Application of ulinastatin in preparation of drugs for treating prostatic cancer

A technology for ulinastatin and prostate cancer, which is applied in the field of medicine, can solve the problems of large toxic and side effects, inhibition, urethral skin leakage, etc., and achieve the effects of low toxic and side effects, reduced expression, and prolonged medication time

Inactive Publication Date: 2016-08-03
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned various treatment methods for prostate cancer all have certain limitations. For example, the main side effects of external radiation therapy are rectal and bladder irritation symptoms; the main complication of cryotherapy is temporary urethral skin leakage; The toxic and side effects are large, which can cause myelosuppression, fatigue, nausea, vomiting, loss of appetite and other symptoms

Method used

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  • Application of ulinastatin in preparation of drugs for treating prostatic cancer
  • Application of ulinastatin in preparation of drugs for treating prostatic cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1, ulinastatin injection

[0019] Preparation method: take 100 million units of filtered sterilized ulinastatin aqueous solution, add 20 grams of mannitol to dissolve, add citric acid buffer to adjust pH to neutral, add water for injection to 1000 ml, add sodium chloride to adjust isotonicity , sterile filtered, divided into 500 vials, and obtained.

Embodiment 2

[0020] Embodiment 2, Ulinastatin injection

[0021] Preparation method: take 100 million units of filtered sterilized ulinastatin aqueous solution, add 20 grams of mannitol to dissolve, add citric acid buffer to adjust pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity , sterile filtered, divided into 1,000 vials, and obtained.

Embodiment 3

[0022] Embodiment 3, Ulinastatin injection

[0023] Preparation method: take 100 million units of filtered sterilized ulinastatin aqueous solution, add 20 grams of mannitol to dissolve, add citric acid buffer to adjust pH to neutral, add water for injection to 4000 ml, add sodium chloride to adjust isotonicity , sterile filtered, divided into 2000 vials, and obtained.

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Abstract

The invention belongs to the technical field of medicine, and specifically discloses an application of ulinastatin in the preparation of drugs for treating prostatic cancer. The test results show that ulinastatin can prominently prevent the weight loss of naked mice with prostatic cancer and inhibit the increasing of tumor volume; and moreover, ulinastatin can increase the expression of TNF-alpha of naked mice with prostatic cancer to promote apoptosis of tumor cells and reduce the expression of NF-kB to reduce the generation of related inflammation factors, and thus finally prevents prostatic cancer. Ulinastatin has the advantages of less adverse reactions, low side and toxic effect, high safety, low cost, and good curative effect on prostatic cancer.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically discloses the use of ulinastatin in preparing a medicament for treating prostate cancer. Background technique [0002] Ulinastatin is a broad-spectrum protease inhibitor, which belongs to human endogenous anti-inflammatory substances. It is mainly synthesized in the liver, metabolized by the kidneys and excreted in the urine, and the low molecular weight components formed by its decomposition also have a strong inhibitory effect on hydrolase. It has strong anti-inflammatory, immune regulation, microcirculation improvement, anti-shock, anti-ischemia and neuroprotective effects. In addition, studies have shown that ulinastatin has a protective effect on the heart, liver, kidney, lung and other important organs of the human body. Chinese patent application 201410058044.X discloses the use of artesunate and ulinastatin in the treatment of pancreatitis. It can reduce the dosage of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/57A61K9/08A61K9/19A61K47/26A61P35/00
CPCA61K38/57A61K9/0019A61K9/08A61K9/19A61K47/26
Inventor 宋建东叶晓春孙明晖侯维静赵菁
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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