Pterostilbene nano-capsules and preparation method thereof

A technology of nanocapsules and red sandalwood, which can be used in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of red sandalwood stilbene such as poor water solubility, easy degradation, and poor stability, and achieve excellent compatibility, good repeatability, and easy operation. The effect of mild conditions

Active Publication Date: 2016-06-22
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Technical problem: The object of the present invention is to: provide a kind of pterostilbene nanocapsule and its preparation method with high loading capacity, good water solubility, good stability and excellent compatibility, which solves the problem of poor water solubility of pterostilbene in the prior art, Practical application problems such as easy degradation and poor stability under high temperature operation

Method used

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  • Pterostilbene nano-capsules and preparation method thereof
  • Pterostilbene nano-capsules and preparation method thereof
  • Pterostilbene nano-capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 pterostylbene lipid nanocapsule

[0037] Composition formula

[0038]

[0039]

[0040] The preparation steps of this embodiment are as follows:

[0041] 1. Weigh 5g of caprylic capric triglyceride, 8g of polyglycerol-10-monolaurin, and 2g of polyglyceryl-6-monolaurin, put them into a 150mL beaker after weighing, and place in a 70°C water bath Stir at 300r / min until melted, as the oil phase;

[0042] 2. Weigh 54g of glycerin, 8g of sorbitol, and 20g of deionized water, put them into a 100mL conical flask with a stopper, and put them in a 70°C water bath as the water phase;

[0043] 3. Weigh 3g of rosewood stilbene into the melted oil phase, stir at 300r / min for 5min;

[0044] 4. Remove the oil phase and place it at room temperature, pour the water phase into the oil phase at one time, stir at 600r / min for 5min;

[0045] 5. Cool to room temperature to obtain pterostilbene lipid nanocapsules, and dilute it 200 times with deionized...

Embodiment 2

[0046] The preparation of embodiment 2 pterostylbene lipid nanocapsules

[0047] Composition formula

[0048]

[0049] The preparation steps of this embodiment are as follows:

[0050] 1. Weigh 10g of octyldodecanol, 5g of isohexadecane, 15g of polyglyceryl-10-monostearate, 5g of polyglyceryl-8-monostearate, weigh them and put them into a 150mL beaker. Place in a 70°C water bath and stir at 300r / min until it melts, as the oil phase;

[0051] 2. Weigh 30g of dipropylene glycol, 7g of xylitol, and 20g of deionized water, put them into a 100mL conical flask with a stopper, and place them in a water bath at 70°C as the water phase;

[0052] 3. Weigh 8g of rosewood stilbene into the melted oil phase, stir at 300r / min for 5min;

[0053] 4. Remove the oil phase and place it at room temperature, pour the water phase into the oil phase at one time, stir at 600r / min for 5min;

[0054] 5. Cool to room temperature to obtain pterostilbene lipid nanocapsules, dilute it 200 times with d...

Embodiment 3

[0055] The preparation of embodiment 3 pterostylbene lipid nanocapsule

[0056] Composition formula

[0057]

[0058] The preparation steps of this embodiment are as follows:

[0059] 1. Weigh 5g of octyldodecyl alcohol, 5g of caprylic capric triglyceride, 15g of polyglycerol-10-monolaurate, 5g of polyglycerol-10-monooleate, polyglycerol-6-monomyristic acid Put 2g of the ester into a 150mL beaker after weighing, put it in a 70°C water bath and stir at 300r / min until it melts, and use it as the oil phase;

[0060] 2. Weigh 37g of glycerin, 5g of pentaerythritol, 10g of dipropylene glycol, and 10g of deionized water. After weighing, put it into a 100mL conical flask with a stopper, and place it in a water bath at 70°C as the water phase;

[0061] 3. Weigh 8g of rosewood stilbene into the melted oil phase, stir at 300r / min for 5min;

[0062] 4. Remove the oil phase and place it at room temperature, pour the water phase into the oil phase at one time, stir at 600r / min for 5m...

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Abstract

The invention relates to pterostilbene nano-capsules and a preparation method thereof. The pterostilbene nano-capsules are prepared from, by weight, liquid oil 0.1-20%, pterostilbene active substance 0.1%-15%, an emulsifier 1%-35%, polyols 40-85% and deionized water 8-50%. The preparation method comprises the steps that (A) the liquid oil and the emulsifier are mixed together and heated for dissolution, then the pterostilbene is added, and stirring is performed till the pterostilbene is completely dissolved; (B) the polyols and the water are mixed and heated for dissolution, and even stirring is performed; (C) the solution obtained in the step (B) is added to the solution obtained in the step (A), even mixing and stirring are performed, and the solution is taken out and cooled to obtain transparent blue gel, namely the pterostilbene nano-capsules. The pterostilbene nano-capsules are simple, controllable, mild in operation, good in repeatability, high in pterostilbene load and high in stability, and the problem that the pterostilbene is insoluble in water and the content drops rapidly during high-temperature operation is solved.

Description

technical field [0001] The invention belongs to the field of carrier system preparation in cosmetics and food preparation technology. The invention relates to a method for preparing a nanoscale carrier, in particular to a method for preparing a lipid nanocapsule with pterostilbene as an active ingredient. Background technique: [0002] Pterostilbene (or pterostilbene), the chemical name is 3,5-dimethoxy-4'-hydroxystilbene; (E)-3,5-dimethoxy-4'-hydroxystyrene; ( E)-4-[2-(3,5-dimethoxyphenyl)-vinyl]-phenol; 4-[(1E)-2-(3,5-dimethoxyphenyl)-ethene Base]-phenol, which widely exists in small berries and red wine, is a structural homologue of resveratrol, and has many similar effects to resveratrol. Specific effects include: ①Excellent anti-dermatophyte effect: the antibacterial ability is 5-10 times that of resveratrol. Better reduce NFκB, iNOS and other anti-inflammatory markers; can selectively inhibit COX-2. In addition, pterostilbene has been reported to be more effective ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/14A61Q19/00A23L33/105
CPCA23V2002/00A61K8/14A61K8/347A61K2800/413A61Q19/00A23V2250/21
Inventor 夏强马超龙
Owner SOUTHEAST UNIV
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