A CT contrast agent based on nano pt@bsa biomimetic material and its preparation method and application

Abstract

The invention discloses a CT contrast agent based on a nano Pt@BSA biomimetic material and a preparation method and application of the CT contrast agent. The contrast agent is composed of bovine serum albumin and nano platinum particles and characterized in that the nano platinum particles are wrapped by the bovine serum albumin, and the particle diameter of the contrast agent ranges from 1 nm to 10 nm. Compared with a traditional iodine-based micromolecular contrast agent which is clinically applied, the CT contrast agent based on the nano Pt@BSA biomimetic material has the advantages that a high X-ray absorption coefficient is achieved; the nano platinum particles wrapped by the bovine serum albumin are good in stability, water solution dispersibility and biocompatibility and long in blood staying time; surface functional modification is easy to conduct; a reaction for synthesizing the biomimetic nano material with protein as a template is conducted in a water solution, the preparation method conforms to the concept of green synthesis, and environmental pollution can be reduced to a certain extent.

Description

technical field [0001] The invention belongs to the technical field of contrast agents, and in particular relates to a CT contrast agent based on a nano-Pt@BSA bionic material and its preparation method and application. Background technique [0002] Early diagnosis and treatment of malignant tumors is a research hotspot and difficulty in the field of biomedicine today. Molecular imaging integrates molecular biochemistry, data processing nanotechnology, image processing and other technologies, and uses imaging methods to conduct qualitative and quantitative research on biological processes in vivo at the cellular and molecular levels, and directly displays cells or molecules through images. Physiological and pathological processes at the same level, so as to non-invasively explore the early biological changes, metabolic level, genetic abnormalities, etc. of the disease, and then realize the early diagnosis of the disease, the screening of active drugs in vivo, and the direct,...

AI Technical Summary

Problems solved by technology

However, due to its small molecular weight, it can be rapidly metabolized in the human kidney, resulting in a relatively short blood circulation time in vivo, which greatly limits its application in specific targeted imaging techniques and angiography.

Although better and newer iodine contrast agents with low toxicity and permeability have been developed, their low X-ray absorption coefficient and inability to target modification have not been really overcome.

Other limitations include: (1) toxicity: nephrotoxicity in some cases, renal failure, anaphylactic shock; (2) high osmolarity and viscosity can also cause some adverse toxic side effects; (3) low iodine Molecular weight gives it a low X-ray absorption number, limiting the increase in its sensitivity

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