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Preparation method of composite microgel with charged inorganic nanoparticles as cross-linking point

An inorganic nanoparticle and nanoparticle technology, applied in gel preparation, chemical instruments and methods, colloid chemistry, etc., can solve problems such as complex preparation process, and achieve the effect of simple preparation process and wide selection of materials

Active Publication Date: 2018-11-06
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the preparation of general microgels, including composite microgels, catalysts, initiators, etc. are added to chemically crosslink the polymers to form gels, and the preparation process is relatively complicated.

Method used

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  • Preparation method of composite microgel with charged inorganic nanoparticles as cross-linking point
  • Preparation method of composite microgel with charged inorganic nanoparticles as cross-linking point

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Preparation of aminated zinc oxide quantum dots

[0021] Disperse 0.816g (3.72mmol) of zinc acetate dihydrate in 20mL of absolute ethanol, reflux at 68°C for 90min.

[0022] Dissolve 0.46g (8.22mmol) of potassium hydroxide in 10mL of absolute ethanol.

[0023] Add the above-mentioned potassium hydroxide ethanol solution dropwise to the cooled zinc acetate ethanol solution, react at room temperature for 1 h, add 1 mL of 3-aminopropyltriethoxysilane, react at room temperature for 2 h, centrifuge, wash twice with ethanol, and disperse to deionized water.

Embodiment 2

[0024] Embodiment 2: Preparation of carboxymethyl dextran

[0025] Disperse 1.0 g of dextran (Mw=20 KDa) in a mixed solution of 4 mL (14.3 M) of NaOH and 22 mL of isopropanol, and stir at room temperature for 1 h. Dissolve 5.0g (3.6mmol) of bromoacetic acid in 10mL of isopropanol and slowly add it dropwise to the above reaction mixture, react at 60°C for 90min, cool to room temperature, remove isopropanol, add 20mL of methanol and stir for three minutes, The methanol was removed, and the solids in the mixture were dissolved in 20 mL of deionized water. The pH value of the solution was adjusted to between 2 and 3 with 1 M HCl, the solution was put into a dialysis bag (Mw cutoff: 50000 Da), dialyzed and freeze-dried to obtain carboxymethyl dextran.

Embodiment 3

[0026] Example 3: Preparation of composite microgels with charged nanoparticles as crosslinking points

[0027] Dissolve 20 mg of carboxymethyl dextran in 20 mL of deionized water, take 5 mL (5 mg / mL) of aminated zinc oxide quantum dot aqueous solution, add dropwise to the above dextran aqueous solution, and stir at room temperature for 10 h. Centrifuge and wash to obtain composite microgel.

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Abstract

The invention discloses a preparation method of composite microgel taking charged inorganic nanoparticles as crosslinking points.The method comprises the steps that oppositely charged inorganic nanoparticles and organic macromolecules are dissolved in deionized water or a salt solution of which the pH ranges from 6 to 12 respectively, an aqueous solution of the inorganic nanoparticles is dropwise added to an aqueous solution of the organic macromolecules, stirring is conducted, and the composite microgel is obtained.According to preparation of the composite microgel taking the charged inorganic nanoparticles as the crosslinking points, the charged inorganic nanoparticles serve as the crosslinking points to form gel with the oppositely charged macromolecules through the electrostatic interaction, a catalyst and an initiator do not need to be added, the preparation technology is simple, and the material selection range is wide.

Description

technical field [0001] The invention belongs to the field of composite microgel preparation, in particular to the preparation of composite microgel with charged nanoparticles as crosslinking points. Background technique [0002] A microgel is a highly cross-linked intramolecular polymer network that can be swelled in a solvent. Microgels can be used to load some sensitive subjects, such as drugs, proteins, nucleic acids, etc., and encapsulating them in microgels can be isolated from the outside world to avoid their inactivation. Organic-inorganic composite microgels can effectively combine the special optical, electrical, magnetic, and catalytic properties of inorganic nanoparticles with microgels to present multiple functions. For example, Richtering et al reported a magnetic nanoparticle / PNIPAm composite microgel in Journal of Colloidal and Interface Science 2008, 324(1): 47-54. Stamm et al reported a CdTe fluorescent quantum dot composite microgel in Langmuir 2008, 24(1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/00
CPCB01J13/0056B01J13/0065
Inventor 张静吴丹
Owner ZHEJIANG UNIV OF TECH
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