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Macromolecule polymer scaffold material preparation method based on micro-fluidic technology

A technology of high molecular polymer and scaffold material, applied in the field of preparation of high molecular polymer scaffold material, can solve the problems of uneven particle size and density distribution of porogen, difficult control, limited adjustable range of pore size, etc. The method is simple, the product is uniform, and the reproducibility is good.

Inactive Publication Date: 2016-06-01
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Claims
  • Application Information

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Problems solved by technology

The porogens used in these methods have defects such as uneven particle size and density distribution, limited pore size adjustable range, and difficult control, which lead to uneven pore distribution and pore size distribution of the prepared scaffold material, which limits the ability of polymers to a certain extent. Further applications of polymer scaffold materials

Method used

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  • Macromolecule polymer scaffold material preparation method based on micro-fluidic technology
  • Macromolecule polymer scaffold material preparation method based on micro-fluidic technology
  • Macromolecule polymer scaffold material preparation method based on micro-fluidic technology

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Preparation of poly(lactic-co-glycolic acid) (PLGA) porous pellets by using liquid droplets as porogen

[0016] Prepare 2w / w% PVA aqueous solution, 1.5w / w% PLGA dichloromethane solution, and add 2w / w% surfactant Span80 in PLGA solution. The pure water is introduced into the chip from the porogen inlet, the PLGA solution is introduced into the chip from the organic phase inlet, and the PVA solution is introduced into the chip from the water phase inlet. Observe under the microscope and adjust the flow rate of each phase, so that the pure water produces droplets under the action of the PLGA solution, and the PLGA solution produces droplets under the action of the PVA solution. The PLGA solution droplets are much larger than the pure water droplets, so a large amount of Pure water droplets are wrapped in PLGA solution. In the microfluidic channel, dichloromethane is volatilized into the PVA solution, and PLGA is precipitated and solidified to form PLGA beads. Due to the o...

Embodiment 2

[0018] Preparation of Polylactic Acid (PLA) Porous Fibers Using Microspheres as Porogen

[0019] Prepare 7.5w / w% gelatin in water, 10w / w% PLA in dichloromethane, 1:1 w / w glycerin and water mixture. The gelatin aqueous solution is introduced into the chip from the porogen inlet, the PLA solution is introduced into the chip from the organic phase inlet, and the glycerin aqueous solution is introduced into the chip from the water phase inlet. Observe under the microscope and adjust the flow rate of each phase, so that the gelatin aqueous solution produces droplets under the action of the PLGA solution, and apply low-temperature stimulation to the part containing the gelatin aqueous solution droplets on the chip, so that the gelatin aqueous solution solidifies into gelatin solid particles; Under the action of glycerin aqueous solution, a laminar flow is formed, and dichloromethane volatilizes in the channel, causing PLA to precipitate and form PLA fibers. Since the PLA solution co...

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Abstract

The present invention provides a macromolecule polymer scaffold material preparation method based on a micro-fluidic technology. According to the method, a liquid droplet micro-fluidic device is used to rapidly produce a lot of uniform liquid droplets or spherical particles, and the liquid droplets or particles are adopted as the pore forming agent and are densely dispersed in an organic solvent with a dissolved macromolecule polymer so as to prepare the macromolecule polymer scaffold material with characteristics of specific morphology and uniform pore; the scaffold material prepared through the method has characteristics of uniform product, good repeatability, uniform pore distribution, uniform pore diameter, wide pore size adjustment range, controllable material shape, and the like; with the method, all preparation steps after the material feeding are completed by the one micro-fluidic device, the product collected from the micro-fluidic device terminal is the prepared final product, and the characteristics of full-automated preparation method and the like are provided; and the prepared scaffold material has the micron-scale size, is hopefully further amplified to the millimeter scale size even the centimeter scale size, and is suitable for being applied in micro-part tissue engineering.

Description

technical field [0001] The invention belongs to the intersecting field of new material technology and microfluidic technology, and specifically relates to a preparation method of a polymer scaffold material based on microfluidic technology. Background technique [0002] The core part of microfluidic technology is a microfluidic chip, also known as a chip lab, which refers to the integration of the basic operating units of a conventional laboratory on a chip of a few square centimeters (or even lower), forming a network of microchannels, The controllable flow runs through the whole system to replace various functions of conventional laboratories. In recent years, microfluidic technology has been widely used in the field of micron-scale material synthesis. The materials prepared by microfluidic technology have the characteristics of various types, various shapes, high structural complexity and good uniformity. It has become one of the important methods for the preparation of ...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/18
Inventor 秦建华于跃张晓庆
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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