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Compound pharmaceutical composition for treating rhinitis in children

A composition and compound technology, applied in the field of pharmacy, can solve the problems of undiscovered pharmaceutical composition patent applications or reports, and achieve the effects of short time-consuming, low cost, and simple preparation methods

Inactive Publication Date: 2016-07-27
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching patents and related literature, no patent application or report about the pharmaceutical composition was found

Method used

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  • Compound pharmaceutical composition for treating rhinitis in children

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The prescription amount (1000 bags) and the preparation method of the compound pharmaceutical composition for rhinitis in children made into granules according to the present invention are as follows:

[0050] Element

Amount per 1000 bags (g)

Chlorpheniramine Maleate

2

3 --> Phenylephrine Hydrochloride

4

Dipotassium glycyrrhizinate

11

Hydroxypropyl-β-cyclodextrin

8

sucrose

500

Mannitol

100

Hydroxypropyl Cellulose

300

fragrance

10

purified water

Appropriate amount

[0051] Preparation Process:

[0052] (1) Weigh the raw and auxiliary materials according to the prescription amount, pass through a 100-mesh sieve for later use;

[0053] (2) Add chlorpheniramine maleate and phenylephrine hydrochloride to the hydroxypropyl-β-cyclodextrin solution, stir well and then add sucrose to make mixture 1;

[0054] (3) Take dipotassium glycyrrhizinate and mix it with t...

Embodiment 2

[0056] The prescription quantity (1000 tablets) and the preparation method of the compound pharmaceutical composition for rhinitis in children made into orally disintegrating tablets according to the present invention are as follows:

[0057] Element

Dosage per 1000 tablets (g)

Chlorpheniramine Maleate

2

Phenylephrine Hydrochloride

4

Dipotassium glycyrrhizinate

11

Polacrilin Potassium Resin (IRP88)

6

Erythritol

100

microcrystalline cellulose

50

Polyacrylic resin IV

15

Low-substituted hydroxypropyl cellulose

15

Sucralose

8

Magnesium stearate

2

fragrance

10

75% ethanol solution

Appropriate amount

purified water

Appropriate amount

[0058] Preparation Process:

[0059] (1) Weigh the raw and auxiliary materials according to the prescription quantity;

[0060] (2) Prepare 5% polyacrylic acid resin IV ethanol solution as ...

Embodiment 3

[0065] The prescription amount (1000 tablets) and the preparation method of the compound pharmaceutical composition for children's rhinitis made into oral dissolving film according to the present invention are as follows:

[0066] Element

Dosage per 1000 tablets (g)

Chlorpheniramine Maleate

2

Phenylephrine Hydrochloride

4

Dipotassium glycyrrhizinate

11

Polacrilin Potassium Resin (IRP88)

10

Methylcellulose

12

Hydroxypropyl Cellulose

4

pregelatinized starch

4

Glycerin

5

strawberry flavor

1

aspartame

2

Carmine

0.02

purified water

Appropriate amount

[0067] Preparation Process:

[0068] (1) Weigh the raw and auxiliary materials according to the prescription quantity;

[0069] (2) Dissolve chlorpheniramine maleate and phenylephrine hydrochloride in an appropriate amount of purified water, add polacrilin potassium resin and stir ev...

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PUM

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Abstract

The invention discloses a compound pharmaceutical composition for treating rhinitis in children. The active ingredients consist of chlorpheniramine maleate, phenylephrine hydrochloride and dipotassium glycyrrhizinate. The pharmaceutical composition disclosed by the invention can be made into different dosage forms according to different clinical needs, including granules, orally disintegrating tablets, orally dissolving films, oral liquid and suppositories.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a compound medicinal composition for rhinitis in children. Background technique [0002] Rhinitis is an inflammation of the nasal mucosa, with at least two of the four symptoms of runny nose, nasal congestion, sneezing, and nasal itching. Rhinitis is divided into 3 categories: allergic rhinitis (AR), infectious rhinitis and non-allergic non-infectious rhinitis. One of the most common is allergic rhinitis, also known as allergic rhinitis, its incidence rate accounts for about 30% to 40% of the whole population, and can occur at any age between 1 and 90 years old. In my country, the average incidence of allergic rhinitis is 10-15%. Experts said that the height of the average child is just at the level of the diffusion of vehicle exhaust pollutants. When walking on urban sidewalks or outdoor activities, children will inhale more vehicle exhaust, which is commonly known as "the dirtiest air", ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P11/02A61K31/4402A61K31/137
CPCA61K31/704A61K31/137A61K31/4402
Inventor 李化淋
Owner 天津市聚星康华医药科技有限公司
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