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Pharmaceutical composition containing acipimox and medical application of pharmaceutical composition

A composition and drug technology, applied in the field of pharmaceutical compositions of acyclolimus, can solve problems such as no reports on the relevance of pharmaceutical compositions, and achieve the effects of outstanding substantive characteristics, remarkable progress, and improved neuroprotective effect

Inactive Publication Date: 2016-08-03
SUZHOU BINUOJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between the pharmaceutical composition of acipimox and neuroprotection

Method used

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  • Pharmaceutical composition containing acipimox and medical application of pharmaceutical composition
  • Pharmaceutical composition containing acipimox and medical application of pharmaceutical composition
  • Pharmaceutical composition containing acipimox and medical application of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0019] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0020] Separation method: (a) crush the dried mint leaves (5kg), extract with 75% ethanol under heat reflux (20L × 3 times), combine the extracts, concentrate until no alcohol smell (4L), and then use petroleum ether (4L× 3 times), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) The ethyl acetate extract in (a) was removed with D101 type macroporous resin, first eluted with 8% ethanol for 6 column volumes, then with 70% ethanol for 8 column volumes, collected 70% eluate, and...

Embodiment 2

[0023] Example 2: Neuroprotection

[0024] 1. Materials and Instruments

[0025] The PC12 cell line was donated by the Experimental Center of Anhui University of Traditional Chinese Medicine. Aβ 1-40Protein was purchased from Sigma Company. Compound (I) is self-made, and the HPLC normalized purity is greater than 98%. DMEM / F12 medium (imported packaging was purchased from Beijing Thermo Fisher Biochemical Products Co., Ltd. NewbomCalfSerum was purchased from Beijing SolarbioScience&Technology Co., Ltd. MTT was purchased from Amresco, USA. KGI AnnexinV-FITC Cell Apoptosis Detection Kit was purchased from From Nanjing KGI Biotechnology Co., Ltd. Paraformaldehyde was purchased from China Pharmaceutical Group Chemical Reagent Co., Ltd. Bcl-2 polyclonal antibody was purchased from Wuhan Boster Biotechnology Co., Ltd. Bax polyclonal antibody was purchased from Beijing Boaosen Biotechnology Co., Ltd. Cyt-c polyclonal antibody was purchased from Wuhan Boster Biotechnology Co., Ltd...

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PUM

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Abstract

The invention discloses a pharmaceutical composition containing acipimox and medical application of the pharmaceutical composition. The pharmaceutical composition containing acipimox contains acipimox and a natural product compound (I) which is obtained through separation from dry leaves of herba menthae and is novel in structure, and when acipimox and the natural product compound (I) independently act, the neuron protection effect is weak; when acipimox and the natural product compound (I) jointly act, the neuron protection effect is significantly improved, and the pharmaceutical composition can be developed into a neuron protection drug. Compared with the prior art, the prominent substantive features and significant progress are achieved.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of acipimox, in particular to a pharmaceutical composition of acipimox and its neuroprotective medical application. Background technique [0002] Acipimox is a new lipid-lowering drug against lipidation. Its functions are as follows: ①Inhibit the release of free fatty acids from the adipose tissue of the whole body, reduce the raw materials for the synthesis of cholesterol and triglycerides, thereby reducing the contents of plasma total cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins. ②Increase the content of high-density lipoprotein in plasma, which is beneficial to the transport and removal of cholesterol. ③ Increase liver glycogen synthesis, reduce blood sugar content, and promote fatty acid decomposition to maintain blood sugar, thereby reducing cholesterol and triglyceride synthesis raw materials. ④Antioxidant effect can inh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C49/757C07C45/79A61K31/4965A61K31/122A61P25/00
CPCA61K31/122A61K31/4965A61K36/534C07C45/79C07C49/757A61K2300/00
Inventor 徐珍
Owner SUZHOU BINUOJIA PHARMA CO LTD
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