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Macroreticular resin and preparing method thereof

A technology of pore adsorption and resin, which is applied in the field of macroporous adsorption resin and its preparation, and can solve the problems of easy generation of membranes, poor force between coating materials and adsorbents, etc.

Active Publication Date: 2016-05-11
JAFRON BIOMEDICAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This results in a relatively poor force between the coating material and the adsorbent, which tends to produce membranes

Method used

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  • Macroreticular resin and preparing method thereof
  • Macroreticular resin and preparing method thereof
  • Macroreticular resin and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Step (1): Free radical polymerization step.

[0052] Add 500mL of aqueous solution containing 0.5wt% methyl hydroxyethyl cellulose and 15wt% NaCl to a 1000mL three-necked flask, add 15g hydroxyethyl methacrylate, 60g divinylbenzene, 45g styrene, 120g toluene, 100g Mixed organic phase of methyl isobutyl ketone, 1 g of lauryl peroxide. Under mechanical stirring, raise the temperature to 55°C to react until the setting takes about 1.5 hours (hours), and continue to keep warm for 3 hours. Then raise the temperature to 80° C. and keep the temperature for curing reaction for 1 hour. Then, the temperature was raised to 90° C. and the curing reaction was carried out for 6 hours. After the reaction, wash with water until the washing solution is clear, filter with suction, dry, and then use acetone to extract methyl isobutyl ketone until it is clean. Drying, sieving, and selecting resins with particle diameters ranging from 0.55mm to 1.25mm, the macroporous resin matrix white ...

Embodiment 2

[0060] Step (1): Free radical polymerization step.

[0061] Add 500mL of aqueous solution containing 0.5wt% methyl hydroxyethyl cellulose and 15wt% NaCl to a 1000mL three-necked flask, add 15g hydroxyethyl methacrylate, 60g divinylbenzene, 45g styrene, 120g toluene, 100g Mixed organic phase of methyl isobutyl ketone, 1 g of lauryl peroxide. Under mechanical stirring, raise the temperature to 45°C to react until the setting takes about 2.5 hours (hours), and continue to keep warm for 4.5 hours. Then raise the temperature to 80° C. and keep the temperature for curing reaction for 1 hour. Then, the temperature was raised to 90° C. and the curing reaction was carried out for 6 hours. After the reaction, wash with water until the reaction solution is clear, filter with suction, dry, and then use acetone to extract methyl isobutyl ketone until it is clean. Drying, sieving, and selecting resins with particle diameters ranging from 0.50mm to 1.20mm, the macroporous resin matrix whi...

Embodiment 3

[0064] Step (1): Free radical polymerization step.

[0065] Add 500mL of aqueous solution containing 0.5wt% methyl hydroxyethyl cellulose and 15wt% NaCl to a 1000mL three-necked flask, add 15g hydroxyethyl methacrylate, 60g divinylbenzene, 45g styrene, 120g toluene, 100g Mixed organic phase of methyl isobutyl ketone, 1 g of lauryl peroxide. Under mechanical stirring, raise the temperature to 50°C to react until the setting takes about 2.0 hours, and continue to keep warm for 3.5 hours. Then raise the temperature to 80° C. and keep the temperature for curing reaction for 1 hour. Then, the temperature was raised to 90° C. and the curing reaction was carried out for 6 hours. After the reaction, wash with water until the reaction solution is clear, filter with suction, dry, and then use acetone to extract methyl isobutyl ketone until it is clean. Drying, sieving, and selecting resins with particle diameters ranging from 0.50mm to 1.20mm, the macroporous resin matrix white balls...

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Abstract

The invention relates to macroreticular resin and a preparing method thereof. The preparing method comprises the steps of a radial polymerizing step in step (1), a surface grafting step in step (2) and a postcrosslinking step in step (3) in sequence. The macroreticular resin as a blood perfusion adsorbent is used for uremia treatment, the macroreticular resin comprises matrix white balls formed by styrene class monomer, multivinyl class monomers and acrylics monomers containing hydroxyl groups, polyvinylpyrrolidone is grafted to the surface of the matrix white balls, and suspension double bonds on the matrix white balls form ultrahigh crosslinking macroreticular resin after postcrosslinking reaction. The macroreticular resin is improved in aspects of mechanical strength, adsorption performance and hemolysis effect.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to a macroporous adsorption resin used in the treatment of uremia and a preparation method thereof. Background technique [0002] In chronic renal failure, chemical substances such as creatinine, tumor necrosis factor, interleukin-6, parathyroid hormone, and β2-microglobulin have accumulated in the blood at a much higher than normal concentration due to low renal function or failure. Although dialysis artificial kidney has been successfully used clinically and prolongs the lives of many patients with renal failure, compared with normal human kidney function, dialysis can only replace part of the excretory function of the kidney, and with the increase of dialysis times , patients will rely on the hemodialyzer to detoxify, urinate, maintain acid-base and electrolyte balance, which will make the residual renal function even lower. At the same time, hemodialysis may also c...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30
CPCB01J20/264B01J20/267B01J20/28004B01J20/28019B01J20/28064B01J20/28066B01J20/28076B01J20/28083
Inventor 董凡戴宏海
Owner JAFRON BIOMEDICAL
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