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Application of a Copper Adenine Coordination Polymer

A technology of coordination polymer and copper adenine, which is applied in the application field of electrochemical sensing, can solve the problem that the application of electrochemical biosensor is not reported, and achieve the effect of simple electrode modification process and dual function effect.

Active Publication Date: 2018-08-14
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for Cu 2 (N3,N9-Ade) 4 (H 2 O) 2 ·5H 2 The application of O as an electrochemical biosensor has not been reported so far

Method used

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  • Application of a Copper Adenine Coordination Polymer
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  • Application of a Copper Adenine Coordination Polymer

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Embodiment 1

[0018] The application of the copper adenine coordination polymer of the present invention in the detection of phenformin hydrochloride includes the following steps: firstly, the obtained Cu 2 (N3,N9-Ade) 4 (H 2 O) 2 ·5H 2 O and graphite powder, add liquid paraffin dropwise and grind for half an hour until it is uniform to make a carbon paste electrode. In the three-electrode system, under the differential pulse voltammetry (DPV) technology, the applied potential is 0.5V-1.2V, at 4mL 0.1molL -1 In PBS (PH=7) electrolyte, add different concentrations of c each time (the concentration of phenformin hydrochloride is 0 (that is, no test substance is added), 0.005×10-3molL-1, 0.1×10-3molL- 1, 0.15×10-3molL-1, 0.2×10-3molL-1, 0.25×10-3molL-1, 0.30×10-3molL-1, 0.35×10-3molL-1, 0.4×10-3molL-1, 0.45×10-3molL-1, 0.5×10-3molL-1, 0.55×10-3molL-1, 0.6×10-3molL-1) the analyte phenformin hydrochloride, sweep the DPV curve, and take the value on the DPV curve The peak current value Ip is obtai...

Embodiment 2

[0022] The prepared coordination polymer Cu 2 (N3,N9-Ade) 4 (H 2 O) 2 ·5H 2 O and graphite powder, add liquid paraffin dropwise and grind for half an hour until it is uniform to make a carbon paste electrode. In the three-electrode system, the cyclic voltammetry technique is used, and the applied potential is between -0.2V-0.6V and 4mL 0.1molL -1 The electrocatalytic effect of the bare electrode on hydrogen peroxide and the electrocatalytic reduction effect of hydrogen peroxide on the electrode modified with coordination polymers were detected in the electrolyte of PBS (PH=7). We found that Cu 2 (N3,N9-Ade) 4 (H 2 O) 2 ·5H 2 O can electrocatalyze the reduction process of hydrogen peroxide. Under the detection potential of -0.2V, using chronoamperometry, the coordination polymer electrode is at 0.1 mol·L -1 , PH 7.0 and deoxygenated PBS for H 2 O 2 The response time current curve of hydrogen peroxide. The figure shows that H 2 O 2 At 5.0×10 -5 mol·L -1 To 2.0×10 -3 mol·L -1 ...

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Abstract

The invention discloses a use of a copper-adenine coordination polymer in electrochemical sensing. The copper-adenine coordination polymer has a chemical formula of Cu2(N3, N9-Ade)4(H2O)2. 5H2O. An electrode is prepared from the copper-adenine coordination polymer and through a three-electrode system, phenformin hydrochloride is detected through a differential pulse voltammetry method. Through a cyclic voltammetry method and a chronoamperometry method, hydrogen peroxide is detected. The electrode modification process is simple and is free of a toxic substance CdS. The modified electrode can be used for detecting hydrogen peroxide and phenformin hydrochloride and realizes double functions of a sensor.

Description

Technical field [0001] The invention relates to the application of a copper adenine coordination polymer, in particular to the application in electrochemical sensing. Background technique [0002] Phenformin hydrochloride is a medicine used to treat adult non-insulin-dependent diabetes and some insulin-dependent diabetes. At present, the main methods used to detect phenformin include high performance liquid chromatography, spectrophotometry, chemiluminescence, and electrochemical methods. Electrochemical detection has been widely used in medical care, environmental detection, disease diagnosis and other fields due to its simple operation, high sensitivity, fast analysis speed, good selectivity, and easy portability. There is only one article on electrochemical detection (Colloids and Surfaces B: Biointerfaces 110 (2013) 8-14), which uses Graphene-CdS (minimal toxicity) and then immobilizes DNA to detect phenformin hydrochloride. [0003] Metal adenine coordination polymers are a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/48
CPCG01N27/48
Inventor 周泊项桂芹
Owner NANJING NORMAL UNIVERSITY
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