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Antineoplastic traditional Chinese medicinal composition and application thereof

A composition, anti-tumor technology, applied in the field of medicine, can solve the problems of death, toxic hepatitis, restriction, etc.

Inactive Publication Date: 2016-02-17
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been reported that xanthophyll can cause toxic hepatitis and even death in clinical use, which greatly limits its good clinical efficacy.

Method used

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  • Antineoplastic traditional Chinese medicinal composition and application thereof
  • Antineoplastic traditional Chinese medicinal composition and application thereof
  • Antineoplastic traditional Chinese medicinal composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 (Ethanol Extract of Fructus Scutellariae Scutellariae, Alcohol Extract of Scutellaria Scutellariae, Alcohol Extract of Scutellaria Scutellariae and Alcohol Extract of Scutellaria Scutellaria Scutellariae Alcohol Extract Compatibility on Mouse Sarcoma S180 Solid Tumor)

[0036] The present invention first investigates the effect of the combination of ethanol extract (ET) and ethanol extract (SE) of Scutellaria sinensis on mouse sarcoma S180 solid tumor.

[0037] 1.1 Experimental materials

[0038] 1.1.1 Test animals

[0039] ICR mice, ♂, weighing 18-22 g, were purchased from Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: SCXK (Shanghai 2007-0005). The mice were reared at a temperature of (22±1)°C, a relative humidity of (65±10)%, and lighting time of 12 hours per day.

[0040] 1.1.2 Test drug and its preparation

[0041] Xanthophyllum ethanol extract (ET): Weigh 4000 g of Xanthophyllum coarse powder, add 10 times the volume of 80% eth...

Embodiment 2

[0067] Example 2 (Studies on the Antitumor Effects of Different Extracts of Xanthophyllum and Scutellaria Scutellariae)

[0068] After confirming that the composition of Scutellaria barbatae has strong anti-S180 solid tumor effect, the present invention further investigated the anti-tumor effect of other extracts of Scutellaria barbata and Scutellaria barbata in vivo.

[0069] 2.1 Experimental materials

[0070] 2.1.1 Test animals (same as 1.1.1 of Example 1)

[0071] 2.1.2 Test drug and its preparation

[0072] Suspension of whole powder of Xanthophyllum: 36g of Xanthophyllum, pulverized, passed through a 150-mesh sieve, and suspended in 180mL of distilled water.

[0073] Scutellaria barbata whole powder suspension: 36g of Scutellaria barbata, crushed, passed through a 150 mesh sieve, and suspended in 180mL of distilled water.

[0074] Aqueous extract of Xanthogonia chinensis: add 10 times the amount of water to 36 g of Xanthogonia chinensis, reflux extraction 3 times, 3 h...

Embodiment 3

[0108] Example 3 (Chinese medicine composition and its active ingredient in vivo anticancer activity research)

[0109] Through whole animal experiments, it is found that the Chinese medicine composition of the present invention has an anti-tumor effect, and the inventor further investigated the anti-cancer activity of the Chinese medicine composition of the invention and its active ingredients through in vitro experiments. Preliminary experiments have found that Dioscoreabulbifera B is the main antitumor active ingredient in Dioscorea bulifera L . rhizome in vivo. Fitoterapia 83, 388-394.). Baicalin is the main active ingredient of Scutellaria barbata, and it is also the index component of Scutellaria barbata in the Chinese Pharmacopoeia. Next, we observed the inhibitory activity of the combined use of scutellarin B and scutellarin on tumor growth.

[0110] 3.1 Experimental materials

[0111] 3.1.1 Test animals (same as 1.1.1 of Example 1)

[0112] 3.1.2 Test drugs

[01...

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Abstract

The invention relates to the field of medicine, and in particular relates to an antineoplastic traditional Chinese medicinal composition. The traditional Chinese medicinal composition is prepared from the following medicinal raw materials in percentage by weight: 10-70% of airpotato yam rhizome and 30-90% of sculellaria barbata; and the traditional Chinese medicinal composition is a whole-powder suspension of the airpotato yam rhizome and the sculellaria barbata, or the traditional Chinese medicinal composition is an ethanol extract with concentration being 20-80%, an ethyl acetate extract, an acetone extract or a gasoline extract. The invention also relates to application of a sculellaria barbata extract and a traditional Chinese medicinal composition of the sculellaria barbata extract, wherein the traditional Chinese medicinal composition consists of the following ingredients: an ethanol extract of airpotato yam rhizome with concentration being 20-80% and an ethanol extract of sculellaria barbata with concentration being 20-80% at a weight ratio of (1-2) to (2-1). The invention also relates to application of scutellarin and a pharmaceutical composition of the scutellarin, wherein the traditional Chinese medicinal composition consists of the following ingredients: diosbulbin B and scutellarin at a weight ratio of (1-1) to (1-2). The pharmaceutical composition can be used for preventing and treating various cancers such as pancreatic cancer, breast cancer, lung cancer, colon cancer and the like.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an anti-tumor traditional Chinese medicine composition and its medical application. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health and life. In the treatment of cancer, although the traditional radiotherapy and chemotherapy have made great progress, because it kills cancer cells, it also produces different degrees of toxic side effects on the human body, mainly bone marrow suppression and low immune function. Cause leukopenia, etc., sometimes even have to interrupt treatment, which also limits the efficacy of drugs. In order to overcome a series of ills caused by traditional radiotherapy and chemotherapy, pharmaceutical workers have been exploring continuously in recent years, and the application of herbal medicines to prevent and treat cancer has become a hot research field [0003] Huangyaozi is the dry tuber of Dioscorea bulbife...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A23L1/29A61K31/7048A61P35/00A61P35/02A61K31/365
Inventor 季莉莉王峥涛陆宾盛雨辰杨睿郑智勇
Owner SHANGHAI UNIV OF T C M
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