Catalytic synthetic method of pyrrolindole compounds

Abstract

The invention relates to a catalytic synthetic method of pyrrolindole compounds represented by formula (IV) shown in the description. The method comprises the following steps: sequentially adding a compound represented by formula (I), a compound represented by formula (II), a compound represented by formula (III), a composite catalyst, gallium trichloride, an organic ligand and an organic base to an organic solvent at room temperature in nitrogen atmosphere, heating above materials to 70-85DEG C, fully stirring and reacting the materials for 4-6h, and post-processing the obtained material to obtain the compounds represented by formula (IV). The formula (I), the formula (II) and the formula (III) are shown in the description; and in the formula (I), the formula (II) and the formula (III), R1 is selected from H or a C1-C6 alkyl group, R2 is selected from H, a C1-C6 alkyl group, a C1-C6 alkyloxy group or halogen, R3 is selected from H or halogens, and X is halogen. The method adopts comprehensive selection and coordination of an appropriate reaction substrate, the catalyst, the organic ligand, the organic base and the organic solvent and use of gallium trichloride, so the target product is obtained at a high yield, and the target product has good application prospect and wide market promotion values in the field of synthesis of medicine intermediates.

Description

technical field [0001] The invention relates to a method for synthesizing condensed ring compounds, more specifically to a method for catalytically synthesizing pyrroloindole compounds, and belongs to the field of synthesizing pharmaceutical intermediates. Background technique [0002] In the fields of medicine, medical treatment, organic synthesis, etc., natural products containing indole structures occupy a very important position, because the structures containing indole often show good biological activities. Among the indole compounds, the pyrroloindole compounds are more important, which exist in a large number of alkaloids as the parent skeleton. [0003] It is precisely because of the important role of pyrroloindole compounds that the development of new synthetic techniques for pyrroloindole compounds will facilitate the synthesis of drugs and their intermediates. [0004] In recent years, a variety of synthetic methods for indole skeleton structures have been develo...

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Problems solved by technology

[0009] As mentioned above, various synthesis methods of pyrroloindole compounds have been disclosed in the prior art. However, these methods have many defects, such as a narrow range of substrates, the need for pre-functional modification of starting materials, the use of Highly toxic reagents, etc., these problems will inevitably affect the efficiency and safety of industrial scale-up production

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