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Superoxide dismutase microcapsule powder and preparation method thereof

A technology of dismutase microcapsule powder and superoxide, applied in cosmetic preparations, pharmaceutical formulations, dressing preparations, etc., can solve problems such as product solution inactivation failure, light sensitivity, and accelerated SOD inactivation, and achieve improved Bioavailability, delayed release, reduced irritation and immunogenicity effects

Inactive Publication Date: 2016-02-03
珠海雅莎生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the current technology are as follows: (1) sensitive to oxygen and must be stored under vacuum; (2) sensitive to light, which can accelerate the inactivation of SOD; (3) must be stored at low temperature to ensure the effective activity of the product; ( 4) SOD freeze-dried powder, after being formulated into a liquid product, the product solution will soon be inactivated and invalid

Method used

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  • Superoxide dismutase microcapsule powder and preparation method thereof
  • Superoxide dismutase microcapsule powder and preparation method thereof
  • Superoxide dismutase microcapsule powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Preparation of SOD microcapsule dry powder

[0032] 1: Dissolve 7g HP-β-CD in 10g purified water to form a saturated solution. Then take 1.4g of SOD powder, dissolve it with a small amount of purified water, add it to HP-β-CD saturated solution under stirring, and stir evenly. Place it at 4°C and continue stirring for 4 hours. Add 4g of lactose, stir evenly, freeze-dry to obtain SOD microcapsule dry powder.

[0033] 2: Dissolve 7g of HP-β-CD in 10g of purified water to form a saturated solution. Then take 7g of SOD powder, dissolve it with a small amount of purified water, add it to HP-β-CD saturated solution under stirring, and stir evenly. Place it at 4°C and continue stirring for 4 hours. Add 8g of trehalose, stir evenly, freeze-dry to obtain SOD microcapsule dry powder.

[0034] Note: The dosage of HP-β-CD is selected according to the type of its substituent. The specific dosage is subject to the saturation of the solution. The solubility of the three type...

Embodiment 2

[0035] Example 2: Comparison and verification of the activity of SOD microcapsule dry powder

[0036] The inventors used the pyrogallol autooxidation method to study the inhibitory effect of pyrogallol autooxidation before and after the action of superoxide dismutase and HP-β-CD and the stability of SOD after inclusion. The data can prove: 1. The activity of SOD after inclusion is slightly higher than that of uninclusion. 2: After inclusion, SOD can be stored at room temperature for two years.

[0037] The inventors added the SOD powder before and after the inclusion to the pyrogallol auto-oxidation system, and calculated the activity of the SOD powder through the change rate of the absorbance of the pyrogallol system at a wavelength of 325nm. The detection method adopts the determination of superoxide dismutase (SOD) activity in GB / T5009.171-2003 health food (the first method), and the sample components are as follows:

[0038]

[0039] SOD sample solution: SOD powder before inclu...

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Abstract

The invention discloses superoxide dismutase microcapsule powder and a preparation method thereof. The superoxide dismutase microcapsule powder is prepared from, by weight, 15-35 parts of hydroxypropyl-beta-cyclodextrin, 3-35 parts of superoxide dismutase and 20-40 parts of lactose or mycose. The superoxide dismutase is added into a hydroxypropyl-beta-cyclodextrin saturated solution for even mixing, wherein the weight ratio of the superoxide dismutase to the hydroxypropyl-beta-cyclodextrin is 1:(0.2-1), then the lactose or mycose is added as a protective agent, even mixing and freeze-drying are carried out, and finally the superoxide dismutase microcapsule powder is obtained. The SOD activity and stability of the superoxide dismutase microcapsule powder are obviously improved, and therefore the bioavailability of the superoxide dismutase microcapsule powder is increased.

Description

Technical field [0001] The invention relates to a superoxide dismutase microcapsule powder and a preparation method thereof, in particular to the use of microcapsule technology to increase the bioavailability of superoxide dismutase in the skin, etc., belonging to the fields of medical beauty, medicine, and cosmetics . Background technique [0002] Superoxide Dismutase Orgotein (Superoxide Dismutase, SOD), is a kind of metal enzyme, containing two ions of copper and zinc. In biology, SOD catalyzes the transformation of superoxide anions related to antibodies into hydrogen peroxide, which is then decomposed by hydrogen peroxide to protect the body from the effects of superoxide anions. It is a new type of antioxidant enzyme. [0003] Superoxide Dismutase (Superoxide Dismutase referred to as SOD) is a new type of enzyme preparation. It is widely distributed in the biological world, almost from animals to plants, and even from humans to single-celled organisms. SOD is regarded as t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K38/44A61P39/06A61K8/66A61K8/73A61Q19/08
Inventor 钱捷豪陆贵平谢伟王刚平钟小凡黄子杰
Owner 珠海雅莎生物科技股份有限公司
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