The invention discloses an information collecting and monitoring system and an information collecting and monitoring method of a clean operating room. The information collecting and monitoring system of the clean operating room comprises a plurality of information collecting and monitoring devices, a plurality of purifying air conditioner control devices, a nurse station main server, GPRS DTU (general packet radio service data transfer unit) wireless network transmission equipment connected with the nurse station main server, and a remote monitoring and diagnosing host connected with an Internet network and having a fixed IP (internal protocol) address. The information collecting and monitoring method of the clean operating room comprises the following steps: 1, field data collection; 2, pretreatment of data wireless transmission; 3, the data wireless transmission: namely, the GPRS DTU wireless network transmission equipment transfers data to the remote monitoring and diagnosing host through a GPRS network and the Internet network; and 4, field data remote motoring and diagnosis. The information collecting and monitoring system and the information collecting and monitoring method of the clean operating room have reasonable designs, are simple and convenient to operate, and further, have good usage effects and high practical value, and the problems that a conventional information collecting and monitoring system of the clean operating room has low efficiency, low communication speed, a complicated protocol and the like can be effectively solved.