Antineoplastic traditional Chinese medicinal composition and application thereof
A composition, anti-tumor technology, applied in the field of medicine, can solve the problems of death, toxic hepatitis, restriction, etc.
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Embodiment 1
[0035] Example 1 (Ethanol Extract of Fructus Scutellariae Scutellariae, Alcohol Extract of Scutellaria Scutellariae, Alcohol Extract of Scutellaria Scutellariae and Alcohol Extract of Scutellaria Scutellaria Scutellariae Alcohol Extract Compatibility on Mouse Sarcoma S180 Solid Tumor)
[0036] The present invention first investigates the effect of the combination of ethanol extract (ET) and ethanol extract (SE) of Scutellaria sinensis on mouse sarcoma S180 solid tumor.
[0037] 1.1 Experimental materials
[0038] 1.1.1 Test animals
[0039] ICR mice, ♂, weighing 18-22 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: SCXK (Shanghai 2007-0005). The mice were reared at a temperature of (22±1)°C, a relative humidity of (65±10)%, and lighting time of 12 hours per day.
[0040] 1.1.2 Test drug and its preparation
[0041] Xanthophyllum ethanol extract (ET): Weigh 4000 g of Xanthophyllum coarse powder, add 10 times the volume of 80% eth...
Embodiment 2
[0067] Example 2 (Studies on the Antitumor Effects of Different Extracts of Xanthophyllum and Scutellaria Scutellariae)
[0068] After confirming that the composition of Scutellaria barbatae has strong anti-S180 solid tumor effect, the present invention further investigated the anti-tumor effect of other extracts of Scutellaria barbata and Scutellaria barbata in vivo.
[0069] 2.1 Experimental materials
[0070] 2.1.1 Test animals (same as 1.1.1 of Example 1)
[0071] 2.1.2 Test drug and its preparation
[0072] Suspension of whole powder of Xanthophyllum: 36g of Xanthophyllum, pulverized, passed through a 150-mesh sieve, and suspended in 180mL of distilled water.
[0073] Scutellaria barbata whole powder suspension: 36g of Scutellaria barbata, crushed, passed through a 150 mesh sieve, and suspended in 180mL of distilled water.
[0074] Aqueous extract of Xanthogonia chinensis: add 10 times the amount of water to 36 g of Xanthogonia chinensis, reflux extraction 3 times, 3 h...
Embodiment 3
[0108] Example 3 (Chinese medicine composition and its active ingredient in vivo anticancer activity research)
[0109] Through whole animal experiments, it is found that the Chinese medicine composition of the present invention has an anti-tumor effect, and the inventor further investigated the anti-cancer activity of the Chinese medicine composition of the invention and its active ingredients through in vitro experiments. Preliminary experiments have found that Dioscoreabulbifera B is the main antitumor active ingredient in Dioscorea bulifera L . rhizome in vivo. Fitoterapia 83, 388-394.). Baicalin is the main active ingredient of Scutellaria barbata, and it is also the index component of Scutellaria barbata in the Chinese Pharmacopoeia. Next, we observed the inhibitory activity of the combined use of scutellarin B and scutellarin on tumor growth.
[0110] 3.1 Experimental materials
[0111] 3.1.1 Test animals (same as 1.1.1 of Example 1)
[0112] 3.1.2 Test drugs
[01...
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