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Nanogold reinforced carbon nanotube photoacoustic contrast agent and preparation method thereof

A carbon nanotube and photoacoustic contrast technology, applied in the biological field, can solve the problems of biological toxicity and low dispersion, and achieve the effects of strong targeting, good dispersion and good biocompatibility

Inactive Publication Date: 2016-05-18
XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a nano-gold-enhanced carbon nanotube photoacoustic contrast agent and its preparation method in order to overcome the shortcomings of existing carbon nanotube materials with low dispersion and certain toxicity to organisms

Method used

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  • Nanogold reinforced carbon nanotube photoacoustic contrast agent and preparation method thereof
  • Nanogold reinforced carbon nanotube photoacoustic contrast agent and preparation method thereof
  • Nanogold reinforced carbon nanotube photoacoustic contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of carbon nanotube photoacoustic contrast agent

[0025] 1. Preparation of gold nanoparticles

[0026] (1) Preparation of branched polyethyleneimine (Mn=10000), chloroauric acid solution: 1.0754g of branched polyethyleneimine (PEI) was dissolved in 100mL of deionized water, sonicated and stirred to dissolve it; 1g Chlorauric acid was dissolved in 100mL deionized water and stored in cold storage as a mother liquor for later use.

[0027] (2) Take 1 mL of the above-mentioned mother liquor of chloroauric acid, add 50 mL of deionized water to dilute, and prepare a chloroauric acid solution with a concentration of 0.2 mg / mL.

[0028] (3) get 15mL chloroauric acid solution and add dropwise in the PEI solution of (1) preparation ( Quality than PEI: HAuCl 4 ＝300:1 ), avoid light and stir for 45 minutes to make it fully mixed.

[0029](4) Preparation of nano-gold-branched polyethyleneimine solution (Au-PEI solution): the mixed solution of chloroauri...

Embodiment 2

[0044] Example 2 Preparation of carbon nanotube photoacoustic contrast agent

[0045] 1. Preparation of gold nanoparticles

[0046] (1) The specific method is the same as in Example 1.

[0047] (2) The specific method is the same as in Example 1.

[0048] (3) get 25mL of chloroauric acid and add in the prepared PEI solution ( Quality than PEI: HAuCl 4 ＝200:1 ), avoid light and stir for 45 minutes to make it fully mixed.

[0049] (4) Preparation of nano-gold solution: put the mixed solution of chloroauric acid and polyethyleneimine obtained in (3) in an oil bath at 90° C. for 1 hour. It was observed that the color of the solution was pink, and the size of the nano-gold particles was preliminarily judged. The average diameter of the obtained nano-gold particles detected by transmission electron microscopy was 25 nm, and the solution was allowed to stand at room temperature.

[0050] 2. Preparation of nano-gold-carbon nanotube composites

[0051] The specific method is ...

Embodiment 3

[0052] Example 3 Preparation of carbon nanotube photoacoustic contrast agent

[0053] 1. Preparation of gold nanoparticles

[0054] (1) The specific method is the same as in Example 1.

[0055] (2) The specific method is the same as in Example 1.

[0056] (3) get 45mL of chloroauric acid and add in the prepared PEI solution ( Quality than PEI: HAuCl 4 ＝100:1 ), avoid light and stir for 45 minutes to make it fully mixed.

[0057] (4) Preparation of nano-gold solution: put the mixed solution of chloroauric acid and polyethyleneimine obtained in (3) in an oil bath at 90° C. for 1 hour. It was observed that the color of the solution was orange-red, and the average diameter of the gold nanoparticles detected by transmission electron microscopy was 30 nm, and the solution was allowed to stand at room temperature.

[0058] 2. Preparation of nano-gold-carbon nanotube composites

[0059] The specific method is the same as that in Example 1, and finally a carbon nanotube / nano-...

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Abstract

The invention discloses a nanogold reinforced carbon nanotube photoacoustic contrast agent and a preparation method thereof. The nanogold reinforced carbon nanotube photoacoustic contrast agent prepared by the method provided by the invention is a nano-composite material, and is formed by covalent binding of carbon nanotubes (CNTs), a multi-amido compound, nanogold and thiolated polyethylene glycol (mPEG-SH). The preparation method provided by the invention adopts a two-step method to synthesize gold nanoparticles on the surfaces of the carbon nanotubes, and also has the advantages of convenient operation, green and environmental protection, etc. The nanogold reinforced carbon nanotube photoacoustic contrast agent disclosed by the invention has good dispersibility in water, strong stability and good biocompatibility, and can produce strong photoacoustic signals.

Description

technical field [0001] The invention relates to the biological field, in particular to a nano-gold-enhanced carbon nanotube photoacoustic contrast agent and a preparation method thereof. Background technique [0002] Photoacoustic imaging is a non-destructive medical imaging method developed in recent years. Due to the difference in light absorption between tumor tissue and normal tissue (under the irradiation of near-infrared laser, the light absorption difference between cancerous tissue and surrounding normal tissue is at least 5 times) and biological tissues in different physiological states have different light absorption. Acoustic imaging can reflect the structural characteristics of the tissue, and may also reflect the metabolic state of the tissue, lesion characteristics, and even neural activity. Therefore, near-infrared technology has become the research focus of current biological non-destructive testing technology. [0003] The unique molecular structure of car...

Claims

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Application Information

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IPC IPC(8): A61K49/00
Inventor 谭庆刚刘颖斌王宁程茜翁昊徐峥李茂岚李松岗束翌俊
Owner XIN HUA HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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