-dimensional porous bioscaffold design drawing into a code language recognizable by the computer, and write the slurry of the porous bioscaffold in the embodiment of the present invention described above along the path specified by the computer according to the code language Forming technology extrudes layer by layer to form a green body with multi-layer ordered three-dimensional porous network structure;

[0036] Step S02: The green body is dried and sintered to remove organic components in the green body.

[0037] Specifically, in the above step S01, the three-dimensional porous bioscaffold design is one of the bases o...

Embodiment 1

[0047] This embodiment is a porous bioscaffold slurry for direct writing. The porous biological support slurry (ceramic slurry) includes a mixture of hydroxyapatite powder and zirconia powder, ammonium citrate dispersant and PVA binder, and the content of hydroxyapatite powder is 1% of the mixed powder. 50%wt, the particle size of hydroxyapatite powder is about 40-100nm, and the particle size of zirconia powder is about 100-200nm; the content of the ammonium citrate dispersant in the porous biological support slurry is 0.5%wt , the content of the PVA binder in the porous biological scaffold slurry is 0.5%wt.

[0048] The solid phase content of the bioceramic scaffold slurry is 55%wt, and the solvent of the slurry is deionized water.

[0049] In Example 1, before the preparation of the porous bioscaffold slurry, the mixture of hydroxyapatite powder and zirconia powder was ball milled with alcohol as a grinding aid, placed in a constant temperature drying oven after 24 hours, a...

Embodiment 2

[0051] This embodiment is a porous bioscaffold slurry (ceramic slurry) for direct writing. The ceramic slurry includes a mixture of hydroxyapatite powder and zirconia powder, a methylcellulose dispersant and a PVB binder; the content of the hydroxyapatite powder is 60% of the mixed powder, and the hydroxyapatite The particle size of the powder is about 100-150nm, and the particle size of the zirconia powder is about 200-300nm; the content of the methylcellulose dispersant is 1%wt, and the content of the PVB binder is 1%wt.

[0052] The solid content of the bioceramic scaffold slurry is 65%wt

[0053] The solvent of the slurry is deionized water.

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Abstract

The invention discloses a porous biological support slurry, a three-dimensional porous biological support and a preparation method of the support. The porous biological support slurry comprises the following compositions: hydroxyapatite powder, zirconium oxide powder, a dispersant, a slurry stabilizing agent and a solvent. The three-dimensional porous biological support is formed by directly employing a direct-writing molding technology for processing the porous biological support slurry. The preparation method for the three-dimensional porous biological support comprises steps of preparing a direct-writing molded body, performing heat treatment on the body and the like. The porous biological support slurry possesses viscoelasticity response capable of being regulated and controlled and the shear thinning rheology characteristic, and therefore the slurry can be smoothly extruded and printed. The interior of the three-dimensional porous biological support shows periodic arrangement, and the whole three-dimensional porous biological support is a multi-layer cancellate stereo structure, the upper layer and the lower layer at the junction of the grid are in good connection, no accumulation collapse exist, the structure is complete, and the preparation method of the support enables a printed line to be capable of maintaining the line shape and a certain span even without any support, and is high in efficiency.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a porous bioscaffold slurry used for direct writing molding, a three-dimensional porous bioscaffold formed by direct writing using the porous bioscaffold slurry and a preparation method thereof. Background technique [0002] Human bone tissue defect is a common disease, which may be caused by factors such as skin trauma, internal infection, and tumor surgery. Bone tissue engineering is a subject that uses the basic principles and technologies of life science and engineering to artificially simulate bone structure, construct a three-dimensional porous biocompatible scaffold material, and stimulate and induce cell proliferation and osteogenesis on the scaffold. At present, hydroxyapatite (HAp) is the most widely used material in inorganic bioceramics, its composition and physical and chemical properties are similar to the inorganic components of human bones, i...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/50A61L27/12A61L27/04
Inventor 李亚运熊信柏曾燮榕马俊
Owner SHENZHEN UNIV
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