Squalene microcapsule preparation method using ultrasonic atomizing spray drying technology

A squalene and ultrasonic technology, applied in the field of biomedicine, can solve the problems of large particle size, accumulation and deformation of core material and wall material, and achieve the effect of good fluidity and uniform particle size

Pending Publication Date: 2016-05-04
INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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Problems solved by technology

This will cause the dispersed liquid droplets to deform when they hit the wall of the flask, and they will continue to accumulate together to cause larger particle sizes, and even the core material and wall materials will accumulate during the impact process. Secondary crushing is required, resulting in different particle shapes such as needle, rhombus, triangle, and circle. The above-mentioned results lead to no effect of ultrasonic atomization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] Weigh 3g squalene and 0.8g Tween 80, add 100ml deionized water, ultrasonic emulsification, and weigh 15g of β-cyclodextrin, add to the above emulsion, continue ultrasonic emulsification to form a uniform emulsion; Ginkgo gelatinized starch , Guar gum and squalene are added to deionized water in a ratio of 1:1:5 (w:w:w), stirred and dissolved; the wall material solution and core material solution are mixed evenly in the colloid mill and then transferred to high pressure The homogenizer was sheared at high speed for a period of time to obtain a microcapsule emulsion, and the obtained microcapsule solution was subjected to ultrasonic atomization and spray drying. The obtained dried squalene microcapsule product is collected in a barrel and sealed for preservation.

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PUM

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Abstract

The present invention discloses a squalene microcapsule preparation method using ultrasonic atomizing spray drying technology. Core material is the squalene and wall materials are ginkgo biloba gelatinized starch, beta-cyclodextrin, guar gum, etc. The raw materials are mixed and homogenized and the ultrasonic atomizing spray drying technology is used to conduct microencapsulation. The microcapsules are formed by one step, the micro-particle flowability is good, the particles are circular, the particle size D70 is effectively controlled at 1-40 <mu>m, and the resulted squalene microcapsules have heat and oxidation resistance.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and belongs to the application of ultrasonic atomization and spray drying technology for preparing microcapsules in squalene and other health care products and medicines. Background technique [0002] Squalene is a kind of unsaponifiable lipid beneficial to the human body. It belongs to open-ring triterpenoid long-chain carbohydrates. Its molecular formula is C30H50 and its relative molecular weight is 410.7. Hexamethyl-2,6,10,14,18,22-tetracosahexaene. It has a variety of physiological functions and is widely used in the fields of medicine, food, cosmetics and daily necessities. [0003] Squalene was originally found in the liver oil of sharks, and it is generally believed that the liver of deep-sea sharks has the highest content. Later, it was found that it is widely distributed in plants. Although the content is not high, it is of great significance to study the extraction of squalene fr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/10A61K9/50A61K31/01A23L5/30A23P10/30
CPCA61K9/5036A61K31/01
Inventor 张彩虹黄立新谢普军丁莎莎邓叶俊张琼
Owner INST OF CHEM IND OF FOREST PROD CHINESE ACAD OF FORESTRY
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