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Large-scale production technology of liver extract

A production process, technology of liver extract, applied in the field of large-scale production of liver extract, can solve the problems of only reaching the laboratory test scale and not representing the actual level of large-scale production, and achieve good process stability, high yield and Test the effect of stable data and low price

Inactive Publication Date: 2016-04-06
GANSU PUERKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The feeding amount indicated in the disclosed examples of this patent application is only 5.0kg per batch, which only reaches the laboratory test scale and cannot represent the actual level of large-scale production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The large-scale production process steps of liver extract of the present invention are as follows:

[0062] (1) Take 500kg of frozen healthy bovine liver that removes fat, fascia and connective tissue. After thawing, grind it into mince, and use an animal cell grinder to grind and homogenize the liver cells to make liver homogenate;

[0063] (2) Put the liver homogenate prepared in step (1) into a reaction kettle, add water twice the weight of the net bovine liver, and stir evenly to make a liver homogenate suspension; separately take papain and animal proteolytic enzyme by pressing Mix at a mass ratio of 1:2 (the total amount of mixed enzymes is 0.6% of the mass of the net bovine liver), add water 3 to 4 times the mass of the net bovine liver, disperse evenly, and slowly add the above liver homogenate suspension under stirring solution, stirred at a constant temperature of 50°C, and enzymatically hydrolyzed for 6 hours;

[0064] (3) Add water twice the weight of the n...

Embodiment 2

[0067] The difference between this example and Example 1 is that the raw material used in this example is healthy sheep liver, and the rest are the same as those in Example 1.

[0068] 145.1 kg of liver extract (containing 70.8% of total solids) was obtained by applying the method of this example, which was tested to meet the requirements of the National Drug Standard WS-10001-(HD-0812)-2002 for liver extract. The yield of liver extract was 29.02%; the nitrogen content of liver extract was 14.1% (calculated by total solids), and the transfer rate of total organic nitrogen was 91.6%.

Embodiment 3

[0070] The large-scale production process steps of liver extract of the present invention are as follows:

[0071] (1) Take 1000kg of frozen healthy bovine liver that removes fat, fascia and connective tissue. After thawing, grind it into mince, and use an animal cell grinder to grind and homogenize the liver cells to make liver homogenate;

[0072] (2) Put the liver homogenate prepared in step (1) into a reaction kettle, add water 4 times the weight of the net bovine liver, and stir evenly to make a liver homogenate suspension; separately take papain and animal proteolytic enzyme by pressing Mix at a mass ratio of 0.4:1 (the total amount of mixed enzymes is 0.7% of the mass of the net bovine liver), add water 3 to 4 times the mass of the net bovine liver, disperse evenly, and slowly add the above liver homogenate suspension under stirring solution, stirred at a constant temperature of 55°C, and enzymatically hydrolyzed for 10 hours;

[0073] (3) Add water three times the wei...

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Abstract

The invention provides a large-scale production technology of a liver extract. The liver extract is obtained by mincing fresh or frozen cattle and sheep livers, breaking cell walls, and carrying out enzymolysis and water extraction with a mixed enzyme, wherein the mixed enzyme is papain and an animal protein hydrolyed enzyme. The technology can be actually utilized in large-scale production; the yield is high; the yield of the liver extract reaches 28.5%-30.0% (the total solid content is greater than or equal to 70.0%); the organic nitrogen content is greater than 13.0% on the basis of total solid content; and the transfer rate of the total organic nitrogen reaches 90% or over; and no chemical substance is added in the preparation process.

Description

technical field [0001] The invention relates to a large-scale production process of liver extract. Background technique [0002] Liver Extractum (HeparExtractum) is an extract prepared from fresh or frozen animal liver, which is an anti-anemia drug. Its preparations include liver extract tablets, compound liver extract tablets, compound liver extract capsules, compound liver extract syrup, compound embryo liver ferric ammonium tablets, etc. As an anti-anemia and nutritional supplement, it is mainly used for iron-deficiency anemia, infirmity and malnutrition after illness. [0003] The implementation standard of liver extract is the national drug standard WS-10001-(HD-0812)-2002. This product should be a brown or dark brown-red paste; it has a special fragrance and must not have a burnt smell. The total solids in the liver extract should not be less than 70% (g / g); calculated by the total solids, the nitrogen content should not be less than 8.0%, and the total sugar content...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/407A61K9/06A61P7/06A61P3/02
CPCA61K35/407A61K9/06
Inventor 金鑫罗兴平赵永亮王明明边梦瑒刘小霞
Owner GANSU PUERKANG PHARMA CO LTD
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