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Celery seed micro-pill and preparation method thereof

A technology of celery seed and celery seed extract, which is applied in the field of medicine and food, and achieves the effect of high bioavailability and rapid onset of action

Inactive Publication Date: 2016-03-30
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, celery seed products are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above dosage forms is long Disintegrate at a certain point in the body, which has certain irritation to the gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take the following ingredients for the recipe

[0029] Celery Seed Extract 10g

[0030] Microcrystalline cellulose 82g

[0031] Hydroxypropyl Methyl Cellulose 4g

[0032] Prepare pellet formulations as follows:

[0033] (1) Take the amount of celery seed in the above formula, add microcrystalline cellulose, crush it to a micronized level with a ball mill, and mix well;

[0034] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0035] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0037] Take the following ingredients for the recipe

[0038] Celery Seed Extract 15g

[0039] Starch 85g

[0040] Polyvinylpyrrolidone 5g

[0041] Prepare pellet formulations as follows:

[0042] (1) Take the amount of celery seed in the above formula, add starch, pulverize to micronized level with a ball mill, and mix well;

[0043] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0044] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0046] Take the following ingredients for the recipe

[0047] Celery Seed Extract 8g

[0048] Sucrose 49g

[0049] Starch 34g

[0050] Polyvinylpyrrolidone 4g

[0051] Prepare pellet formulations as follows:

[0052] (1) Take the amount of celery seed in the above formula, add sucrose and starch, pulverize it to a micronized level with a ball mill, and mix well;

[0053] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0054] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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PUM

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Abstract

The invention provides a celery seed extract micro-pill preparation prepared from a celery seed extract and medicinal auxiliary materials, and is characterized in that the medicinal auxiliary materials comprise an excipient and an adhesive; in the micro-pill preparation, the weight percentage of celery seeds is 10-30%, the weight percentage of the excipient is 65-85%, and the weight percentage of the adhesive is 1-5%. The micro-pill preparation has the advantages of high dissolution rate, and high bioavailability; and a preparing method is simple, convenient, and easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a celery seed pellet and a preparation method thereof. Background technique: [0002] At present, celery seed products are widely recognized by consumers, and they are basically ordinary tablets and capsules, but the disintegration time of the above-mentioned dosage forms is long; disintegrating at a certain point in the body has harmful effects on the gastric mucosa. Certain irritation; low bioavailability and other disadvantages. Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable release in the body and high bioavailability, so as to better meet the needs of the general public. consumer needs. [0003] Pharmaceutical excipients such as excipients, binders, porogens, disintegrants, and plasticizers are gener...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61K9/16A61K9/20A61K9/48A23L1/29A23P1/04
Inventor 魏洪君
Owner JF PHARMALAND TECH DEV