Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cockroach glucoside and medicine composition thereof and application of cockroach glucoside in pharmaceuticals and health-care products

The technology of a cockroach glycoside and a composition is applied in the application field of preparing medicines or health care products for treating ulcers and burns, and can solve the problems such as no compounds that have not been seen.

Active Publication Date: 2016-03-30
SICHUAN GOODDOCTOR PANXI PHARMA
View PDF4 Cites 14 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no relevant reports on the compounds involved in the present invention and their effects on promoting collagen production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cockroach glucoside and medicine composition thereof and application of cockroach glucoside in pharmaceuticals and health-care products
  • Cockroach glucoside and medicine composition thereof and application of cockroach glucoside in pharmaceuticals and health-care products
  • Cockroach glucoside and medicine composition thereof and application of cockroach glucoside in pharmaceuticals and health-care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Separation and purification of compound cockroach glycosides A-C: Periplaneta americana (Periplaneta americana) 20kg, pulverized, soaked and extracted with 95% ethanol at room temperature (2 times × 100L × 1 week), combined the extracts and recovered the solvent under reduced pressure to obtain a crude extract. The crude extract was suspended in an appropriate amount of water, then extracted three times with an equal volume of petroleum ether, ethyl acetate, and n-butanol, and the extracts were combined and concentrated under reduced pressure to obtain the corresponding extracts. Ethyl acetate extract (320g) was subjected to silica gel column chromatography (silica gel 200-300 mesh, 3kg), chloroform-methanol system gradient elution (100:0, 99:1, 98:2, 97:3, 96:4 , 95:5, 94:6, 93:7, 92:8, 90:10, 85:15, 80:20, 60:30), each solvent gradient is 1.5 times the column volume, according to each 500mL collection) 7 combined fractions were obtained. Component 6 (20.2g) was subje...

Embodiment 2

[0028] Any one in embodiment 2 compound A (1), B (2), C (3), will prepare 0.5% carbomer 940 solution, 5% sodium carboxymethyl cellulose solution and 0.2% poly Sodium acrylate solution, make it fully swell to make glue; weigh an appropriate amount of polyvinyl alcohol, add a small amount of water, and heat to 70°C to dissolve; add glue and glycerin to it, and stir at 50°C for about 30 minutes.

[0029] Crush, sieve, mix, heat and soften, add the main ingredient to mix to make ointment, then warm and soften, apply on the backing, add pads and cut to make balm and medicine.

Embodiment 3

[0031] Any one of the compounds A(1), B(2) and C(3) of Example 1 is mixed with fusion sealing according to the conventional method to obtain the powder injection.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides compound cockroach glucosides A to C and a drug composition thereof and their application in preparation of pharmaceuticals and health-care products for treating ulcers and burns and scalds. Ulcers and burns are fairly common, and American cockroaches clinically used for various ulcers and burns have a good effect. Three dihydrogen isocoumarin glucosides are separated and identified and are named as the cockroach glucosides A, B and C, and all the cockroach glucosides can promote dermal fibroblast collagen secretion of human and improve the treatment effect on the collagen secretion lack diseases, such as all kinds of ulcers, burns and scalds.

Description

Technical field: [0001] The invention belongs to the field of pharmaceutical technology and health care products, and in particular relates to compounds cockroach glycosides A-C and pharmaceutical compositions thereof, and their application in preparing medicines or health care products for treating ulcers and burns. Background technique: [0002] Ulcer is a defect or ulceration of skin or mucous membrane surface tissue, and its surface is often covered with pus, necrotic tissue or scab, and scars are left after healing. There are many causes of ulcers, which can be caused by infection, trauma, nodules or tumor ulceration. They are often combined with chronic infection and may not heal for a long time, such as gastric ulcer, duodenal ulcer, oral ulcer, diabetic foot disease, etc. Skin wounds such as burns and scalds are common accidental injuries in life. Previous studies have shown that the difficulty of healing ulcers and burns is related to the reduction or insufficient ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A23L1/29A61P17/02A61K35/64
Inventor 程永现耿福能杨勇勋罗奇马秀英
Owner SICHUAN GOODDOCTOR PANXI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com