Preparation method of covered endovascular stent-graft
A technology of vascular stent and film covering, which is applied in the field of preparation of covered vascular stent, can solve problems such as uneven film formation, and achieve the effects of simple operation, cost saving, good mechanical properties and biological properties
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preparation example Construction
[0017] The invention provides a method for preparing a covered vascular stent, the preparation method comprising: (1) designing and processing a core according to the vessel structure of the vascular stent to be implanted; (2) processing the first layer of stent coating on the core; (3) set the stent skeleton on the core that is processed with the first layer of stent coating; (4) process the second layer on the core that is set with the stent skeleton and processed with the first layer of stent coating Two layers of coating, and the second layer of stent coating is combined with the first layer of stent coating, so that the stent skeleton is at least partially covered in the coating; wherein, processing the first layer of stent coating When filming and / or processing the second layer of stent coating, polyvinylidene fluoride resin solution is used for film forming treatment.
[0018] In a preferred embodiment of the present invention, in order to accurately and conveniently ob...
Embodiment 1
[0029] The vascular structure of the stent to be implanted is obtained by CT angiography, and then a three-dimensional model that fits the vascular structure is constructed in the computer according to the vascular structure of the stent to be implanted, and then the core is processed and manufactured by a 3D printer. Maltose, sucrose and fructose are mixed in a mass ratio of 1:1:1.
[0030] Mix polyvinylidene fluoride resin FR901 (purchased from Shanghai Sanaifu, with a melt mass flow rate of 16g / 10min) and dimethylformamide at a weight ratio of 1:10, stir for 4 hours and let it stand for defoaming to obtain polyvinylidene fluoride Fluorine resin solution.
[0031] Spray the obtained polyvinylidene fluoride resin solution on the surface of the core with an air pressure spray gun at 0.3 MPa air pressure and a temperature of 30°C, when the distance between the nozzle and the surface of the core is 150 mm, to form a continuous first layer of stent coating.
[0032] Set the stainl...
Embodiment 2
[0037] The vascular structure of the stent to be implanted is obtained by CT angiography, and then a three-dimensional model that fits the vascular structure is constructed in the computer according to the vascular structure of the stent to be implanted, and then the core is processed and manufactured by a 3D printer. Maltose, sucrose and glucose are mixed in a mass ratio of 1:2:5.
[0038] Mix polyvinylidene fluoride resin FR921 (purchased from Shanghai Sanaifu, melt mass flow rate 2g / 10min) and dimethylacetamide at a weight ratio of 1:80, stir for 4 hours and then let it stand for defoaming to obtain polyvinylidene fluoride Fluorine resin solution.
[0039] The obtained polyvinylidene fluoride resin solution is poured into a mold with a core, and the polyvinylidene fluoride resin solution is cast on the surface of the core to form a continuous first layer of stent coating.
[0040] The nickel-titanium alloy stent skeleton is set on the cast core with the first layer of sten...
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Abstract
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