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Method for improving chitosan membrane blood compatibility through one-step coating at room temperature

A technology of blood compatibility and chitosan film, applied in the direction of coating, etc., can solve the problems of limited application range, harsh synthesis process conditions, difficult to preserve, etc., achieve broad academic value, good effect of element content and contact angle , Adhesion reduction effect

Inactive Publication Date: 2016-04-20
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the crosslinkable group of the polymer is easy to hydrolyze and crosslink during the synthesis process, which makes the conditions of the synthesis process too harsh and difficult to preserve, which limits its application range

Method used

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  • Method for improving chitosan membrane blood compatibility through one-step coating at room temperature
  • Method for improving chitosan membrane blood compatibility through one-step coating at room temperature
  • Method for improving chitosan membrane blood compatibility through one-step coating at room temperature

Examples

Experimental program
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Effect test

Embodiment 1

[0030] This embodiment includes the following steps:

[0031] Step 1. Under the condition of nitrogen protection, 16mmol of 2-methacryloyloxyethyl phosphorylcholine monomer and 4mmol of glycidyl methacrylate monomer are subjected to free radical polymerization reaction under the action of 0.1mmol initiator, free The reaction solvent of the base polymerization reaction is a mixed solvent of ethanol and tetrahydrofuran, the reaction temperature is 70°C, and the reaction time is 24h. After the reaction is completed, it is dialyzed with a dialysis bag with a molecular weight cut-off of 6000D to 8000D, and then freeze-dried at -50°C. Obtain the phosphorylcholine polymer containing epoxy group; The initiator is azobisisobutyronitrile, and the volume ratio of the ethanol and THF is 4:1;

[0032] Step 2, at room temperature (25° C.), dissolve the phosphorylcholine polymer containing epoxy groups in methanol to obtain a polymer solution with a concentration of 1 mg / mL, and then add eth...

Embodiment 2

[0048] This embodiment includes the following steps:

[0049] Step 1. Under the condition of nitrogen protection, 18mmol of 2-methacryloyloxyethyl phosphorylcholine monomer and 2mmol of glycidyl methacrylate monomer are subjected to free radical polymerization reaction under the action of 0.2mmol initiator, free The reaction solvent of the base polymerization reaction is a mixed solvent of ethanol and tetrahydrofuran, the reaction temperature is 65°C, and the reaction time is 24h. After the reaction is completed, it is dialyzed with a dialysis bag with a molecular weight cut-off of 6000D to 8000D, and then freeze-dried at -50°C. Obtain the phosphorylcholine polymer containing epoxy group; The initiator is azobisisobutyronitrile, and the volume ratio of the ethanol to THF is 5:1;

[0050] Step 2. Dissolve the phosphorylcholine polymer containing epoxy groups in methanol at room temperature (20° C.) to obtain a polymer solution with a concentration of 0.5 mg / mL, and then add Et...

Embodiment 3

[0054] This embodiment includes the following steps:

[0055] Step 1. Under the condition of nitrogen protection, 17mmol of 2-methacryloyloxyethyl phosphorylcholine monomer and 3mmol of glycidyl methacrylate monomer are subjected to free radical polymerization reaction under the action of 0.1mmol initiator, free The reaction solvent of the base polymerization reaction is a mixed solvent of ethanol and tetrahydrofuran, the reaction temperature is 75°C, and the reaction time is 20h. After the reaction is completed, it is dialyzed with a dialysis bag with a molecular weight cut-off of 6000D to 8000D, and then freeze-dried at -50°C. Obtain the phosphorylcholine polymer containing epoxy group; The initiator is azobisisobutyronitrile, and the volume ratio of the ethanol to THF is 5:1;

[0056] Step 2. Dissolve the phosphorylcholine polymer containing epoxy groups in ethanol at room temperature (30° C.) to obtain a polymer solution with a concentration of 2 mg / mL, and then add ethyl ...

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Abstract

The invention discloses a method for improving chitosan membrane blood compatibility through one-step coating at room temperature. The method includes: at the room temperature, dissolving phosphorylchloline polymer containing epoxy group in a polar solvent to obtain a polymer solution; adding ethylenediamine into the polymer solution, and mixing well to obtain a mixed solution; coating the mixed solution on the surface of a chitosan membrane, and sun-drying to obtain the chitosan membrane with an artificial cell outer layer membrane structure on the surface. The mixed solution containing the phosphorylchloline polymer and ethylenediamine is coated on the surface of the chitosan membrane at the room temperature, and the chitosan membrane with the artificial cell outer layer membrane structure can be prepared after sun-drying. The method is simple and mild in condition, and adhesion, to blood platelets, of the chitosan membrane after being improved through a one-step coating method is lowered obviously, and biocompatibility is improved remarkably.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a method for improving the hemocompatibility of chitosan membranes by further coating at room temperature. Background technique [0002] Chitosan has the advantages of degradability, antibacterial, non-toxic, non-irritating, and pH responsiveness (Carbohydrate Polymers, 2010, 79(3): 724-730), and has been widely used in biomedicine and other fields. More and more studies have shown that chitosan and its derivatives can be used for blood purification. The amino group on the chitosan molecule helps to adsorb various toxins in the blood, and can be used as a hemoperfusion material (Chemical Journal of Chinese Universities 2002, 23: 75-77; Journal of Microencapsulation 1993, 10: 475-486). Chitosan membrane has high dialysis rate, selectivity and strength, and can be used as hemodialysis material (Journal of Applied Polym...

Claims

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Application Information

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IPC IPC(8): C08J7/04C09D133/14C09D143/02C09D7/12C08F230/02C08F220/32C08L5/08
CPCC09D7/63C09D133/068C09D143/02C08F220/32C08F230/02C08J5/18C08K5/17C08J2305/08C08J2433/14C08J2443/02C08J7/0427C08F220/325
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH
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