Method of using SMA as template to prepare chitosan nano microcapsules
A technology of chitosan nano and microcapsules, which is applied in the direction of microcapsule preparation and microsphere preparation, can solve the problems of incomplete structure and wide particle size distribution, and achieve complete shape, narrow particle size distribution and good biophase Effects of Capacitance and Degradability
Inactive Publication Date: 2016-05-25
ANHUI UNIVERSITY
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Problems solved by technology
There are many methods for the preparation of nano-microcapsules, such as self-assembly method, emulsion polymerization method, etc., but the microcapsules prepared by these methods are prone to problems such as wide particle size distribution and incomplete structure.
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Embodiment 1
[0026] The present embodiment prepares chitosan nano-microcapsules according to the following steps:
[0027] 1. Preparation of SMA template microspheres
[0028] Dissolve 1.5g of styrene and 1.41g of maleic anhydride in 30mL of ethyl butyrate, pass nitrogen gas at room temperature for 0.5h, then add 0.025g of azobisisobutyronitrile, react at 70°C for 5h, and pass nitrogen gas during the whole reaction process, After the reaction, the product was collected by centrifugation, washed twice with ethyl butyrate, and finally dried in a vacuum oven at 40°C to obtain SMA template microspheres;
[0029] figure 1 For the FT-IR spectrogram of the obtained styrene-maleic anhydride copolymer microspheres of this embodiment, from figure 1 As can be seen in the 1601cm -1 , 1495cm -1 and 1454cm -1 The absorption peak at corresponds to the stretching vibration peak of the benzene ring skeleton, 703cm -1 Corresponding to the exocyclic stretching vibration peak of the benzene ring, 1779cm...
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Abstract
The invention discloses a method of using SMA as a template to prepare chitosan nano microcapsules. The method includes: adopting a precipitation polymerization method to prepare styrene-maleic anhydride copolymer microspheres, using the microspheres prepared as the template, utilizing action between amino on chitosan and carboxyl on the template to load chitosan on the surface of the template, and using a crosslinking agent to crosslink chitosan; adopting a solvent / non-solvent inductive phase separation method as a corrosion template to obtain the chitosan nano microcapsules. The SMA which is a novel bio-compatible material is adopted as the template, interaction between the SMA and chitosan functional group is utilized to load chitosan on the surface of the template, and the chitosan nano microcapsules are obtained by removing the template. The nano microcapsules prepared are uniform in particle size and complete in shape and has biocompatibility and biodegradability.
Description
1. Technical field [0001] The invention relates to a method for preparing hollow microcapsules, in particular to a method for preparing chitosan nano-microcapsules by using SMA as a template. 2. Background technology [0002] Microcapsules refer to micro-containers with hollow structures and shells made of polymer materials or inorganic materials. Due to the characteristics of small particle size, large specific surface area, and large internal volume, microcapsules are widely used in the fields of drug delivery carriers, microreactors, sensors, catalyst carriers, sealing materials, and energy storage media. There are many methods for the preparation of nano-microcapsules, such as self-assembly method, emulsion polymerization, etc., but the microcapsules prepared by these methods are prone to problems such as wide particle size distribution and incomplete structure. The template method is an effective method for preparing nano-microcapsules, and the morphology and particle ...
Claims
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IPC IPC(8): B01J13/14C08L5/08C08L35/06C08F222/08C08F212/08
CPCB01J13/14C08F222/08C08L5/08C08L35/06C08F212/08
Inventor 聂王焰周艺峰陈鹏鹏胡振兴
Owner ANHUI UNIVERSITY