Method for producing high-purity propofol

A production method and technology of propofol, which is applied in the field of medicine, can solve the problems of high requirements for low-temperature crystallization raw materials, long operation steps, and long processing time, so as to reduce oxidation impurities J and E, improve quality and safety, and shorten the heating time The effect of shortening
CN105601477AActive Publication Date: 2016-05-25GUANGDONG JIABO PHARM CO LTD
15 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGDONG JIABO PHARM CO LTD
Publication Date
2016-05-25

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention belongs to the technical field of medicine, and particularly discloses a method for producing high-purity propofol. The method includes the steps that a propofol crude product serves as a raw material and is separated and purified with a three-stage distillation method; the propofol crude product enters a feeding tank protected by nitrogen and is input into a first-stage film distiller through a pump to be dehydrated and degassed; then the product enters a second-stage molecular distiller, and low-boiling-point impurities are removed; finally, the processed product is input into a third-stage molecular distiller through the pump, high-boiling-point impurities are separated, and the colorless or yellowish high-purity propofol is obtained. The method is simple in technology, easy to operate, convenient and rapid, oxidation can be effectively prevented, the content of toxic oxide impurities E and the content of toxic oxide impurities J are decreased, the quality and the safety of the propofol are improved accordingly, the distillation temperature is low, separating efficiency is high, energy is saved, and the method is environmentally friendly and suitable for mass production and meets the requirement of continuous integration production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of medicine, and in particular relates to a production method of high-purity propofol. Background technique

[0002] Propofol is also known as dipropofol, propofol, dipropofol, its molecular formula is: C12H180, its chemical name is: 2,6-diisopropylphenol, and its structure is shown in the following formula:

[0003]

[0004] Propofol is a rapid and short-acting intravenous anesthetic commonly used clinically for induction of anesthesia, maintenance of anesthesia, sedation of critically ill patients in the ICU, and auxiliary epidural anesthesia. It can almost fully meet the "gold standard" of intravenous anesthetics: rapid onset of action, high plasma clearance rate, rapid decrease in blood concentration, and suitable for continuous infusion administration. Quick and stable recovery after anesthesia, no mental symptoms, rarely cause postoperative nausea and vomiting, complete, less side effects and other...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More