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Mono-ammonium glycyrrhizinate and preparing method thereof

A technology of glycyrrhizic acid monoammonium salt and glycyrrhizic acid precipitant, applied in the field of glycyrrhizic acid monoammonium salt and preparation thereof, can solve the problems of high production cost and high impurity content of glycyrrhizic acid monoammonium salt, achieve good quality and reduce production cost , the effect of low content

Active Publication Date: 2016-01-13
新疆天山制药工业有限公司
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  • Description
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Problems solved by technology

[0003] The present invention provides a monoammonium glycyrrhizinate salt and a preparation method thereof, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem of existing monoammonium glycyrrhizinate The salt production process has the problems of high production cost and high impurity content of monoammonium glycyrrhizinate

Method used

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  • Mono-ammonium glycyrrhizinate and preparing method thereof

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Effect test

Embodiment 1

[0019] Example 1, such as figure 1 As shown, the glycyrrhizic acid monoammonium salt is obtained according to the following preparation method: in the first step, the glycyrrhizic acid precipitate is weighed by 200kg to 500kg, and the glycyrrhizic acid precipitate is added to the weighed glycyrrhizic acid precipitate 8 times to 12 times. Double the mass of the secondary extract and mix evenly, extract at a temperature of 30°C to 60°C for 1h to 4h, stand still for 4h to 8h after extraction, and obtain the primary extract and primary residue after filtration; the second step, in the primary Add pure water to the extract and mix evenly to obtain a mixed solution. After the pure water is added, the mass percentage of water in the mixed solution is 10% to 15%, and then the pH value of the mixed solution is adjusted to 4 to 5 to obtain a neutralized solution. The third step is to add 10kg to 100kg of activated carbon to the neutralizing solution, stir and decolorize at a temperat...

Embodiment 2

[0020] Example 2, such as figure 1 As shown, the glycyrrhizic acid monoammonium salt is obtained by the following preparation method: the first step, weigh the glycyrrhizic acid precipitate by 200kg or 500kg, add the glycyrrhizic acid precipitate 8 times or 12 twice the mass of the secondary extract and mix evenly, extract at a temperature of 30°C or 60°C for 1h or 4h, stand still for 4h to 8h after extraction, and obtain the primary extract and primary residue after filtration; the second step, in the primary Add pure water to the extract and mix evenly to obtain a mixed solution. After the pure water is added, the mass percentage of water in the mixed solution is 10% or 15%, and then the pH value of the mixed solution is adjusted to 4 or 5 to obtain a neutralized solution. ; The third step is to add 10kg or 100kg of activated carbon to the neutralizing solution, stir and decolorize at a temperature of 65°C or 75°C for 30min or 60min, and filter while it is hot to obtain w...

Embodiment 3

[0021] Embodiment 3, as the optimization of above-mentioned embodiment, secondary extracting solution obtains by following method when starting up: add the ethanol aqueous solution of 8 times to 12 times of quality of glycyrrhizic acid precipitation in glycyrrhizic acid precipitation, extraction temperature is 30 ℃ to 60 ℃, the extraction time is 1h to 4h, after extraction, let it stand for 4h to 8h, and obtain the primary filtrate and the primary residue after filtration, add the ethanol aqueous solution with 8 times to 12 times the mass of the primary residue to the primary residue, at a temperature of Extract at 30°C to 60°C for 1h to 4h, stand still for 4h to 8h after extraction, and obtain the secondary extract after filtering. The secondary extraction solution is used as the solvent for the next extraction.

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Abstract

The invention relates to the technical field of mono-ammonium glycyrrhizinate, in particular to mono-ammonium glycyrrhizinate and a preparing method thereof. The preparing method comprises the following steps that firstly, a secondary extracting solution is added into glycyrrhiza acidification precipitate for extraction, and a primary extracting solution and primary residues are obtained through filtering after extraction; secondly, pure water is added in the primary extracting solution to adjust the water content of a mixed solution, and then the PH value of the mixed solution is adjusted; thirdly, active carbon is added into a neutralizing solution for decoloration, and a first mother solution and coarse mono-ammonium glycyrrhizinate are obtained through crystallization after decoloration; fourthly, ethanol water and active carbon are added into the coarse mono-ammonium glycyrrhizinate for decoloration, and a second mother solution and the mono-ammonium glycyrrhizinate are obtained through crystallization after decoloration. Compared with an existing technology, by means of the preparing method, the production cost is greatly reduced, and resources are effectively utilized; meanwhile, compared with mono-ammonium glycyrrhizinate obtained through the existing technology, the prepared mono-ammonium glycyrrhizinate is low in content of impurities A, lighter in color and better in quality.

Description

technical field [0001] The invention relates to the technical field of monoammonium glycyrrhizinate, and relates to a monoammonium glycyrrhizinate and a preparation method thereof. Background technique [0002] Xinjiang is the main production area of ​​licorice, and its output accounts for about 80% of the country. The raw materials of licorice products mainly come from licorice Glycyrrhizauralensin Fisch. , licorice Glycyrrhiza glabra L. and licorice Glycyrrhizainfiata Bat. . At present, licorice is mainly used to produce licorice paste, licorice extract powder, licorice sweetener, glycyrrhizinate, etc. The main component of monoammonium glycyrrhizinate is glycyrrhizic acid, which has the functions of protecting the liver and detoxifying, anti-inflammation, anti-virus, anti-tumor and immune regulation. Chronic hepatitis, bronchitis and peptic ulcer, etc. Glycyrrhizic acid has two configurations, namely 18β-glycyrrhizinic acid (18β, 20β-glycyrrhizinic acid, 18β-Gly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/00C07H1/06
Inventor 苗现义范晓雯廖菁牛学军
Owner 新疆天山制药工业有限公司
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